Cotton RLP6 Interacts With NDR1/HIN6 to Enhance Verticillium Wilt Resistance via Altering ROS and SA.

Cotton Verticillium wilt (VW) is often a destructive disease that results in significant fibre yield and quality losses in Gossypium hirsutum. Transferring the resistance trait of Gossypium barbadense to G. hirsutum is optional but challenging in traditional breeding due to limited molecular dissections of resistance genes.

Sex Differences in Long COVID.

Importance: A substantial number of individuals worldwide experience long COVID, or post-COVID condition. Other postviral and autoimmune conditions have a female predominance, but whether the same is true for long COVID, especially within different subgroups, is uncertain.

Objective: To evaluate sex differences in the risk of developing long COVID among adults with SARS-CoV-2 infection.

New Algorithms to Generate Permutationally Invariant Polynomials and Fundamental Invariants for Potential Energy Surface Fitting.

Symmetric functions, such as Permutationally Invariant Polynomials (PIPs) and Fundamental Invariants (FIs), are effective and concise descriptors for incorporating permutation symmetry into neural network (NN) potential energy surface (PES) fitting. The traditional algorithm for generating such symmetric polynomials has a factorial time complexity of , where is the number of identical atoms, posing a significant challenge to applying symmetric polynomials as descriptors of NN PESs for larger systems, particularly with more than 10 atoms. Herein, we report a new algorithm which has only linear time complexity for identical atoms.

Guided bone regeneration therapy based on plaque control of peri-implantitis with follow-up at 7 years.

Peri-implantitis is a pathologic condition associated with dental plaque that occurs in the implant tissue and is characterized by inflammation of the mucous membrane surrounding the implant, followed by the progressive loss of supporting bone. In this study, a case of guided bone regeneration therapy based on plaque control of peri-implant inflammation was reported. Four years after surgery for the left second premolar implant, the patient presented with "left lower posterior tooth swelling and discomfort for more than 2 years".

Predictive and prognostic nomogram models for liver metastasis in colorectal neuroendocrine neoplasms: a large population study.

Background: In recent years, the incidence of patients with colorectal neuroendocrine neoplasms (CRNENs) has been continuously increasing. When diagnosed, most patients have distant metastases. Liver metastasis (LM) is the most common type of distant metastasis, and the prognosis is poor once it occurs.

AFAP targets the host nucleolus and inhibits induced apoptosis.

, the etiologic agent of human granulocytic anaplasmosis (HGA), is an obligate intracellular Gram-negative bacterium. During infection, transfers its type IV secretion system (T4SS) effector proteins into host cells to manipulate cellular processes. AFAP (an actin filament-associated protein) was identified as a T4SS effector protein and found to interact with the host nucleolin, as described in a previous study.

Thalamic functional connectivity on 7-Tesla magnetic resonance imaging and its relation to motor signs in early-stage Parkinson's disease.

Background: It is well known that dysfunction of thalamocortical circuity generates the motor signs that lead to distinct disease processes and prognoses in Parkinson's disease (PD). This study aimed to leverage ultrahigh-field magnetic resonance imaging (MRI) to identify the connectivity alterations of thalamocortical circuity and clarify their relation to motor signs in early PD.

Methods: Patients with early-stage PD (n=55) and healthy controls (HCs, n=56) were recruited from March 2022 to July 2023.

2D Van der Waals Sliding Ferroelectrics Toward Novel Electronic Devices.

Ferroelectric materials, celebrated for their switchable polarization, have undergone significant evolution since their early discovery in Rochelle salt. Initial challenges, including water solubility and brittleness, are overcome with the development of perovskite ferroelectrics, which enable the creation of stable, high-quality thin films suitable for semiconductor applications. As the demand for miniaturization in nanoelectronics has increased, research has shifted toward low-dimensional materials.

CRISPR/Cas13a-Enhanced Porous Hydrogel Encapsulated Photonic Barcodes for Multiplexed Detection of Virus.

