X-ray ghost imaging with a specially developed beam splitter.

X-ray ghost imaging with a crystal beam splitter has advantages in highly efficient imaging due to the simultaneous acquisition of signals from both the object beam and reference beam. However, beam splitting with a large field of view, uniform distribution and high correlation has been a great challenge up to now. Therefore, a dedicated beam splitter has been developed by optimizing the optical layout of a synchrotron radiation beamline and the fabrication process of a Laue crystal.

Modulation of oxidized low-density lipoprotein-affected macrophage efferocytosis by mitochondrial calcium uniporter in a murine model.

Objective: Efferocytosis dysfunction contributes to the progression and rupture of atherosclerotic plaques. Efferocytosis is crucially modulated by intracytoplasmic Ca, and mitochondrial calcium uniporter (MCU) complex proteins serve as key channels for regulating Ca concentration. Therefore, it was speculated that MCU may affect the development of atherosclerosis (AS) by regulating efferocytosis.

Lycopodium Alkaloids from Huperzia serrata and Their Anti-acetylcholinesterase Activities.

One new fawcettimine-type alkaloid (1), one new miscellaneous-type alkaloid (2), four new lycodine-type alkaloids (3-6), and eight known ones (7-14) were isolated from the whole plants of Huperzia serrata. Their structures and absolute configurations were elucidated based on spectroscopic data, X-ray diffraction, ECD calculation and Mosher's method. Compound 1 was a rare C N -type Lycopodium alkaloid, possessing serratinine skeleton with an amide side chain in C-5.

Excessive Treadmill Training Produces different Cardiac-related MicroRNA Profiles in the Left and Right Ventricles in Mice.

High-volume training followed by inadequate recovery may cause overtraining. This process may undermine the protective effect of regular exercise on the cardiovascular system and may increase the risk of pathological cardiac remodelling. We evaluated whether chronic overtraining changes cardiac-related microRNA profiles in the left and right ventricles.

Lipopolysaccharide Alters the m6A Epitranscriptomic Tagging of RNAs in Cardiac Tissue.

N6-methyladenosine (mA) modification plays important roles in the pathology of a variety of diseases. However, the roles of mA modification in sepsis-induced myocardial dysfunction are not well defined. Rats were divided into control and lipopolysaccharide (LPS)-induced sepsis group.

Construction and immune efficacy of recombinant Lactobacillus casei strains expressing Malt from Aeromonas veronii.

Aeromonas veronii is an important zoonotic pathogen that causes significant economic losses in the aquaculture industry. The use of probiotics in aquaculture is a practical alternative to antibiotics to promote animal health and aid in disease prevention. In the present study, we aimed to construct a recombinant Lactobacillus casei(surface-displayed or secretory) strain containing Malt from A.

Functional analysis of hisJ in Aeromonas veronii reveals a key role in virulence.

Aeromonas veronii is an important aquatic zoonotic pathogen in humans and animals. In recent years, extracellular proteins from bacteria have been found to be the major pathogenic factors for aquatic animals. The aim of this study was to systematically analyze the extracellular proteins of nine sources of A.

Primary malignant gastrointestinal neuroectodermal tumor occurring in the ileum with intra-abdominal granulomatous nodules: A case report and review of the literature.

Malignant gastrointestinal neuroectodermal tumors (GNETs) are rare aggressive malignant neoplasms that exclusively occur within the wall of the gastrointestinal tract. The GNET was first described as an 'osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma (CCS) of soft parts' in 2003. Although the GNET shares certain histological features with CCS, it is characterized by a lack of melanocytic differentiation and the presence of non-tumoral osteoclast-like giant cells (OLGCs).

The distribution of large floating seagrass (Zostera marina) aggregations in northern temperate zones of Bohai Bay in the Bohai Sea, China.

Seagrass meadows (Zostera marina) are important coastal ecosystems with high levels of productivity and biodiversity. They often have high biomass turnover and are susceptible to dislodgment, leading to export of biomass from seagrass beds. In September 2016, two cruises covering a total area of 52 km x 15 km (38°57'1.

Immunogenicity of extracellular products from an inactivated vaccine against Aeromonas veronii TH0426 in koi, Cyprinus carpio.

Aeromonas veronii is a type of human-livestock-aquatic animal pathogen; it is widely found in nature and causes many deaths among aquatic animals. Extracellular products (ECPs) are secreted by the pathogen during growth and reproduction. These products are considered effective protective antigens that can induce the host to produce an immune response.

Overexpression of MCM6 predicts poor survival in patients with glioma.

Minichromosome maintenance proteins (MCMs) play an essential role in DNA replication and other cellular activities. However, their expression levels and clinical value in glioma are unclear. In the present study, we analyzed the relationship between MCM mRNA expression and clinical parameters in 325 gliomas and found that MCM6 presented high expression and was associated with poor survival.

Phosphorylated Hsp27 is mutually exclusive with ATRX loss and the IDH1 mutation and may predict better prognosis among glioblastomas without the IDH1 mutation and ATRX loss.

