TRPML1 agonist ML-SA5 mitigates uranium-induced nephrotoxicity via promoting lysosomal exocytosis.

Uranium (U) released from U mining and spent nuclear fuel reprocessing in the nuclear industry, nuclear accidents and military activities as a primary environmental pollutant (e.g., drinking water pollution) is a threat to human health.

Honeycomb-like biomimetic scaffold by functionalized antibacterial hydrogel and biodegradable porous Mg alloy for osteochondral regeneration.

Osteochondral repair poses a significant challenge due to its unique pathological mechanisms and complex repair processes, particularly in bacterial tissue conditions resulting from open injuries, infections, and surgical contamination. This study introduces a biomimetic honeycomb-like scaffold (Zn-AlgMA@Mg) designed for osteochondral repair. The scaffold consists of a dicalcium phosphate dihydrate (DCPD)-coated porous magnesium scaffold (DCPD Mg) embedded within a dual crosslinked sodium alginate hydrogel (Zn-AlgMA).

Numerical study on the stimulation effect of boundary sealing and hot water injection in marine challenging gas hydrate extraction.

This study proposed a novel development mode combining boundary sealing and hot water injection to address the challenges of gas leakage, limited reservoir sensible heat, boundary water intrusion, and low productivity faced by challenging hydrate extraction, and the stimulation effect was numerically investigated with Shenhu hydrates as the geological background. The results showed that lower boundary permeability facilitated pressure propagation and achieved volumetric dissociation of hydrates, whereas insufficient formation energy resulted in substantial gas retention. Hot water injection was effective for stimulation, but open boundaries could not maintain the high injection pressure, leading to massive hot water losses and gas escapes.

Identification of Biomarkers Associated with Oxidative Stress and Immune Cells in Acute Pancreatitis.

Purpose: Oxidative stress promotes disease progression by stimulating the humoral and cellular immune responses. However, the molecular mechanisms underlying oxidative stress and immune responses in acute pancreatitis (AP) have not been extensively studied.

Patients And Methods: We analyzed the GSE194331 dataset and oxidative stress-related genes (OSRGs).

"Point by point" source: The Chinese pine plantations in North China by evidence from mtDNA.

The geographical variation and domestication of tree species are an important part of the theory of forest introduction, and the tracing of the germplasm is the theoretical basis for the establishment of high-quality plantations. Chinese pine ( Carr) is an important native timber tree species widely distributed in northern China, but it is unclear exactly where germplasm of the main Chinese pine plantation populations originated. Here, using two mtDNA markers, we analyzed 796 individuals representing 35 populations (matR marker), and 873 individuals representing 38 populations (nad5-1 marker) of the major natural and artificial populations in northern China, respectively (Shanxi, Hebei and Liaoning provinces).

The complete chloroplast genomes of , , and and their phylogenetic positions.

H.H. Liu & B.

Cortical myelin and thickness mapping provide insights into whole-brain tumor burden in diffuse midline glioma.

Systemic infiltration is a hallmark of diffuse midline glioma pathogenesis, which can trigger distant disturbances in cortical structure. However, the existence and effects of these changes have been underexamined. This study aimed to investigate whole-brain cortical myelin and thickness alternations induced by diffuse midline glioma.

 (Poaceae, Bambusoideae), a new species from the southeast of Chongqing, China, and analysis of the morphological diversity in the core group of .

W. G. Zhang, S.

Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity.

Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose. However, the roles of lysosomes in U decorporation and detoxification remain to be elucidated. Mucolipin transient receptor potential channel 1 (TRPML1) is a major lysosomal Ca channel regulating lysosomal exocytosis.

(Primulaceae, Myrsinoideae), a new species from Chongqing, China.

A new species, , from Chongqing, China, is described and illustrated. It is assigned to subgen. Lysimachiasect.

Systematic review of Kaixinsan in treating depression: Efficacy and pharmacological mechanisms.