In this study, we present an ultrasensitive and specific multiplexed detection method for SARS-CoV-2 and influenza (Flu) utilizing CRISPR/Cas13a technology combined with a hydrogel-encapsulated photonic crystal (PhC) barcode integrated with hybridization chain reaction (HCR). The barcodes, characterized by core-shell structures, are fabricated through partial replication of periodically ordered hexagonally close-packed silicon dioxide beads. Consequently, the opal hydrogel shell of these barcodes features abundant interconnected pores that provide a substantial surface area for probe immobilization.

Analysis of a case of pilomatricoma in an adolescent after receiving recombinant hepatitis B vaccine (CHO cell) in Beijing of China.

We report and analyze a case of pilomatricoma in an adolescent after receiving recombinant hepatitis B vaccine (CHO cell) in Chaoyang District of Beijing and to evaluate the causality between the disease and vaccination. Based on the professional branch of this case, we organized a seminar and we invited specialists in vaccinology, epidemiology, dermatology, infectiology, and immunology to participate in the conference. Specialists evaluated the relevance and causality between the vaccination and disease.

Explainable machine learning models for identifying mild cognitive impairment in older patients with chronic pain.

Background: Mild cognitive impairment (MCI) is prevalent in older adults with chronic pain, making early detection crucial for dementia prevention and healthy aging. This study aimed to determine MCI risk factors in older patients with chronic pain and to develop 9 machine learning models to identify MCI risk.

Methods: A total of 612 older patients with chronic pain were recruited between October 2023 and July 2024.

Tolerance and accumulation characteristics of Brassica chinensis L. under the interactive treatments of lanthanum, cerium, and fluorine in soil.

The extensive mining of bastnasite (CeFCO) has caused severe pollution of lanthanum (La), cerium (Ce), and fluorine (F) in the surrounding farmland soil, threatening the safety of the soil-plant system. However, the stress effects of the interaction among these three elements on the tolerance and accumulation traits of Brassica chinensis L. (B.

MT1/cAMP/PKA Pathway in Melatonin-Regulated Sperm Capacitation.

Melatonin is mainly synthesized and secreted by pineal gland, and plays multiple functions, including its regulating effects on reproductive processes. Sperm capacitation is necessary for fertilization, but the effect of melatonin on mouse sperm capacitation remains to be elucidated. We thus investigated the roles of melatonin on capacitation by culturing the sperms from mouse cauda epididymis in the medium with different doses of melatonin.

Atomically resolved imaging of radiation-sensitive metal-organic frameworks via electron ptychography.

Electron ptychography, recognized as an ideal technique for low-dose imaging, consistently achieves deep sub-angstrom resolution at electron doses of several thousand electrons per square angstrom (e/Å) or higher. Despite its proven efficacy, the application of electron ptychography at even lower doses-necessary for materials highly sensitive to electron beams-raises questions regarding its feasibility and the attainable resolution under such stringent conditions. Herein, we demonstrate the implementation of near-atomic-resolution ( ~ 2 Å) electron ptychography reconstruction at electron doses as low as ~100 e/Å, for metal-organic frameworks (MOFs), which are known for their extreme sensitivity.

Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States.

Racial/ethnic differences are associated with the symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These differences may exist among children and warrant further exploration. We conducted a retrospective cohort study with difference-in-differences analyzes to assess these differences in children and adolescents under the age of 21.

Modification mechanism of potato protein by twin-screw extrusion from the perspective of temperature variation.

Potato protein has attracted much attention due to its unique nutritional and structural properties. In this study, the twin-screw extrusion technology was employed to modify potato protein, while the modification mechanism was investigated from the perspective of temperature variation. Results indicated that extruded potato protein (EPP) led to the extremely significantly decreased surface hydrophobicity (1350 to 307-396) and foaming capacity (41.

Robust yet Self-Healing Multimodal Actuators Enabled by Noncovalent Assembled Nanostructure.

