Phytotoxicity of VO nanoparticles with different sizes to pea seedlings.

Vanadium dioxide nanoparticles (VO NPs) have been massively produced due to their excellent metal-insulator transition characteristics for various applications. Pilot studies indicated the toxicity of VO NPs to bacteria and mammalian cells, but the environmental hazards of VO NPs to plants have been unrevealed to date. In this study, we reported the inhibitive effects of VO NPs to the growth and photosynthesis of pea seedlings.

Divergent Reassortment and Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Virus in Birds of China During 2021.

Highly pathogenic influenza A(H5N8) viruses had caused several outbreaks among wild bird and poultry populations across the globe, and strikingly, caused human infection, posing serious public health concerns. In this study, we conducted influenza surveillance in China during 2021 to monitor the evolution of influenza viruses in poultry. A total of 35 influenza viruses were obtained in chickens, ducks, and geese, of which 30 H5N8 viruses, 3 H5N1 viruses, and 2 H5N6 viruses.

Ferroptosis in Glioma Immune Microenvironment: Opportunity and Challenge.

Glioma is the most common intracranial malignant tumor in adults and the 5-year survival rate of glioma patients is extremely poor, even in patients who received Stupp treatment after diagnosis and this forces us to explore more efficient clinical strategies. At this time, immunotherapy shows great potential in a variety of tumor clinical treatments, however, its clinical effect in glioma is limited because of tumor immune privilege which was induced by the glioma immunosuppressive microenvironment, so remodeling the immunosuppressive microenvironment is a practical way to eliminate glioma immunotherapy resistance. Recently, increasing studies have confirmed that ferroptosis, a new form of cell death, plays an important role in tumor progression and immune microenvironment and the crosstalk between ferroptosis and tumor immune microenvironment attracts much attention.

Lymph Node Ratio Improves Prediction of Overall Survival in Esophageal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy: A National Cancer Database Analysis.

Objective: This study aimed to propose a revised ypN (r-ypN) classification based on lymph node ratio (LNR) and to examine its prognostic value in postneoadjuvant esophageal cancer.

Background: A new postneoadjuvant pathologic (ypTNM) staging classification has been introduced for esophageal cancer. However, the ypN classification currently defined by the number of positive lymph nodes is influenced by the extent of lymphadenectomy.

Phenylboronic ester-modified polymeric nanoparticles for promoting TRP2 peptide antigen delivery in cancer immunotherapy.

The tremendous development of peptide-based cancer vaccine has attracted incremental interest as a powerful approach in cancer management, prevention and treatment. As successful as tumor vaccine has been, major challenges associated with achieving efficient immune response against cancer are (1) drainage to and retention in lymph nodes; (2) uptake by dendritic cells (DCs); (3) activation of DCs. In order to overcome these barriers, here we construct PBE-modified TRP2 nanovaccine, which comprises TRP2 peptide tumor antigen and diblock copolymer PEG-b-PAsp grafted with phenylboronic ester (PBE).

The Impact of Digital Economy of Resource-Based City on Carbon Emissions Trading by Blockchain Technology.

To reduce the carbon emission intensity of resource-based cities and strengthen the sustainable development of these cities, firstly, blockchain technology is analyzed. Secondly, the development of the digital economy is discussed in digital resource-based cities. Finally, according to blockchain technology, a model of carbon emissions trading in the digital economy is designed, and the specific impact of the digital economy on carbon emissions trading is studied according to the model.

The Genomic Evolution and the Transmission Dynamics of H6N2 Avian Influenza A Viruses in Southern China.

In China, the broad prevalence of H6 subtype influenza viruses, increasingly detected in aquatic birds, promotes their exchange materials with other highly pathogenic human-infecting H5N1, H5N6, and H7N9 influenza viruses. Strikingly, some H6 subtype viruses can infect pigs, dogs, and humans, posing risks to public health. In this study, 9 H6N2 viruses recovered from waterfowl species in the Guangdong province of China in 2018 were isolated and sequenced.

A Novel Modification of Copper (II) Phthalocyanine Particles towards Electrophoretic Displays.

Electrophoretic display (EPD) is a popular display technology in recent years. The core of the EPD is electrophoretic particles, and its Zeta potential has an important impact on EPDs. In this work, a method using pyrrolidine mono ionic liquid was proposed to improve the Zeta potential of electrophoretic particles: Copper (II) phthalocyanine pigment was modified with mono ionic liquid 1-Butyl-1-methylpyrrolidinium bromide.

