Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?

A-kinase anchoring protein 79/150 (AKAP79/150) is a crucial scaffolding protein that positions various proteins at specific synaptic sites to modulate excitatory synaptic intensity. As our understanding of AKAP79/150's biology deepens, along with its significant role in the pathophysiology of various human disorders, there is growing evidence that reveals new opportunities for therapeutic interventions. In this review, we examine the fundamental structure and primary functions of AKAP79/150, emphasizing its pathophysiological mechanisms in different nervous system disorders, particularly inflammatory pain, epilepsy, depression, and Alzheimer's disease.

Circular RNA NINL accelerates the malignant progression of cervical cancer.

Objective: The study's aim was to explore a novel miRNA/mRNA network mediated by circNINL in cervical cancer (CC).

Methods: Tumor tissue specimens and normal tissue specimens of 86 CC patients were collected. CircNINL, miR-2467-3p, and specificity protein 1 (SP1) expression levels in tissues were detected.

An angle-selective photonic crystal for multi-physical sensing applications.

This study reports a high-transmission photonic crystal (PC) that was optimized for TM waves at a frequency of 43.8 GHz and engineered using photonic band gap (PBG) principles to achieve angle selection. The structure demonstrated a remarkable transmission from -68° to 0°, consistently exceeding 80% efficiency.

[Retracted] Inhibition of 5‑lipoxygenase triggers apoptosis in pancreatic cancer cells.

Following the publication of the above paper, a concerned reader drew to the Editor's attention that Fig. 3 on p. 664, showing TUNEL assay data relating to apoptosis of the cell line under investigation in this paper, contained apparent anomalies, including repeated patternings of certain cells both within and between the data panels, such that it would have been difficult to have attributed these anomalies to coincidence.

A layered Janus metastructure for multi-physical quantity detection based on the second harmonic wave.

In the field of nonlinear optics and physical quantity detection, the use of the second harmonic wave (SHW) generated in ferroelectric crystals is proposed to realize multi-physical quantity detection with the Janus property. In view of the single physical quantity detected by the current research and the single application scenario, this paper proposes a multi-functional and novel nonlinear Janus metastructure (NJMS), which exploits the SHW to achieve highly sensitive multi-physical quantity detection in the terahertz frequency range and shows Janus properties in both the forward and backward directions of the system. The NJMS is realized to detect refractive indices, thicknesses, and angles with different modes in the forward and backward directions.

Second harmonic generation based on graphene hyperstructure for higher resolution and performance on top of achieving fundamental wave detection in theory.

In this paper, an innovative one-dimensional graphene hyperstructure (GHS) is proposed, allowing for the concurrent detection of multiple physical parameters in both the fundamental and second harmonic generation. The sensing characteristics of GHS pertaining to magnetic field strength (B), incident electromagnetic wave angle (θ), and graphene thickness (d) are systematically investigated. Moreover, through the incorporation of second harmonic generation alongside fundamental detection, higher resolution and performance are achieved.

Dual-channel asymmetric absorption-transmission properties based on plasma metastructures-photonic crystals.

In this paper, a kind of plasma metastructures-photonic crystals (PMPC) structure is proposed to investigate the absorption and transmission properties of electromagnetic waves (EWs) incident from opposite directions. The results show that the PMPC can achieve a dual-channel asymmetric absorption-transmission (AAT) phenomenon. At an operating bandwidth (OB) of 2.

Two-Periodic MoS-Type Metal-Organic Frameworks with Intrinsic Intralayer Porosity for High-Capacity Water Sorption.

2D metal-organic frameworks (2D-MOFs) are an important class of functional porous materials. However, the low porosity and surface area of 2D-MOFs have greatly limited their functionalities and applications. Herein, the rational synthesis of a class of mos-MOFs with molybdenum disulfide (mos) net based on the assembly of trinuclear metal clusters and 3-connected tripodal organic ligands is reported.

Absorptive frequency-selective transmission/reflection metamaterials with angular-insensitive and switchable octave absorption.

Absorptive frequency-selective transmission/reflection (AFST/AFSR) metamaterials (MMs) embedded with yttrium-iron-garnet are proposed, capable of achieving angular-insensitive and switchable octave absorption. The season optimization algorithm is utilized to optimize the structural parameters of the MM, thus achieving exceptional angular stability. By adjusting the discrete decreasing magnetic field applied to the MM, it can freely switch between double, triple, quadruple, and fivefold octave absorptions.

Physics-informed line graph neural network for power flow calculation.

Power flow calculation plays a significant role in the operation and planning of modern power systems. Traditional numerical calculation methods have good interpretability but high time complexity. They are unable to cope with increasing amounts of data in power systems; therefore, many machine learning based methods have been proposed for more efficient power flow calculation.

Variability in Lipid Profiles During Young Adulthood and the Risk of Coronary Artery Calcium Incidence in Midlife: Insights From the CARDIA Study.

Background: Intraindividual variability in lipid profiles is recognized as a potential predictor of cardiovascular events. However, the influence of early adulthood lipid profile variability along with mean lipid levels on future coronary artery calcium (CAC) incidence remains unclear.

Methods: A total of 2395 participants (41.

A layered metastructure for privacy protection based on the Brewster angle.

