North American Fine Particulate Matter Chemical Composition for 2000-2022 from Satellites, Models, and Monitors: The Changing Contribution of Wildfires.

Air quality management benefits from an in-depth understanding of the emissions associated with, and composition of, local PM concentrations. Here, we investigate the changing role of biomass burning emissions to North American PM exposure by combining multiple satellite-, ground-, and simulation-based data sets biweekly at a 0.01° × 0.

Construction of a disulfidptosis-related lncRNAs signature of the subtype, prognostic, and immunotherapy in neuroblastoma.

Background: Disulfidptosis is an emerging form of regulated cell death distinguished by abnormal disulfide stress and the collapse of the actin network. This study was to construct a prognostic model based on disulfidptosis-related lncRNAs (DRLs) to enhance survival prediction and assess their viability as biomarkers for immunotherapy response in neuroblastoma (NB).

Methods: Transcriptomic and clinical data from NB patients were obtained from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) databases.

Interferon Gamma Receptor 2 Collaborates With Circular RNA/MicroRNA to Modulate Programmed Cell Death-Ligand 1 Levels in Nasopharyngeal Carcinoma.

Background: The effectiveness of immune checkpoint therapy highlights the need to understand abnormal programmed cell death protein-1 (PD-1) expression in nasopharyngeal carcinoma (NPC), especially when treatments fail, or resistance develops. Interferon gamma (IFN-γ) signaling is crucial for regulating programmed cell death-ligand 1 (PD-L1) expression. Our study focuses on interferon gamma receptor 2 (IFNGR2), an essential part of the IFN-γ pathway, and its impact on malignant traits in NPC.

Alternative splicing regulation by tumor suppressing subtransferable candidate 4: a pathway to tumor suppression.

Introduction: RNA splicing is a crucial posttranscriptional process that governs gene expression, and defects in alternative splicing contribute to various diseases, including cancer. Tumor suppressing subtransferable candidate 4 (TSSC4) is a known tumor suppressor and has been identified as part of the U5 small nuclear ribonucleoprotein (snRNP), which is involved in tri-snRNP biogenesis. However, the precise role of TSSC4 in regulating alternative splicing and its impact on tumor growth remain unclear.

DSCONV-GAN: a UAV-BASED model for Verticillium Wilt disease detection in Chinese cabbage in complex growing environments.

Verticillium wilt greatly hampers Chinese cabbage growth, causing significant yield limitations. Rapid and accurate detection of Verticillium wilt in the Chinese cabbage (Brassica rapa L. ssp.

Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective cohort study.

Background: Recent phase III randomized controlled trials have demonstrated that first-line immune checkpoint inhibitors (ICIs) improve prognosis in advanced HER-2-negative gastric cancer patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) higher than 5. However, these findings are not confirmed in real-world settings, and the benefits in PD-L1 CPS < 5 patients remain controversial.

Methods: In this multicenter, retrospective cohort study, data from across thirteen medical centers were analyzed by inverse probability of treatment weighting for matching, alongside univariate and multivariate COX proportional hazard regression models.

The 24-kDa subunit of mitochondrial complex I regulates growth, microsclerotia development, stress tolerance, and virulence in Verticillium dahliae.

Background: The complete mitochondrial respiratory chain is a precondition for maintaining cellular energy supply, development, and metabolic balance. Due to the evolutionary differentiation of complexes and the semi-autonomy of mitochondria, respiratory chain subunits have become critical targets for crop improvement and fungal control. In fungi, mitochondrial complex I mediates growth and metabolism.

Association between blood heavy metals and fecal incontinence in American adults: A population-based study.

Background: Previous studies have revealed the impact of heavy metals (HMs) on gut microbiota and intestinal structure. However, the relationship between HMs and fecal incontinence (FI) remains unclear. Therefore, this study aims to evaluate the association between blood HMs exposure and FI.

Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder.

Objective: Major depressive disorder (MDD) is known to be characterized by disrupted brain functional network connectivity (FNC) patterns, while the dynamic change mode of different functional networks is unclear. This study aimed to characterize specific dynamic alterations pattern on intrinsic FNC in MDD by combining static FNC (sFNC) and dynamic FNC (dFNC).

