Multi-omics integration and machine learning identify and validate neutrophil extracellular trap-associated gene signatures in chronic rhinosinusitis with nasal polyps.

This study aimed to explore the molecular characteristics of neutrophil extracellular traps (NETs) in chronic rhinosinusitis with nasal polyps (CRSwNP). Differentially expressed gene analysis, weighted gene co-expression network analysis, and machine learning algorithms identified three core NETs-associated genes: CXCR4, CYBB, and PTAFR, which were significantly upregulated in CRSwNP patients. The diagnostic performance of these genes was evaluated using receiver operating characteristic (ROC) curves, and their clinical relevance was validated using multicenter data.

Voice Disorders in Patients With Discordant RFS and RSI Scores.

Background: Laryngopharyngeal reflux (LPR) is a significant risk factor for various voice disorders. The reflux finding score (RFS) and Reflux Symptom Index (RSI) are widely used diagnostic tools for LPR, but they often show poor concordance. It remains unclear whether patients with discordant RFS and RSI scores (one positive, one negative) have a higher risk of developing voice disorders, and whether proton pump inhibitor (PPI) therapy can improve voice quality in this subgroup.

Ultrasonic head-mounted device spatiotemporal opening blood-brain barrier enhances the brain permeation of drugs for treatment of radiation-induced brain injury.

The field of physical therapy is advancing and using focused ultrasound to deliver drugs into the brain gains growing interest. However, the blood-brain barrier makes it difficult for drugs to enter. Finding safe and efficient physical therapy strategies to complement drug treatments is essential.

β-Ionone Treatment Enhances the Antioxidant Capacity in Postharvest Broccoli ( L. var. ) by Maintaining the Levels of Bioactive Substances.

Broccoli is prone to nutrient loss during postharvest storage due to its high respiratory metabolism. In this study, we investigated the effects of 0.1 mm β-ionone on bioactive substances and antioxidant capacity during postharvest storage of broccoli.

Selective Ion Separation by Capacitive Deionization: A Comprehensive Review.

Within the last decade, in addition to water desalination, capacitive deionization (CDI) has been used for the resource recovery and selective separation of target ions in multicomponent solutions. CDI is a new technology for selectively extracting valuable metal ions from solutions using an electric field and electrode materials. Unlike traditional adsorption methods, it raises attention for its environmentally friendly process and low cost, especially for extracting valuable elements.

Fecal microbiota transplantation mitigates postdieting weight regain in mice by modulating the gut-liver axis.

Background: Dysbiosis of the microbiome is strongly associated with weight rebound after dieting. However, the interactions between the host and microbiome and their relevance to the pathogenesis of post-diet weight rebound remain unclear.

Purpose: This study aimed to evaluate the effects of fecal microbiota transplantation (FMT) on post-diet weight regain and to investigate the underlying mechanisms by which FMT inhibits weight regain.

Decoding Alzheimer's Disease With Depression: Molecular Insights and Therapeutic Target.

The purpose of this study was to recognise predictive biomarkers and explore the promising therapeutic targets of AD with depression. We confirmed a positive correlation between AD and depression through MR Analysis. Through WGCNA analysis, we identified 1569 genes containing two modules, which were most related to AD.

Organelle interplay in cardiovascular diseases: Mechanisms, pathogenesis, and therapeutic perspectives.

Cardiovascular diseases (CVDs) are the leading cause of rising morbidity and mortality among humans worldwide; however, our approach to the pathogenesis, exploration, and management of CVDs still remains limited. As the heart consists of cardiomyocytes, cardiac fibroblasts, endothelial cells, smooth muscle cells, and several types of cells, different types of dysfunction in the interplay between organelles play an important damaging role, resulting in cardiac pathologies. The interplay between cellular organelles is intricate and vital for maintaining cellular homeostasis, as highlighted by multiple diseases linked to the dysfunction of both organelles.

Near-infrared light triggered bio-inspired enhanced natural silk fibroin nanofiber composite scaffold for photothermal therapy of periodontitis.