Introduction: Kaixinsan (KXS) has been in use as an effective classic formulation of traditional Chinese medicine for depression. However, its active components and action mechanism against depression remain elusive. The purpose of this study was to summarize and evaluate the efficacy and potential pharmacological mechanisms of KXS in antidepressant treatment.

Preparation of Copper Ion Adsorbed Modified Montmorillonite/Cellulose Acetate Porous Composite Fiber Membrane by Centrifugal Spinning.

The natural adsorption material montmorillonite (MMT) was selected, and cellulose acetate (CA) was used as the loading substrate to design and prepare a kind of green and environment-friendly recyclable porous composite fiber membrane with good heavy metal ion adsorption performance. Acetic acid modified montmorillonite (HCl-MMT), sodium dodecyl sulfonate modified montmorillonite (SDS-MMT), and chitosan modified montmorillonite (CTS-MMT) were prepared by inorganic modification and organic modification, and the porous MMT/CA composite fiber membrane was constructed by centrifugal spinning equipment. The morphological and structural changes of MMT before and after modification and their effects on porous composite fiber membranes were investigated.

A Cu-functionalized MOF and multi-walled carbon nanotube composite modified electrode for the simultaneous determination of hydroquinone and catechol.

Designing MOF-based materials with desired electrochemical activity and high electron conductivity may yield a novel electrochemical sensor that effectively detects various organic pollutants and conducts health monitoring. This study developed a facile and versatile electrochemical sensor for simultaneously monitoring the environmental pollutants hydroquinone (HQ) and catechol (CT). The electrodes are fabricated by modifying a GCE with a Cu-functionalized MOF (UiO-bpydc-Cu) and multi-walled carbon nanotubes (MWCNTs).

Two cationic iron-based crystalline porous materials for encapsulation and sustained release of 5-fluorouracil.

Iron-based crystalline porous materials (CPMs) emerged as a new class of biodegradable and non-toxic materials of high interest for drug delivery systems (DDSs) due to their high loading capacity and controllable structures. This work constructed two kinds of Fe-CPM coordination polymers (CPM-83 and CPM-85) from typical oxo-centered trimers of the iron octahedra cluster [FeO(RCOO)(TPT)] with two functional modules. The tri-topic pyridine ligand (TPT) occupied the open metal sites of the trinuclear cluster, precluding the attachment of neutralizing anions, leading to three-dimensional frameworks with a positive charge and higher stability.

A Fully Deep Learning Paradigm for Pneumoconiosis Staging on Chest Radiographs.

Pneumoconiosis staging has been a very challenging task, both for certified radiologists and computer-aided detection algorithms. Although deep learning has shown proven advantages in the detection of pneumoconiosis, it remains challenging in pneumoconiosis staging due to the stage ambiguity of pneumoconiosis and noisy samples caused by misdiagnosis when they are used in training deep learning models. In this article, we propose a fully deep learning pneumoconiosis staging paradigm that comprises a segmentation procedure and a staging procedure.

Analysis on Acupoint Selection and Combination for Amyotrophic Lateral Sclerosis Treated with Acupuncture Based on Data Mining.

Objective: The aim of the study was to explore the regularity of acupoints in the treatment of amyotrophic lateral sclerosis (ALS) by means of data mining technology.

Methods: Nine databases, including SinoMed, Chongqing VIP (CQVIP), China National Knowledge Infrastructure (CNKI), Wanfang Data, Cochrane Library, PubMed, MEDLINE, Web of Science, and Embase, were comprehensively searched till December 2021. The published clinical literature testing acupuncture in the treatment of ALS was eligible for inclusion.

Depletion of microRNA-92a Enhances the Role of Sevoflurane Treatment in Reducing Myocardial Ischemia-Reperfusion Injury by Upregulating KLF4.

Objective: As some articles have highlighted the role of microRNA-92a (miR-92a) in myocardial ischemia-reperfusion injury (MI/RI), this article aimed to investigate the effect of miR-92a on Sevoflurane (Sevo)-treated MI/RI via regulation of Krüppel-like factor 4 (KLF4).