Application of Graphic Design with Computer Graphics and Image Processing: Taking Packaging Design of Agricultural Products as an Example.

With development of economy, all industries have undergone earthshaking changes. Various new technologies are starting to be employed in all aspects of life, and graphic design is no exception. The use of computer graphics and image processing technologies in graphic design can substantially improve design efficiency and make graphic design job more convenient to develop.

Identification and anti-tumor evaluation of 3-acyl-indol-based 2,4-diarylaminopyrimidine analogues as potent ALK inhibitors capable of overcoming drug-resistant mutants.

A series of novel 2,4-diarylaminopyrimidine analogues (G-1∼G-8 and I-1∼I-24) were rationally designed by incorporating 2-alkyl-3-acyl-1H-indol fragment to interact with the hydrophobic region of the intractable ALK mutant. Wherein, compound I-24 bearing a 2-methyl-3-dimethylformamido-1H-indol moiety was identified as the most promising ALK inhibitor with IC values below 4 nM against ALK, ALK and ALK, accompanied by concrete down-regulation of phospho-ALK and its relative downstream signaling. Subsequently, I-24 displayed significant anti-proliferative activity in the nanomolar range towards ALK-positive cell lines including a panel of Ba/F3 cells harboring mutational ALK.

A Battery Method to Enhance the Degradation of Iron Stent and Regulating the Effect on Living Cells.

Iron is a promising material for cardiovascular stent applications, however, the low biodegradation rate presents a challenge. Here, a dynamic method to improve the degradation rate of iron and simultaneously deliver electrical energy that could potentially inhibit cell proliferation on the device is reported. It is realized by pairing iron with a biocompatible hydrogel cathode in a cell culture media-based electrolyte forming an iron-air battery.

Study on the Mechanical Properties, Wear Resistance and Microstructure of Hybrid Fiber-Reinforced Mortar Containing High Volume of Industrial Solid Waste Mineral Admixture.

The use of a high volume of industrial solid waste mineral admixture and hybrid fiber can greatly reduce the amount of cement in mortar or concrete, improve its performance, ensure the service properties of mortar or concrete, and reuse industrial solid waste to reduce the environmental burden, which has significant research significance. In this paper, the mechanical properties, wear resistance and microstructure of hybrid fiber-reinforced mortar (HFRM) with a high content of industrial solid waste mineral admixture were systematically studied under different water/binder ratios. Mineral admixtures include fly ash, silica fume and granulated blast furnace slag (slag).

Non-Destruction Evaluation Method for Long-Term Oxidation Behavior of SiC/SiC Composites with Different Preforms in Wet Oxygen.

The implementation of SiC fiber reinforced SiC/SiC composites to aero-engine hot components has attracted wide attention, due to their many excellent properties. Along these lines, in order to predict the oxidation behavior of the material in extreme environments and to explore the effect of different preforms on the oxidative behavior of the composites, four SiC/SiC composites, with different preforms, were oxidized under environmental conditions of pressure of 12 kPa HO:8 kPa O:80 kPa Ar, at 1400 °C temperature. Moreover, the morphology and defect distribution of the samples were characterized by carrying out scanning electron microscopy, and micro-computed X-ray tomography measurements.

Mitochondria ROS and mitophagy in acute kidney injury.

Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged mitochondria and the production of reactive oxygen species (ROS). The relationship between mitochondria oxidative stress, ROS production and mitophagy are intimately interwoven, and these processes are all involved in various pathological conditions of acute kidney injury (AKI). The elimination of damaged mitochondria through mitophagy in mammals is a complicated process which involves several pathways.

Considerations for the Surgical Management of Thoracic Cancers During the COVID-19 Pandemic: Rational Strategies for Thoracic Surgeons.

Objective: The novel Coronavirus Disease 2019 (COVID-19) has resulted in a global health crisis since first case was identified in December 2019. As the pandemic continues to strain global public health systems, elective surgeries for thoracic cancer, such as early-stage lung cancer and esophageal cancer (EC), have been postponed due to a shortage of medical resources and the risk of nosocomial transmission. This review is aimed to discuss the influence of COVID-19 on thoracic surgical practice, prevention of nosocomial transmission during the pandemic, and propose modifications to the standard practices in the surgical management of different thoracic cancer.

