Sustainable calcium gluconate-based coatings for lyocell fabrics with superior flame retardancy, antibacteria and wearing properties.

Sustainability and high performance of flame retardants for lyocell fabrics were still difficult to balance. Here, the full bio-based coatings (PACG) for lyocell fabrics with superior efficient flame-retardant, antibacterial and wearing properties were prepared by phytic acid (PA) and calcium gluconate (CG) in the water solvent. The fire safety of PACG/Lyocell fabrics was remarkably enhanced with an increase in limiting oxygen index (LOI) to 28.

Gallic acid enhances GVL effects of T cells without exacerbating GVHD after haematopoietic stem cell transplantation.

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective therapy for acute myeloid leukaemia (AML), predominantly due to its potent graft-versus-leukaemia (GVL) effect. However, leukaemia relapse remains a major obstacle to the success of allo-HSCT. In this study, we demonstrated that gallic acid (GA), a natural dietary compound, can enhance T-cell-mediated GVL effects both in vitro and in vivo.

Tandem catalytic allylic C-H amination and asymmetric [2,3]-rearrangement bimetallic relay catalysis.

A bimetallic relay catalysis protocol for tandem allylic C-H amination and asymmetric [2,3]-sigmatropic rearrangement has been developed with the use of an achiral Pd catalyst and a chiral ,'-dioxide-Mg complex in a one-pot operation. A series of anti-α-amino derivatives containing two stereogenic centers were prepared from readily available allylbenzenes and glycine pyrazolamide with good yields and high stereoselectivities. Moreover, the synthetic potential of this protocol was further demonstrated by the product transformations, and a catalytic cycle was proposed to illustrate the reaction process.

[Development and characterization of tobacco suspension cell chassis NBS-1].

Plant synthetic biology has significant theoretical advantages in exploration and production of plant natural products. However, its contribution to the field of biosynthesis is currently limited due to the lack of efficient chassis systems and related enabling technologies. Synthetic biologists often avoid tobacco as a chassis system because of its long operation cycle, difficulties in genetic and metabolic modification, complex metabolism and purification background, nicotine toxicity, and challenges in accurately controlling for agricultural production.

Tandem gene duplication selected by activation of horizontally transferred gene in bacteria.

Horizontal gene transfer occurs frequently in bacteria, but the mechanism driving activation and optimization of the expression of horizontally transferred genes (HTGs) in new recipient strains is not clear. Our previous study found that spontaneous tandem DNA duplication resulted in rapid activation of HTGs. Here, we took advantage of this finding to develop a novel technique for tandem gene duplication, named tandem gene duplication selected by activation of horizontally transferred gene in bacteria (TDAH), in which tandem duplication was selected by the activation of horizontally transferred selectable marker gene.

An Exploration into the Fault Diagnosis of Analog Circuits Using Enhanced Golden Eagle Optimized 1D-Convolutional Neural Network (CNN) with a Time-Frequency Domain Input and Attention Mechanism.

With the continuous operation of analog circuits, the component degradation problem gradually comes to the forefront, which may lead to problems, such as circuit performance degradation, system stability reductions, and signal quality degradation, which could be particularly evident in increasingly complex electronic systems. At the same time, due to factors, such as continuous signal transformation, the fluctuation of component parameters, and the nonlinear characteristics of components, traditional fault localization methods are still facing significant challenges when dealing with large-scale complex circuit faults. Based on this, this paper proposes a fault-diagnosis method for analog circuits using the ECWGEO algorithm, an enhanced version of the GEO algorithm, to de-optimize the 1D-CNN with an attention mechanism to handle time-frequency fusion inputs.

Enhancement Methods of Hydropower Unit Monitoring Data Quality Based on the Hierarchical Density-Based Spatial Clustering of Applications with a Noise-Wasserstein Slim Generative Adversarial Imputation Network with a Gradient Penalty.

In order to solve low-quality problems such as data anomalies and missing data in the condition monitoring data of hydropower units, this paper proposes a monitoring data quality enhancement method based on HDBSCAN-WSGAIN-GP, which improves the quality and usability of the condition monitoring data of hydropower units by combining the advantages of density clustering and a generative adversarial network. First, the monitoring data are grouped according to the density level by the HDBSCAN clustering method in combination with the working conditions, and the anomalies in this dataset are detected, recognized adaptively and cleaned. Further combining the superiority of the WSGAIN-GP model in data filling, the missing values in the cleaned data are automatically generated by the unsupervised learning of the features and the distribution of real monitoring data.

Research on Denoising Method for Hydroelectric Unit Vibration Signal Based on ICEEMDAN-PE-SVD.