Methods: A total of 48 first-episode drug-naïve MDD and 48 matched healthy controls (HCs) were included in this study.

A genotype-guided prediction model for the incidence of persistent acute kidney injury following lung transplantation.

Background: This study aimed to develop a nomogram for predicting persistent renal dysfunction in acute kidney injury (AKI) following lung transplantation (LTx).

Method: A total of 229 LTx patients were enrolled, and genotyping for 153 single nucleotide polymorphisms (SNPs) was performed. The cohort was randomly divided into training (n = 183) and validation (n = 46) sets in an 8:2 ratio.

Identification of GiOMT gene family in Glycyrrhiza inflata bat and expression analysis under UV-B stresses.

Background: O-Methyltransferase (OMTs) is a class of conserved multifunctional enzymes that play important roles in plant developmental regulation, hormone signaling, secondary metabolite synthesis and abiotic stress response. The GiOMT gene family has been identified and analyzed in species such as citrus, alfalfa, Populus and grape, but has not been reported in Glycyrrhiza inflata Bat.

Results: In this study, we systematically identified and analyzed the GiOMT gene family of G.

Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients' populations.

Background: No authoritative books or guidelines are currently available for revealing the interrelationships of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa). Moreover, no consensus on this issue has been reached among previously published epidemiological studies or meta-analyses.

Purpose: We first took advantage of Mendelian randomization to clarify this issue and provide clinical implications for these patients' populations.

Unlocking academic achievement of nursing master's students: ethical leadership, teacher-student relationship and growth mindset - a cross-sectional survey study.

Background: Academic achievement is a critical indicator of teaching quality. There has been limited exploration into the mechanisms underlying academic achievements among nursing master's students. This study investigated the relationship between ethical leadership and academic achievements, focusing on how the teacher-student relationship and growth mindset mediate this relationship.

Antibiotics versus Non-Antibiotic in the treatment of Aspiration Pneumonia: analysis of the MIMIC-IV database.

Background: Aspiration pneumonia (AP) is a common complication in the intensive care unit (ICU), which is associated with significantly increased morbidity and mortality and has a significant impact on patient prognosis. Antibiotics are commonly used in the clinical treatment of AP. However, the prognostic impact of antibiotics on patients with AP has not been adequately characterized.

Disorder-specific neurodynamic features in schizophrenia inferred by neurodynamic embedded contrastive variational autoencoder model.

Neurodynamic models that simulate how micro-level alterations propagate upward to impact macroscopic neural circuits and overall brain function may offer valuable insights into the pathological mechanisms of schizophrenia (SCZ). In this study, we integrated a neurodynamic model with the classical Contrastive Variational Autoencoder (CVAE) to extract and evaluate macro-scale SCZ-specific features, including subject-level, region-level parameters, and time-varying states. Firstly, we demonstrated the robust fitting of the model within our multi-site dataset.

Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8CD69 T cells.

Background: Liver metastasis is highly aggressive and immune tolerant, and lacks effective treatment strategies. This study aimed to develop a neoantigen hydrogel vaccine (NPT-gels) with high clinical feasibility and further investigate its efficacy and antitumor molecular mechanisms in combination with immune checkpoint inhibitors (ICIs) for the treatment of liver metastases.

Methods: The effects of liver metastasis on survival and intratumor T-cell subpopulation infiltration in patients with advanced tumors were investigated using the Surveillance, Epidemiology, and End Results Program (SEER) database and immunofluorescence staining, respectively.

Electrochemical Behaviors of Ultramicro Triangular Pipettes.

Ultramicro pipettes with circular orifices have practically become common probes in exploring the microscopic world, yet the versatility of differently shaped pipettes is undermined in the pore family. Herein, ultramicro triangular pipettes with a pseudotriangular-shaped orifice were fabricated by laser-pulling triangular quartz capillaries and characterized by microscopic and electrochemical methods. Then, the differences in the electrochemical behaviors of triangular and circular pores were revealed through experiments and simulations.