Aim: To identify biomarkers for accurate classification of glioma.

Patients And Methods: We evaluated the heat shock protein 27 (Hsp27), phosphorylated Hsp27 (p-Hsp27), ATRX and IDH1proteins using immunohistochemistry in 421 glioma tissues. The χ test was used to assess the relationship between molecular alterations and clinico-pathological parameters.

Interferon alpha antagonizes the anti-hepatoma activity of the oncolytic virus M1 by stimulating anti-viral immunity.

Alpha virus M1 is an oncolytic virus that targets zinc-finger antiviral protein (ZAP)-defective cancer cells, and may be useful for treatment of hepatocellular carcinoma (HCC). Most of HCC patients have hepatitis and need long-term antiviral medication. Thus, it is necessary to clarify whether anti-virus medicines influence oncolytic effect of M1.

Comparison of pharmacokinetic profiles of Terminalia phenolics after intragastric administration of the aqueous extracts of the fruit of Terminalia chebula and a Mongolian compound medicine-Gurigumu-7.

Ethnopharmacological Relevance: The dried fruit of Terminalia chebula (fructus chebulae) is an important Traditional Medicine used for intestinal and hepatic detoxification. Gurigumu-7 which is made of fructus chebulae and 6 other traditional medicines is one of the most frequently used compound Mongolian and Tibet medicines for liver diseases. Terminalia phenolics are considered as the bioactive constituents of fructus chebulae and consequently of Gurigumu-7.

A retrospective comparison of the modified tension band technique and the parallel titanium cannulated lag screw technique in transverse patella fracture.

Objective: To compare efficacy between the modified tension band technique and the parallel titanium cannulated lag screw technique for the transverse patella fracture.

Methods: Seventy-two patients were retrospectively analyzed aged 22 to 79 years (mean, 55.6 years) with transverse patella fractures, among whom 37 patients underwent the modified tension band and 35 patients received the titanium cannulated lag screw.

[Textual research on the Wu zhi fang (Prescriptions of Five Hemorrhoids) of Ding Zhai, a lay Buddhist].

The book Wu zhi fang (Prescriptions of Five Hemorrhoids), included in the Bibliography of the Song Annals was claimed by later scholars as a book written by Dingzhai, the lay Buddhist. Parts of its contents are cited in Wei Xian's Wei shi jia cang fang (Collections of Prescriptions of the Wei Family). By the preface of the latter book, the prescriptions of the Wu zhi fang were derived from Li Yong-he, whose son passed these prescriptions to Ma Xing-si, who, in turn, gave them to Wei Xian's father Wei Xiong-meng.

Role of neuronal nitric oxide synthase in the cardiac ischemia reperfusion in mice.

Several studies have demonstrated the role of endothelial and inducible nitric oxide synthase in cardiac ischemia reperfusion(IR). However, the role of neuronal nitric oxide synthase (nNOS) in IR is still controversial. The present study was designed to explore the possible involvement of nNOS in cardiac IR.

[Approaches to acquire medical prescriptions by the Song intellectuals].

In order to treat disease of oneself or other people, the Song intellectuals were eager to collect medical recipes or compiled medical formularies. Their main approaches in this regard included conversation with medical practitioners, mutual communication among themselves, and reading medical texts. Since the effectiveness of the recipes was emphasized through the first two approaches, the approach of reading medical texts appeared to be insignificant.

[The tension between history and medicine in TCM historiography].

Before subject classification was introduced from the western world Traditional Chinese Medicine (TCM) had the background of Chinese traditional culture, and therefore the features of both medicine and historiography. After the introduction of subject classification, TCM was classified into medicine which is a science category and TCM history was classified into the historiography category. From then on, in the context of subject classification, the nature of TCM became more and more medical while less and less historic.

Effect of hyperbaric oxygen preconditioning on spleen lymphocytes and cell adhesion molecules after skin transplantation in mice.

The aim of this study was to explore the effect of hyperbaric oxygen (HBO) preconditioning on the rejection of skin allograft in mice and its molecular mechanism. BALB/c donor mice and C57BL/6 recipients received hyperbaric oxygen preconditioning once a day for 7 days. After skin transplantation, the recipients were treated with cyclosporine A (CsA) intraperitoneally.

[On relativity of the cognition of health].

The people's cognition of health has changed, from less to more. WHO (World Health Organization) put forward the definition of health, and revise it constantly. Although the people's cognition of health is developed continually, the cognition still has its own relativity, because of the difference of cognition methods, the changes of the frame of reference and uncertainty of the standard of judgment.

[The reasons of over-interpretation during the research of TCM academic history.].

Over-interpretation refers to the excessive understanding, translation and explanation of the implications which the research object represents. TCM academic history is a branch of medicine historiography to study the TCM academic development and evolution. Uncertainty of historical materials, incomplete expression of the author's original meaning and deviation of the scholars' interpretation often lead to over-interpretation during the research of TCM academic history.