Publications by authors named "Zhang Furen"
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy and the most common form of non-Hodgkin lymphoma (NHL) that occurs worldwide. To discover risk factors and pathogenesis of DLBCL, we performed the largest GWAS of DLBCL to date in samples of East Asian ancestry, consisting of 2,888 patients with DLBCL and 12,458 controls. The meta-analysis identified three novel loci, rs2233434 on 6p21.
View Article and Find Full Text PDFBackground: Severe cutaneous adverse reactions (SCARs) mediated by cytotoxic T lymphocytes are a series of life-threatening conditions with a mortality of 4%-20%. The clinical application of tumor necrosis factor-alpha (TNF-α) antagonist improves the outcome of some SCARs patients; however, this is complicated by the elusive and varied immunopathogenesis.
Aim: To investigate whether IgE antibody responses to HEMAs are associated with AD, its severity, and response to dupilumab.
Cutaneous alternariosis presenting as vasculitic ulcers.
Indian J Dermatol Venereol Leprol
October 2024
Background: High positivity rate of skin phosphorylated α-synuclein (P-SYN) was observed in Parkinson's disease (PD). Bullous pemphigoid (BP) is one of the most common autoimmune skin diseases associated with PD.
Objectives: Our aim was to investigate whether BP patients might be a targeted risk population for the screening of skin P-SYN.
Biological agents are widely used across medicine, including for immune-mediated skin conditions such as psoriasis and atopic dermatitis. When used to treat a relevant pathological process, they demonstrate impressive efficacy and credible safety, helping to achieve remission and improved function and quality of life. However, with their expanded use, awareness and understanding of adverse reactions to biologicals have also increased.
View Article and Find Full Text PDFBackground: Which cell populations that determine the fate of bacteria in infectious granulomas remain unclear. Leprosy, a granulomatous disease with a strong genetic predisposition, caused by Mycobacterium leprae infection, exhibits distinct sub-types with varying bacterial load and is considered an outstanding disease model for studying host-pathogen interactions.
Methods: We performed single-cell RNA and immune repertoire sequencing on 11 healthy controls and 20 patients with leprosy, and integrated single-cell data with genome-wide genetic data on leprosy.
Article Synopsis
- - This study examined cutaneous infections, focusing on how treatment times varied for patients with different skin lesions, specifically looking at those receiving single versus multiple drug therapies.
- - Researchers analyzed data from 35 patients, exploring their clinical characteristics and immune responses by comparing them to a group of healthy controls.
- - The findings indicated that a majority of patients had specific lesion patterns and that certain immune markers were significantly elevated in patients, suggesting potential trends that may require further investigation despite the small sample size.
Article Synopsis
- Sporotrichosis is a chronic fungal infection that affects the skin and can spread through the body's lymphatic system, with increasing prevalence and challenging treatment due to a lack of standardized diagnostics and antifungal options.!
- A new quantitative real-time PCR assay was developed to quickly diagnose sporotrichosis and identify specific species, utilizing gene sequence variations in calmodulin and internal transcribed spacer regions.!
- The assay demonstrated 100% sensitivity and specificity, accurately diagnosing S. globosa in clinical specimens, making it a valuable tool for timely and accurate diagnoses of sporotrichosis in patients.!
Background: Stapokibart/CM310, a humanized monoclonal antibody targeting the interleukin-4 receptor α chain, has shown promising treatment benefits in patients with moderate-to-severe atopic dermatitis in previous phase II clinical trials.
Objective: We aimed to evaluate the long-term efficacy and safety of stapokibart in adults with moderate-to-severe atopic dermatitis.
Methods: Enrolled patients who previously completed parent trials of stapokibart received a subcutaneous stapokibart 600-mg loading dose, then 300 mg every 2 weeks up to 52 weeks.
Article Synopsis
- Pityriasis rubra pilaris (PRP) is a skin condition marked by inflamed, scaly patches, and its exact causes are still not fully understood.
- A study involving 102 PRP patients and 800 healthy individuals found significant links between PRP and mutations in the Keratin 32 gene (KRT32), which helps regulate skin inflammation.
- These findings suggest that KRT32 mutations might contribute to PRP development by leading to increased inflammation, and highlight the potential for KRT32 as a target for new treatments.
Bullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet a comprehensive understanding of the immune landscape, particularly immune-stromal crosstalk in BP, remains elusive. Herein, using single-cell RNA sequencing (scRNA-seq) and in vitro functional analyzes, we pinpoint Th2 cells, dendritic cells (DCs), and fibroblasts as crucial cell populations. The IL13-IL13RA1 ligand-receptor pair is identified as the most significant mediator of immune-stromal crosstalk in BP.
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- Linear IgA bullous dermatosis (LABD) and dermatitis herpetiformis (DH) are types of autoimmune skin disorders linked to IgA, and this study aimed to explore their causes using serum proteomics.
- Researchers analyzed 92 biomarkers in serum samples from LABD, DH patients, and healthy controls, discovering elevated levels of certain biomarkers specific to these conditions.
- The study identified distinct biomarker clusters for LABD and DH, with six specific biomarkers showing potential for better prognosis in DH patients, which could help differentiate these disease subtypes in the future.
The burden of skin diseases in China: global burden of Disease Study 2019.
Arch Dermatol Res
May 2024
Skin diseases continue to affect human health and cause a significant disease burden on the healthcare system.We aimed to report the changing trends in the burden of skin disease in China from 1990 to 2019, Which has an important role in developing targeted prevention strategies. We applied Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 analytical tools to calculate the age-standardized Prevalence and Incidence in 2019, number of years lived with disability (YLDs) and age-standardized YLDs from 1990 to 2019 of skin and subcutaneous diseases, notifiable infectious skin diseases and skin tumors in China.
View Article and Find Full Text PDFGenetic analysis of different subtypes of aseptic pustulosis in the Chinese population.
Clin Exp Dermatol
September 2024
Article Synopsis
- Aseptic pustulosis consists of inflammatory skin conditions characterized by nonbacterial pustules and increased neutrophil and eosinophil presence in the skin.
- Research indicates that disruptions in the interleukin-36 pathway play a critical role in neutrophil aggregation and pustule development.
- The study identifies strong genetic links between IL36RN variants and various forms of aseptic pustulosis, highlighting potential therapeutic targets in the IL-1/IL-36-chemokine-neutrophil pathway.