In nature, animals can realize multimodal movements such as walking, climbing, and jumping through transformation in locomotor gaits or form for survival, which is highly desired for untethered flexible actuators yet remains challenging. Here, we propose a robust self-healing multimodal actuator enabled by noncovalent assembled nanostructures with elaborate regulation of multistage responsive behaviors. Owing to the dynamic interfacial design between multiple components, the stimulus can be accurately delivered through a "light-heat-force release" pathway, endowing the actuator with diverse motion capabilities and desired jumping ability (27 cm, 34 times body length).

High-Efficiency, Long-Lifetime and Color-Tunable Hybrid WOLEDs Using a Platinum Complex with Voltage-Dependent Monomer and Aggregate Emission.

Color-tunable white organic light-emitting diodes (CT-WOLEDs) have attracted widespread attention given their large color variation to meet the different daily scenarios from the perspective of circadian rhythm. However, most reported CT-WOLEDs, especially the tri-color devices, exhibit poor performances and sophisticated structures. Here, a simple structure tri-color CT-WOLED is demonstrated that simultaneously exhibits high efficiency, ultralong operation lifetime, and wide color-tunable range for dynamic sunlight emulation.

Platelet-rich plasma alleviates skin photoaging by activating autophagy and inhibiting inflammasome formation.

Platelet-rich plasma (PRP) holds promising prospects for the treatment of skin photoaging. This study aims to unravel the mechanism underlying PRP's anti-photoaging properties. Partial skin of rats was irradiated with ultraviolet (UV) and injected with PRP, and the skin appearance, pathological state, and aging conditions were determined.

Analysis of Outcomes and Factors Influencing Community-Acquired Pressure Injury: A Retrospective Review of 413 Patients.

Purpose: The purpose of this study was to analyze the outcomes and influencing factors of patients with community-acquired pressure injuries (CAPIs) and provide insights for clinical practice.

Design: Retrospective cohort study.

Subjects And Setting: We reviewed medical records of 413 patients with a total of 522 CAPIs.

A multi-band high-sensitivity microwave sensor for simultaneous detection of two dielectric materials.

A multi-band high-sensitivity microwave sensor is reported. The two resonance units are based on complementary square spiral resonators (CSSRs) and produce four measurement bands through parasitic resonances. The four frequency bands are 2.

Robust Diagnosis of Acute Bacterial and Viral Infections via Host Gene Expression Rank-Based Ensemble Machine Learning Algorithm: A Multi-Cohort Model Development and Validation Study.

Background: The accurate and prompt diagnosis of infections is essential for improving patient outcomes and preventing bacterial drug resistance. Host gene expression profiling as an approach to infection diagnosis holds great potential in assisting early and accurate diagnosis of infection.

Methods: To improve the precision of infection diagnosis, we developed InfectDiagno, a rank-based ensemble machine learning algorithm for infection diagnosis via host gene expression patterns.

Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation.

Purpose: Immunometabolism is pivotal in rheumatoid arthritis (RA) pathogenesis, yet the intricacies of its pathological regulatory mechanisms remain poorly understood. This study explores the complex immunometabolic landscape of RA to identify potential therapeutic targets.

Patients And Methods: We integrated genome-wide association study (GWAS) data involving 1,400 plasma metabolites, 731 immune cell traits, and RA outcomes from over 58,000 participants.

Role of GLCCI1 in inhibiting PI3K-induced NLRP3 inflammasome activation in asthma.

Background: Glucocorticoid-induced transcript 1 (GLCCI1) has been reported to be associated with the efficiency of inhaled glucocorticoids in patients with asthma. This study aimed to investigate the role of GLCCI1 in the regulation of nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) by the phosphatidylinositol 3-kinase (PI3K) pathway in the pathogenesis of allergic asthma.

Methods: The expression levels of genes encoding GLCCI1, NLRP3 inflammasome components, and PI3K pathway-related indicators were detected in cells isolated from induced sputum from patients with asthma and healthy controls.

Marfan syndrome: insights from animal models.

Marfan syndrome (MFS) is an inherited disorder that affects the connective tissues and mainly presents in the bones, eyes, and cardiovascular system, etc. Aortic pathology is the leading cause of death in patients with Marfan syndrome. The fibrillin-1 gene () is a major gene involved in the pathogenesis of MFS.