Periodontitis is one of the major oral health issues worldwide, with significant impacts on oral health and patients's quality of life, but current therapies have not achieved optimal regeneration of periodontal tissue. This study developed scaffolds using natural tussah silk fibroin (TSF) cross-linked with regenerated silk fibroin (SF) nanofibers to improve mechanical properties and wet-state stability. Zinc oxide (ZnO) and polydopamine (PDA) composite nanoparticles were loaded into scaffold to impart its antibacterial and photothermal properties to construct a photo-responsive composite scaffold (ZnO/PDA/TSF-SF).

Integrated analysis of genome-wide copy number variation and exome-wide rare variation identified novel loci for rheumatoid arthritis.

Objectives: The genetic underpinnings of RA remain partially elucidated, motivating our exploration of copy number variations (CNV) and rare variations in the pathogenesis of RA.

Methods: We conducted an integrated analysis of the genome-wide landscape of CNV and exome-wide rare variation associations with RA in the UK Biobank. To strengthen our findings, we corroborated the results by the differentially expressed genes identified from gene expression profiles of synovial tissue of RA patients and health controls.

CRSP8-driven fatty acid metabolism reprogramming enhances hepatocellular carcinoma progression by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling.

Background: In-depth exploration into the dysregulation of lipid metabolism in hepatocellular carcinoma (HCC) has contributed to the development of advanced antitumor strategies. CRSP8 is a critical component of mediator multiprotein complex involved in transcriptional recruiting. However, the regulatory mechanisms of CRSP8 on fatty acid metabolism reprogramming and HCC progression remain unclear.

Mendelian randomization-based observational cohort study on drug targets: Impact of antihypertensive and lipid-lowering therapies on inflammatory cytokines.

This study assesses the causal effects of antihypertensive and lipid-lowering drugs on inflammatory cytokines using a Mendelian randomization (MR) approach. We conducted a drug-targeted MR analysis using data from large-scale genome-wide association studies and eQTL datasets. SNPs near drug target genes served as instrumental variables to investigate the impact of antihypertensive (angiotensin-converting enzyme inhibitors [ACEIs], ARBs) and lipid-lowering drugs (HMGCR inhibitors, proprotein convertase subtilisin/Kexin type 9 [PCSK9] inhibitors, Niemann-Pick C1-like 1 inhibitors) on inflammatory cytokines.

Associations between environmental air pollution, greenspace and apparent biological aging: a cross-sectional study.

Aging is a driving factor of various non-communicable diseases. Air pollution and greenspace also affect human health to varying degrees. However, the relationship between air pollution, green space and aging has not been clearly studied.

Structure-Based Optimization of Moracin M as Potent and Selective PDE4 Inhibitors with Antipsoriasis Effects.

Psoriasis is a complex chronic inflammatory disease that severely affects the quality of life of patients. However, current medications could only control the symptoms but not cure psoriasis with unmet medical needs. Herein, structure-based optimizations of natural product moracin M (IC of 2.

Pseudomonas aeruginosa promoted microbial fuel cells for cytidine acid production wastewater treatment.

Microbial fuel cell (MFC) can convert the chemical energy of organic matter in wastewater into electrical energy with high degradation efficiency. In this study, a type of specialized microorganism, Pseudomonas aeruginosa, was screened and added to an MFC to promote the degradation of wastewater generated during the production of cytidine acid while improving the performance of the MFC. The MFC achieved a maximum voltage of 57.

Exploration of cfDNA landscape in NIPT and clinical utilities of cfDNA based gene expression inference in prenatal diagnostics.

Cell-free DNA (cfDNA) is a dynamic biomarker reflecting the physiological state of the body. Its unique physical and biochemical properties, inherited from the tissue of origin, enable a wide range of clinical applications. From methylation patterns and fragmentation profiles to genetic variants, cfDNA holds immense potential for diagnosing and monitoring various diseases, including cancer.

Fecal microbiota transplantation for the treatment of intestinal and extra-intestinal diseases: Mechanism basis, clinical application, and potential prospect.

