Publications by authors named "Zhang Huan"

Background: Liver graft function is related to the quality of liver transplantation (LT). High-quality perioperative glycemic management is considered hepatoprotective. However, no studies have explored the effects of specialized and staged blood glucose management target ranges on reducing glycemic variability (GV) and early allograft dysfunction (EAD) after LT.

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Global food production faces persistent threats from environmental challenges and pathogenic attacks, leading to significant yield losses. Conventional strategies to combat pathogens, such as fungicides and disease-resistant breeding, are limited by environmental contamination and emergence of pathogen resistance. Herein, we engineered sunlight-sensitive and biodegradable carbon dots (CDs) capable of generating reactive oxygen species (ROS), offering a novel and sustainable approach for plant protection.

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The CLL1-targeted chimeric antigen receptor T (CAR-T) cell therapy offers a novel therapeutic approach for refractory or relapsed acute myeloid leukemia (AML).The targeted elimination of tumor cells by CLL1 CAR-T therapy also induces cytotoxic effects on neutrophils, leading to a severe granulocytopenia, thereby significantly increasing the risk of infectious complications during CAR-T therapy. However, the infectious complications associated with this strategy have not been comprehensively investigated.

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Aim: Crizotinib, an anaplastic lymphoma kinase tyrosine kinase inhibitor (ALK-TKI). It gained approval from the U.S.

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Microseismic monitoring is crucial in realizing intelligent early warning of coal mine rockbursts. Utilizing historical microseismic monitoring data to predict future microseismic events effectively enhances the accuracy of impact disaster prediction and early warning. Due to the complexity and nonlinearity of microseismic data, conventional time series prediction models struggle to forecast them accurately.

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Intensive inflammation induced via bacterial infection seriously disturb the immune-microenvironment and compromise the neovascularization in the skin wound. On the basis of reducing bacterial infections, alleviating inflammatory response and rebuild the crosstalk between macrophages and vascular endothelial cell (VEC) serve as the key strategy for facilitating infected wound healing. Herein, manganese tetroxide (MnO) nanozymes and polydopamine-coated hydroxyapatite (PHA) nanoparticles were loaded on the gelatin methacryloyl (GelMA) hydrogel, which was subsequently crosslinked by the UV light to construct a multifunctional hydrogel wound dressing GelMA-PHA-MnO with excellent anti-bacterial, immuno-regulation and angiogenic properties.

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The target of rapamycin (TOR) kinase is an evolutionarily conserved atypical Ser/Thr protein kinase present in yeasts, plants, and mammals. In plants, TOR acts as a central signaling hub, playing a pivotal role in the precise orchestration of growth and development. Extensive studies have underscored its significant role in these processes.

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Background: This study aimed to assess the predictive value of 7 routinely available inflammation biomarkers for stroke and all-cause mortality in 229 non-valvular AF patients.

Methods And Results: C-reactive protein, Albumin (ALB), d-dimer, fibrinogen, the number of platelets, lymphocytes, monocyte and neutrophils were measured. The Multivariable Cox proportional hazard model was used to assess the predictive value of the inflammation biomarkers for stroke and all-cause mortality, the c-statistic, Net Reclassification Improvement (NRI), and Integrated Discrimination Improvement (IDI) were calculated.

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Salix variegata, a typical dioecious plant with high reproductive and adaptive ability, has important ecological and ornamental value. To understand the potential mechanisms and metabolite dynamics of male and female flowers development, the first comparative analysis of the transcriptome and metabolome of S. variegata was applied.

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Background: Frailty has been consistently implicated as a pivotal factor in the onset of delirium following anesthesia and surgery. Nonetheless, a comprehensive understanding of the relationship between frailty and delirium remains to be elucidated. This study addresses that knowledge gap.

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Phosphate-solubilizing microorganisms (PSM) play a crucial role in promoting crop growth by enhancing phosphorus supply and reducing phosphorus loss in soil. However, a comprehensive bibliometric overview of the research landscape on PSM in agricultural applications has been lacking. This study conducts a bibliometric analysis to explore global research trends, key contributors, and collaborative networks in the application of PSM in ecological restoration, providing valuable insights for future research.

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Globally, freshwater ecosystems are threatened by multiple stressors, yet our knowledge of how they interact to affect food web structure remains scant. To address this knowledge gap, we conducted a large-scale mesocosm experiment to quantify the single and combined effects of three common anthropogenic stressors: warming, increased nutrient loading, and insecticide pollution, on the network structure of shallow lake food webs. We identified both antagonistic and synergistic interactive effects depending on whether the stressors affected negative or positive feedback loops, respectively.