Methods: An MI/RI rat model was established by ligating the left anterior descending coronary artery. The cardiac function, pathological changes of myocardial tissues, inflammatory response, oxidative stress and cardiomyocyte apoptosis in MI/RI rats were determined.

Development of Janus Cellulose Acetate Fiber (CA) Membranes for Highly Efficient Oil-Water Separation.

A new type of Janus cellulose acetate (CA) fiber membrane was used to separate oil-water emulsions, which was prepared with plasma gas phase grafting by polymerizing octamethylcyclotetrasiloxane (D4) onto a CA fiber membrane prepared by centrifugal spinning. The Janus-CA fiber membrane was described in terms of chemical structure using Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) analysis, energy dispersive X-ray spectroscopy (EDX) analysis and morphology by field emission scanning electron microscopy (FESEM). In this contribution, we examine the influence of spinning solution concentration, spinning speed and nozzle aperture on the centrifugal spinning process and the fiber morphology.

Dual functions of pH-sensitive cation Zr-MOF for 5-Fu: large drug-loading capacity and high-sensitivity fluorescence detection.

Nanomaterials, as carriers of small molecular drugs, have been a focal point in recent years. In this work, a carbazolyl functionalized metal-organic framework, UiO-67-CDC, was successfully synthesized employing the ligand 9H-carbazole-2,7-dicarboxylic acid (9H-2,7-CDC). Postsynthetic approaches targeted the cationization and replacement of the Lewis base carbazole site with two methyl groups, resulting in the positively charged skeleton, which has proven to be a promising carrier for the anticancer drug 5-fluorouracil (5-Fu).

Negative life events and self-harm among the elderly: Result from a survey of 7070 people aged≥60 in China.

Purposes: Negative life events have been reported as a risk factor for elderly self-harm. The aim of this study was to examine the relationship between negative life events and self-harm in a large sample of people aged 60 and older, and explore the role of some previously identified influential factors in this relationship.

Methods: Multi-stage stratified sampling method was used to select the elderly people over 60 years old in Shandong, China.

Three cases report of idiopathic angiosarcoma of the head and neck and literature review.

Herein, we reported 3 cases of angiosarcoma (AS) of the head and neck in old patients, and the etiology, pathogenesis, histopathology, immunohistochemistry, diagnosis, differential diagnosis and prognosis were discussion. Case 1, a male patient aged 86 years old was admitted due to purplish erythema on the head and face and progressive purplish edema in the orbit of the eye for 3 years. He was misdiagnosed with connective tissue disease in another hospital, and a second biopsy and histopathological examination confirmed the AS of the head and neck.

Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice.

Fucoxanthin, a potent carotenoid present in various natural sources especially from seaweeds; it exhibits several biological effects like anti-neoplastic, anti-mutagenic, anti-diabetic, anti-obesity and anti-inflammatory actions. Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here. Oral administration of fucoxanthin with and without B(a)P were studied, the results from our study shows that fucoxanthin significantly decreased tumor progression in mice exposed to B(a)P, the obtained data were correlated with increased antioxidant, apoptosis and decreased tumour marker and anti-apoptotic molecules.

Theoretical studies on the bond strength and electron density characteristics in multiple hydrogen bonded arrays.

Multipoint hydrogen bonded motifs with intermolecular N-H⋯N hydrogen bonds have been theoretically studied at the PBE0-D3/ma-def2-TZVP level. The properties of electron density at the bond critical points of hydrogen bonds have been analyzed through "atoms in molecule" (AIM) theory and "electron localization function" (ELF) method. The results imply that the secondary electrostatic interactions have a significant effect to the strength of multipoint hydrogen bonds.

Serum 14-3-3η Could Improve the Diagnostic Rate of Rheumatoid Arthritis and Correlates to Disease Activity.

Objectives: Serum 14-3-3η is a novel joint-derived proinflammatory mediator associated with rheumatoid arthritis (RA). This study aimed to evaluate the diagnostic capacity of serum 14-3-3η and its correlation with clinical variables in patients with RA.

Methods: A total of 94 patients with RA and 80 age- and sex-matched controls, including 40 healthy subjects, were included.