Vibration monitoring and analysis play a crucial role in the fault diagnosis of hydroelectric units. However, accurate extraction and identification of fault features from vibration signals are challenging because of noise interference. To address this issue, this study proposes a novel denoising method for vibration signals based on improved complementary ensemble empirical mode decomposition with adaptive noise (ICEEMDAN), permutation entropy (PE), and singular value decomposition (SVD).

Photoredox-catalyzed diastereoselective dearomative prenylation and reverse-prenylation of electron-deficient indole derivatives.

Prenylated and reverse-prenylated indolines are privileged scaffolds in numerous naturally occurring indole alkaloids with a broad spectrum of important biological properties. Development of straightforward and stereoselective methods to enable the synthesis of structurally diverse prenylated and reverse-prenylated indoline derivatives is highly desirable and challenging. In this context, the most direct approaches to achieve this goal generally rely on transition-metal-catalyzed dearomative allylic alkylation of electron-rich indoles.

Zearalenone Exposure Disrupts STAT-ISG15 in Rat Colon: A Potential Linkage between Zearalenone and Inflammatory Bowel Disease.

Zearalenone (ZEN), a prevalent mycotoxin contaminating food and known for its intestinal toxicity, has been suggested as a potential risk factor for inflammatory bowel disease (IBD), although the exact relationship between ZEN exposure and IBD remains unclear. In this study, we established a rat model of colon toxicity induced by ZEN exposure to investigate the key targets of ZEN-induced colon toxicity and explore the underlying connection between ZEN exposure and IBD. Histological staining of the rat colon revealed significant pathological changes resulting from ZEN exposure ( < 0.

Circulating microRNAs as diagnostic biomarkers for melanoma: a systematic review and meta-analysis.

Background: Recent studies have shown that circulating microRNAs (miRNAs) can be used as diagnostic biomarkers for melanoma. This study aimed to evaluate the diagnostic value of circulating miRNAs for melanoma.

Methods: A comprehensive literature search was conducted and the quality of the included literature was evaluated using QUADAS-2 (Quality Assessment for diagnostic accuracy studies), and the diagnostic accuracy was assessed by pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC).

[Pathogenesis of glucocorticoid-induced osteoporosis based on label-free mass proteomics].

Objective: To explore pathogenesis of glucocortocoid-induced osteoporosis(GIOP) based on label-free mass proteomics.

Methods: Twevle female Sprague-Dawley(SD) rats were randomly divided into two groups, named as sham group and GIOP group. After one-week adaptive feeding, the rats of GIOP group were administered with dexamethasone via intramuscular injection according to 2.

ZeXie decoction alleviates non-alcoholic fatty liver disease in rats: the study of genes, lipids, and gut microbiotas.

Recently, with increasing awareness of health issues, non-alcoholic fatty liver disease (NAFLD) has become an epidemic attracting global attention. As a serious chronic disease, NAFLD is clinically managed with pharmacological interventions that are usually associated with poor long-term efficacy and adverse effects. In this scenario, traditional Chinese medicine (TCM) characterized by "multiple ingredients-multiple targets-multiple pathways" shows promise as a potential option to treat NAFLD.

Patients with melanoma treated with immune checkpoint inhibitors who had non-thyroid endocrine and skin immune-related adverse events have better prognosis: A systematic review and meta-analysis.

Background: Several studies have reported an association between the occurrence of immune-related adverse events (irAEs) and prognosis in patients with melanoma treated with immune checkpoint inhibitors (ICIs), but the results remain controversial. We conducted a systematic review and meta-analysis to investigate the association between irAEs and survival in patients with melanoma treated with ICIs.

Methods: We searched the PubMed, Web of Science, and China National Knowledge Infrastructure databases through May 5, 2022 for clinical studies evaluating the association between irAEs and in melanoma patients treated with ICIs.

Diastereo- and Enantioselective Construction of Vicinal All-Carbon Quaternary Stereocenters via Iridium/Europium Bimetallic Catalysis.

The diastereo- and enantioselective construction of vicinal all-carbon quaternary stereocenters is a formidable task. We here report a synergistic bimetallic catalysis via a chiral N,N'-dioxide-europium (Eu) complex and a phosphoramidite-iridium (Ir) catalyst for the asymmetric allylation of oxindole derivatives by using challenging trisubstituted allylic esters. The allylated products bearing vicinal all-carbon quaternary stereocenters were obtained with good diastereoselectivities (up to 20 : 1 dr) and excellent enantioselectivities (up to 99 % ee).

Zearalenone-14-Glucoside Is Hydrolyzed to Zearalenone by β-Glucosidase in Extracellular Matrix to Exert Intracellular Toxicity in KGN Cells.