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Hippocampal neurogenesis, the generation of new neurons in the dentate gyrus (DG) of mammalian hippocampus, is essential for cognitive and emotional processes. Despite advances in understanding the transcription factors and signaling pathways that regulate DG neurogenesis, the epigenetic mechanisms underlying the molecular changes necessary for granule neuron generation remain poorly understood. In this study, we investigate the role of the H3K9 demethylase KDM3A in postnatal neurogenesis in mouse DG.

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Anthocyanins in tea (Camellia sinensis) leaves enhance tea quality due to their unique health benefits. MYB transcription factors are crucial in regulating anthocyanin biosynthesis in various plant species. In this research, a typical R2R3 repressive transcription factor CsMYB308 was identified which includes an EAR motif that belongs to the SG4 subfamily and was localized in the nucleus.

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Sepsis, a heterogeneous illness produced by a dysregulated host response to infection, remains a severe mortality risk. Recent discoveries in sepsis research have stressed phenotyping as a feasible strategy for tackling heterogeneity and enhancing therapy precision. Sepsis phenotyping has moved from traditional stratifications based on severity and prognosis to dynamic, phenotype-driven therapeutic options.

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In complex and diverse environments, plants face constant challenges from various pathogens, including fungi, bacteria, and viruses, which can severely impact their growth, development, and survival. Mosses, representing early divergent lineages of land plants, lack traditional vascular systems yet demonstrate remarkable adaptability across diverse habitats. While sharing the fundamental innate immune systems common to all land plants, mosses have evolved distinct chemical and physical defense mechanisms.

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N6-methyladenosine (m6A) is the most common and abundant internal co-transcriptional modification in eukaryotic RNAs. This modification is catalyzed by m6A methyltransferases, known as "writers", including and , and removed by demethylases, or "erasers", such as and . It is recognized by m6A-binding proteins, or "readers", such as , , , and .

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Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. The worldwide increase in the incidence of IBD imposes a significant economic burden on patients and communities. Recently, numerous studies have shown that disruption of the balance between the host and microbes, known as dysbiosis, is strongly associated with the development of IBD.

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Aiming at the problems of high working resistance and high energy consumption in potato crop harvesting in sticky soil, this paper designs a potato bionic drag-reducing digging shovel based on the streamline shape of catfish head. Based on the theoretical analysis and discrete element method (DEM) simulation, the main factors affecting the digging resistance are the angle of entry, forward speed and vibration frequency, and the digging resistance increases with the increase of forward speed, and decreases with the increase of vibration frequency. Through the orthogonal test in the field, the optimal working parameters of the drag reduction performance are determined with the digging resistance as the test index, and the comparative test of the different shovel shapes is carried out with this parameter.

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Multiple morphological abnormalities of sperm flagella (MMAF) is a severe form of asthenoteratozoospermia, characterized by morphological abnormalities and reduced motility of sperm, causing male infertility. Although approximately 60% of MMAF cases can be explained genetically, the etiology of the remaining cases is unclear. Here, we identified two novel compound heterozygous variants in the gene, dynein axonemal heavy chain 10 (DNAH10), in three patients from two unrelated Pakistani families using whole-exome sequencing (WES), including one compound heterozygous mutation (DNAH10: c.

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N6-methyladenosine (m6A), the most prevalent RNA modification in eukaryotes, plays a critical role in the development and progression of various diseases, including cancer, through its regulation of RNA degradation, stabilization, splicing, and cap-independent translation. Emerging evidence underscores the significant role of m6A modifications in both pro-tumorigenic and anti-tumorigenic immune responses. In this review, we provide a comprehensive overview of m6A modifications and examine the relationship between m6A regulators and cancer immune responses.

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Objective: The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases (CLM).

Methods: A total of 196 eligible patients were enrolled in the study between August 2016 and January 2023. Functional MR was performed at baseline and after one cycle of chemotherapy.

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Background: The real-world vaccine effectiveness (VE) of the diphtheria, tetanus, and acellular pertussis (DTaP), DTaP- type b (Hib), and DTaP-inactivated polio (IPV)/Hib vaccines has not been thoroughly evaluated in China. Additionally, there are limited data on the VE of acellular pertussis-containing vaccines (aPVs) when used interchangeably.

Methods: We conducted a matched case-control study to estimate the VE of aPVs against polymerase chain reaction-confirmed pertussis infection in Lu'an in 2024.

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Introduction: The Comprehensive Complication Index (CCI) is an internationally recognised indicator of postoperative complications. During the perioperative period, patients with diabetes mellitus (DM) or impaired glucose tolerance (IGT) may experience a significant increase in the CCI associated with glucose-related complications and increased mortality. Continuous glucose monitoring (CGM) offers advantages such as portability, accuracy, real-time monitoring and rich information.

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