Near infrared laser precisely controlled ultrafast superhydrophilicity-to-hydrophobicity transition of copper sulfide nanosphere coating on cellulose fiber fabric.

Inspired by lotus leaf, biomimetic hydrophobic cellulose fiber-based textiles were usually fabricated by the lower surface energy materials. However, it is rare to witness a hydrophobic surface obtained by near infrared laser (NIR) irradiation a superhydrophilic nanomaterial, which remains a huge challenge. Herein, the CuS nanospheres was in-situ anchored on the surface of gallic acid self-polymer treated cotton fabric.

Unraveling asymmetrical spillover effects originating from China's green finance markets: Insights from asymmetric TVP-VAR and interpretable machine learning.

This study combines an asymmetric TVP-VAR model with interpretable machine learning algorithms to confirm the presence of asymmetries in spillover effects within China's green finance market and to identify the macroeconomic drivers behind these effects. The key findings are as follows: First, China's green finance market has become a prominent transmitter of energy risk spillovers, with a significant asymmetry in its external effects-negative return spillovers exceed positive ones. This asymmetry is especially evident during extreme events like the 2014 oil price crash and the COVID-19 pandemic, indicating that investors in this market are more responsive to negative news.

Polysaccharides as natural enhancers for meat quality, preservation, and protein functionality: A comprehensive review.

Recent research focuses on developing meat products with health-promoting properties to reduce disease risk, particularly using natural polysaccharides due to their antioxidant and antibacterial effects. These polysaccharides, sourced from various materials, act through diverse structural mechanisms, inhibiting pathogen growth, enhancing oxidative stability, and improving meat flavor. This study highlights the role of meat proteins in achieving the Sustainable Development Goals (SDGs) and their importance in enhancing processed meat quality.

Sorption behavior of oxytetracycline on microplastics and the influence of environmental factors in groundwater: Experimental investigation and molecular dynamics simulation.

Microplastics (MPs) and antibiotics can enter groundwater through the interaction of soil and surface water, and MPs as carriers of antibiotics can promote the migration of antibiotics and thus generate more serious ecological risks. Therefore, this paper used experimental and molecular dynamics (MD) simulation methods to investigate the sorption between four common types of MPs in groundwater, namely polyamide (PA), polystyrene (PS), polyvinyl chloride (PVC), and polyethylene (PE), and oxytetracycline (OTC) with high detection rate in groundwater. Additionally, the impact of environmental factors on sorption was examined.

Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression.

TNBC, the most aggressive form of breast cancer, lacks accurate and effective therapeutic targets. Immunotherapy presents a promising approach for addressing TNBC. Anxiety and depression are frequently concurrent symptoms in TNBC patients.

Interferon-stimulated gene subtypes as key indicators of immune landscape and survival outcomes in ovarian cancer.

Purpose: Ovarian cancer (OV) remains the most lethal gynecological malignancy, underscoring the critical need for robust prognostic biomarkers to enhance patient outcomes. In this study, we classified OV patients by their interferon-stimulated gene (ISG) expression profiles and investigated the associations between these subtypes, the immune microenvironment, and survival outcomes.

Methods: We employed consensus clustering in the TCGA-OV cohort (n = 376) to classify patients into ISG-related subgroups.

Clinical outcomes and safety of CAR-T cells in treatment of T-Cell acute lymphoblastic leukemia/lymphoma.

Relapsed or refractory T-cell acute lymphoblastic leukemia/lymphoma (r/r T-ALL/LBL) are frequently aggressive and associated with unfavorable prognoses. Pan-targeted Chimeric Antigen Receptor (CAR) T-cell therapy have shown promising results in clinical trials. In recent years, CD7 CAR T-cell and CD5 CAR T-cell demonstrate effectiveness in treating r/r T-ALL/LBL patients with bone marrow infiltration.

Application of Circulating Tumor DNA in the Auxiliary Diagnosis and Prognosis Prediction of Glioma.

Glioma is the most common primary malignant brain tumor. Despite significant advances in the past decade in understanding the molecular pathogenesis of this tumor and exploring therapeutic strategies, the prognosis of patients with glioma remains poor. Accurate diagnosis of glioma is very important for the treatment and prognosis.