Construction of A Novel Ferroptosis-related Prognostic Risk Signature for Survival Prediction in Clear Cell Renal Cell Carcinoma Patients.

Purpose: Targeted ferroptosis is a reliable therapy to inhibit tumor growth and enhance immunotherapy. This study generated a novel prognostic risk signature based on ferroptosis-related genes (FRGs), and explored the ability in clinic for clear cell renal cell carcinoma (ccRCC).

Materials And Methods: The expression profile of mRNA and FRGs for ccRCC patients were exacted from The Cancer Genome Atlas (TCGA) database.

A Novel Inflammation-Related Gene Signature for Overall Survival Prediction and Comprehensive Analysis in Pediatric Patients with Wilms Tumor.

Wilms tumor (WT) is a common pediatric renal cancer, with a poor prognosis and high-risk recurrence in some patients. The inflammatory microenvironment is gradually gaining attention in WT. In this study, novel inflammation-related signatures and prognostic model were explored and integrated using bioinformatics analysis.

Multifunctional Yolk-Shell Structured Magnetic Mesoporous Polydopamine/Carbon Microspheres for Photothermal Therapy and Heterogenous Catalysis.

Yolk-shell structure with magnetic core, interior void and mesoporous polymer/carbon shell demonstrate potential applications in biocatalysis, magnetic biological separation, biomedicine, and magnetic resonance imaging due to their comprehensive benefits of magnetic and mesoporous shells. Herein, yolk-shell structured magnetic mesoporous polydopamine microspheres (FeO@Void@mPDA) and the corresponding derivatives of carbon-based microspheres (FeO@Void@mCN) are successfully fabricated through an interface assembly and selective etching approach. The obtained monodisperse FeO@Void@mPDA microspheres consist of a magnetic core, a mesoporous polydopamine shell, and the large void formed between them, with perpendicular mesopores (5.

Establishment and Verification of Prognostic Nomograms for Young Women With Breast Cancer Bone Metastasis.

Purpose: The prognosis of patients with metastatic breast cancer usually varies greatly among individuals. At present, the application of nomogram is very popular in metastatic tumors. The present study was conducted to identify independent survival predictors and construct nomograms among young women with breast cancer bone metastasis (BCBM).

Hot Deformation Behavior of the 25CrMo4 Steel Using a Modified Arrhenius Model.

25CrMo4 steel is widely used in the manufacturing of high-speed train axles due to its excellent mechanical properties. The purpose of this study is to develop an accurate modified constitutive model to describe the hot deformation behavior of the steel. Isothermal compression experiments were performed at different strain rates (0.

Can "domino" therapy effectively treat the infection around the prosthesis after the limb salvage surgery of bone tumor? - A study of sequential therapy.

Background: Tumor resection and prosthetic replacement have become the treatments of choice for malignant bone tumors. Infections are the leading cause of failure of limb salvage surgeries. Therefore, treating infections around prostheses after limb salvage is essential and challenging.

Self-Healing Silver Nanowires and Reduced Graphene Oxide/Polyurethane Composite Film Based on the Diels-Alder Reaction under Infrared Radiation.

The hybrid composite of silver nanowires (AgNWs) and reduced graphene oxide (RGO) was synthesized in situ by an improved polyol-thermal method. The AgNWs-RGO with mass contents of 5-37 wt% was added into the thermo-reversible Diels-Alder reaction polyurethane (DA-PU) matrix with the AgNWs as the main conductor and the RGO as the auxiliary conductor to prepare self-healing composite conductive films. Further, the electrical conductivity, thermal conductivity, mechanical properties, infrared thermal response, and self-healing property of the composite film under infrared light irradiation were studied.

Better Coverage of the ACL Tibial Footprint and Less Injury to the Anterior Root of the Lateral Meniscus Using a Rounded-Rectangular Tibial Tunnel in ACL Reconstruction: A Cadaveric Study.

Background: To better restore the anatomy of the native anterior cruciate ligament (ACL) attachment and fiber arrangement, researchers have developed techniques for changing the shape of the ACL bone tunnel during ACL reconstruction.

Purpose: To compare the coverage of the ACL tibial footprint and influence on the anterior root of lateral meniscus (ARLM) between a rounded-rectangular tibial tunnel and a conventional round tibial tunnel for ACL reconstruction.

Study Design: Controlled laboratory study.