As one of the most important conjugated mycotoxins, zearalenone-14-glucoside (Z14G) has received widespread attention from researchers. Although the metabolism of Z14G in animals has been extensively studied, the intracellular toxicity and metabolic process of Z14G are not fully elucidated. In this study, the cytotoxicity of Z14G to human ovarian granulosa cells (KGN) and the metabolism of Z14G in KGN cells were determined.

Total Flavonoids of Drynariae Rhizoma Improve Glucocorticoid-Induced Osteoporosis of Rats: UHPLC-MS-Based Qualitative Analysis, Network Pharmacology Strategy and Pharmacodynamic Validation.

Background: Glucocorticoid-induced osteoporosis (GIOP) is a common form of secondary osteoporosis caused by the protracted or a large dosage of glucocorticoids (GCs). Total flavonoids of Drynariae rhizoma (TFDR) have been widely used in treating postmenopausal osteoporosis (POP). However, their therapeutic effects and potential mechanism against GIOP have not been fully elucidated.

Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultrahigh-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resistance-associated protein 2 in the vesicular transport assay.

Shengjiang Xiexin decoction, a traditional Chinese medical formula, has been utilized to alleviate the delayed-onset diarrhea induced by irino tecan. However, the chemical constituents of this formula and the activities of its constituents remain unclear. In this study, ultrahigh-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry was employed to comprehensively analyze the chemical constituents of Shengjiang Xiexin decoction.

Intelligent Optimization of Tower Crane Location and Layout Based on Firefly Algorithm.

The existing tower crane positioning layout mainly depends on the experience of construction personnel, and the best tower crane positioning can be found through a large number of manual data calculation. This manual method is time-consuming and impractical. In view of this, aiming at the current situation that building information modeling (BIM) software can only obtain the relative coordinates of components, this article puts forward the key technology of importing computer-aided design (CAD) graphics into geographic information system (GIS) software to automatically obtain the world coordinate information.

Enantioselective construction of -hydroindole scaffolds an asymmetric inverse-electron-demand Diels-Alder reaction: application to the formal total synthesis of (+)-minovincine.

-Hydroindole scaffolds widely exist in a large number of natural products, pharmaceuticals, and organocatalysts. Therefore, the development of efficient and enantioselective methods for the construction of -hydroindoles is of great interest and importance. Herein, a novel approach for the enantioselective synthesis of -hydroindole scaffolds has been realized through a chiral ,'-dioxide/Mg(OTf) complex catalyzed asymmetric inverse-electron-demand Diels-Alder (IEDDA) reaction of 2-pyrones and cyclic enamines.

Integration strategy of network pharmacology in Traditional Chinese Medicine: a narrative review.

Traditional Chinese Medicine (TCM) has been extensively used as a mainstay for treating various pathologies. Combing the pharmacology and systems biology approaches, the network pharmacology (NP) approach was developed to predict the probable mechanism underlying the therapeutic effect of TCM. However, approaches solely based on NP cannot effectively elucidate the curative mechanism in a holistic and reliable manner due to limitations in NP-based methods and complexity of TCM components.

Qualitative Analysis of Drug-Containing Plasma and its Application to Quantitative Analysis and Pharmacokinetic Study of Zexie Decoction Using UPLC-MS/MS.

ZeXie Decoction (ZXD) is one of the traditional Chinese medicine formulas (TCMFs) comprising (Sam.) Juzep. (ZX) and Koidz.

Bimetallic Palladium/Cobalt Catalysis for Enantioselective Allylic C-H Alkylation via a Transient Chiral Nucleophile Strategy.

An asymmetric allylic C-H functionalization has been developed by making use of transient chiral nucleophiles, as well as bimetallic synergistic catalysis with an achiral Pd catalyst and a chiral N,N'-dioxide-Co complex. A variety of β-ketoesters and N-Boc oxindoles coupled with allylbenzenes and aliphatic terminal alkenes were well tolerated, furnishing the desired allylic alkylation products in high yields (up to 99 %) with excellent regioselectivities and enantioselectivities (up to 99 % ee).

A Strategy for Screening the Lipid-Lowering Components in Decoction Based on Spectrum-Effect Analysis.

decoction (ARD), comprised of (Sam.) Sam and Koidz. at a ratio of 5 : 2, is a classic traditional Chinese medicine (TCM) formula with successful clinical hypolipidemic effect.

Integrating Network Pharmacology and RT-qPCR Analysis to Investigate the Mechanisms Underlying ZeXie Decoction-Mediated Treatment of Non-alcoholic Fatty Liver Disease.

ZeXie Decoction (ZXD) is a traditional Chinese medicine composed of (Sam.) Juzep. and Koidz.