To review the theoretical basis and therapeutic effects of fecal microbiota transplantation (FMT) in various diseases in animal experiments and clinical studies, as well as the limitations and current standards of FMT application. PubMed and Web of Science databases were searched for articles published only in English between 1975 and 2023 on reliable results of animal experiments and clinical treatment of FMT. The properties of the gut microbiota and its interactions with the host metabolism are critical to human health, and microbiome disturbance is closely associated with human intestinal and extra-intestinal diseases.

A novel deacetylase inhibitor KLX suppresses liver fibrosis by deacetylating PPARγ through promoting ubiquitination-mediated HDAC1 degradation.

Liver fibrosis is a pathological response following liver injury induced by various etiologies. Herein, we present the therapeutic potential of a novel anthraquinone compound, kanglexin (KLX), in the treatment of liver fibrosis. We observed significant suppression of the inflammatory response and extracellular matrix deposition in mice with liver fibrosis induced by CCL, by bile duct ligation, and by a methionine-choline-deficient diet.

LncRNA TCONS_00067339 as a key regulatory factor inducing decreased cell viability and ferroptosis in neonatal hypoxic-ischemic brain damage.

Newborn hypoxic-ischemic brain damage (HIBD) is a major cause of mortality and neurological disabilities. Ferroptosis, characterized by lipid peroxidation, is implicated in HIBD pathogenesis. The role of lncRNA TCONS_00067339 in ferroptosis regulation in HIBD is understudied.

Akkermansia muciniphila protects against dopamine neurotoxicity by modulating butyrate to inhibit microglia-mediated neuroinflammation.

Parkinson's disease (PD) is an age-related and second most common neurodegenerative disease. To date, safe and efficient therapeutic drugs are deficient. In recent years, the relationship between gut microbiota and CNS have received more attention.

Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex.

Background: Lung cancer is a common malignant neoplasm, one of the leading causes of death worldwide. Cancer stem cells (CSCs) drive tumor recurrence, progression, and therapeutic resistance. Thus, targeting CSCs may contribute to lung cancer treatment and improve clinical outcomes.

Chemical exposure in females of childbearing age associated with sex hormones: Evidence from an untargeted exposomic approach.

Exposure to organic chemicals can cause reproductive hormones disturbance in women. However, there is very limited evidence regarding real-world chemical exposures in reproductive-aged women and their joint effects on sex hormone levels. Here, we applied non-targeted screening workflow based on High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry to investigate the serum chemical exposome of 156 women of childbearing age from Jinan, China.

Development of a Melting Point Depression Method to Measure the Solubility of a Small-Molecule Drug in Poly-Lactic-co-Glycolic Acid (PLGA).

Purpose: The solubility of a crystalline drug in a polymer is commonly determined by measuring melting point depression with differential scanning calorimetry (DSC). The accuracy of this measurement depends on rapid dissolution of the drug into the molten polymer during the DSC heating scan. A preferred method of accelerating this dissolution process is to preblend the drug and polymer by cryo-milling.

Construction of biomass-derived magnetic-recyclable FeNi-LDO@CS to activate persulfate for simultaneous degradation of cationic and anionic dyes: Discrepancy, mechanism and toxicity analysis.

In this study, layered chitosan-based magnetic nickel ferrite NiFeO/chitosan (CS-LDO) composites were synthesized. The results show that under optimal conditions, 98 % of methylene blue (MB) and 92 % of xylenol orange (XO) can be simultaneously degraded within 120 min in the CS-LDO/persulfate (PS) system, and the removal rates of total organic carbon (TOC) and chemical oxygen demand (COD) can reach 67.32 % and 74.

Methionine-mediated trade-off between plant growth and salt tolerance.

Salt stress is an important environmental factor that limits plant growth and development. A better understanding of the molecular mechanisms underlying plant salt tolerance will help improve plant performance and crop production under saline conditions. Here, we found that the amino acid methionine significantly improves plant salt tolerance.