In this paper, a kind of layered metastructure (LMS) is proposed by stacking multi-layer dielectric plates. By adjusting the dielectric constant of medium A (set as ), the Brewster angle (BA) of incident electromagnetic waves (EMWs) has been directly selected. At the same time, the operating band of the above angle selection (AS) can be extended to the whole visible light band (VLB) which covers 400 nm to 700 nm according to Bragg reflection.

FTMT-dependent mitophagy is crucial for ferroptosis resistance in cardiac fibroblast.

Metabolic responses to cellular stress are pivotal in cell ferroptosis, with mitophagy serving as a crucial mechanism in both metabolic processes and ferroptosis. This study aims to elucidate the effects of high glucose on cardiomyocytes (CMs) and cardiac fibroblasts (CFs) regarding ferroptosis and to uncover the underlying mechanisms involved. We examined alterations in glycolysis, mitochondrial oxidative phosphorylation (OXPHOS), and mitophagy, which are essential for metabolic adaptations and ferroptosis.

Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study.

Objective: The impact of comprehensive risk factor control on heart failure (HF) risk and HF-free survival time in individuals with type 2 diabetes (T2D) was evaluated in this study.

Research Design And Methods: This prospective study included 11,949 individuals diagnosed with T2D, matched with 47,796 non-T2D control study participants from the UK Biobank cohort. The degree of comprehensive risk factor control was assessed on the basis of the major cardiovascular risk factors, including blood pressure, BMI, LDL cholesterol, hemoglobin A1c, renal function, smoking, diet, and physical activity.

Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia.

Introduction: Preeclampsia is a pregnancy-specific disorder characterized by de novo development of hypertension and proteinuria over 20 weeks gestation that has been associated with the dysfunction of trophoblasts. Current evidence suggests that syncytin-1 plays an important role in the non-fusogenic biological activity of trophoblasts, except for specific fusogenic function. However, the underlying mechanism remains unclear.

Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis.

Purpose: Effective therapies for metastatic osteosarcoma (OS) remain a critical unmet need. Targeting mRNA translation in metastatic OS offers a promising option, as selective translation drives the synthesis of cytoprotective proteins under harsh microenvironmental conditions to facilitate metastatic competence.

Experimental Design: We assessed the expression levels of eukaryotic translation factors in OS, revealing the high expression of the eukaryotic initiation factor 4A1 (EIF4A1).

Life's Essential 8, Genetic Susceptibility, and Incident Cardiac Arrhythmias: A Population-Based Prospective Cohort Study.

Background: Ideal cardiovascular health (CVH) has been associated with reduced cardiovascular disease risk and mortality, but its association with cardiac arrhythmias was still unsettled. In this prospective cohort study, we investigated the relationship between CVH and subsequent arrhythmias risk, including atrial fibrillation (AF)/flutter, ventricular arrhythmias, and bradyarrhythmias.

Methods: Data from 287,264 participants initially free of arrhythmias in the UK Biobank were included in the analysis.

Effectiveness and safety of brucea javanica oil assisted TACE TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials.

The effectiveness and safety of using Brucea javanica oil (BJO) in combination with Transarterial Chemoembolization (TACE) for liver cancer treatment are subjects of debate. This study aims to assess the comparative effectiveness and safety of BJO-assisted TACE TACE alone and quantifies the differences between these two treatment methods. A systematic search was conducted in multiple databases including PubMed, Cochrane, CNKI, and Wanfang, until 1 July 2023.

Sleep Patterns and Traditional Cardiovascular Health Metrics: Joint Impact on Major Adverse Cardiovascular Events in a Prospective Cohort Study.

Background: This study examines the association between traditional cardiovascular health (CVH) metrics and major adverse cardiovascular events (MACE) incidence in individuals with diverse sleep patterns.

Methods And Results: We analyzed data from 208 621 participants initially free of cardiovascular disease (CVD) in the UK Biobank study. Sleep patterns were assessed using scores for chronotype, duration, insomnia, snoring, and daytime dozing.

Dietary vitamin C and vitamin E with the risk of aortic aneurysm and dissection: A prospective population-based cohort study.

Background And Aims: The associations between dietary vitamin C (VC), vitamin E (VE) intake and aortic aneurysm and dissection (AAD) remain unclear. This study aimed to prospectively investigate the associations between dietary VC and VE with the incident risk of AAD.

Methods And Results: A total of 139 477 participants of UK Biobank cohort were included in the analysis.

SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells.

The precise mechanisms underlying the inhibitory effects of SIRT3, a mitochondrial sirtuin protein, on hepatocellular carcinoma (HCC) development, as well as its impact on mitochondrial respiration, remain poorly understood. We assessed sirtuins 3 (SIRT3) levels in HCC tissues and Huh7 cells cultured under hypoxic condition. We investigated the effects of SIRT3 on cell proliferation, glycolytic metabolism, mitochondrial respiration, mitophagy, and mitochondrial biogenesis in Huh7 cells.

An optimized metastructure switchable between ultra-wideband angle-insensitive absorption and transmissive polarization conversion: a theoretical study.

An optimized metastructure (MS) switchable between ultra-wideband (UWB) angle-insensitive absorption, and transmissive linear-to-circular (LTC) polarization conversion (PC), is proposed, which is a theoretical study. The structural parameters of this MS are optimized by the thermal exchange optimization algorithm. By modulating the chemical potential () of the graphene-based hyperbolic metamaterial embedded in the MS, the MS can achieve UWB absorption in the absorption state and LTC PC in the transmission state.