Publications by authors named "Zhang'e Xiong"
SIRT3, a New Hope in Liver Diseases from Pathogenic Mechanisms to Therapeutic Strategies.
Curr Pharm Biotechnol
October 2024
The liver, the largest internal organ in the human body, regulates multiple reactions and processes, including detoxification, regeneration, and immune defense. Liver diseases have emerged as a significant global public health issue. Numerous studies have indicated that the mitochondrial deacetylase SIRT3 has played various roles in the pathogenesis and pathological progression of liver diseases.
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- NAD levels decrease with age, and supplementing with nicotinamide mononucleotide (NMN), a precursor to NAD, could potentially improve health and longevity in mice on a high-fat diet.
- Long-term NMN treatment resulted in increased NAD levels, reduced obesity, enhanced physical activity, and improved functions of skeletal muscle and kidneys, while also mitigating age-related inflammation.
- The study suggests NMN may protect against diet-induced damage by affecting the autophagic pathway and regulating autophagy levels in different tissues.
Article Synopsis
- Nicotinamide Mononucleotide (NMN) is being researched for its potential anti-aging benefits, particularly regarding muscle and liver functions in middle-aged and elderly people.
- A meta-analysis of randomized controlled trials evaluated the effects of NMN, finding significant improvements in muscle mass and liver enzyme levels among participants.
- The study concludes that NMN shows promise as an effective treatment to enhance muscle function, lower insulin resistance, and improve liver health in older adults.
Background: Rectal mucosal melanoma is a rare and highly aggressive disease. Common symptoms include anal pain, an anal mass, or bleeding. As such, the disease is usually detected on rectal examination of patients with other suspected anorectal diseases.
View Article and Find Full Text PDFObjective: To explore the effect of Ludangshen oral liquid for treatment of convalescent patients with coronavirus disease 2019 (COVID-19) with randomized, double-blind, placebo-controlled multicenter method.
Methods: 200 convalescent COVID-19 patients who had symptoms related to decreased digestive and respiratory function were randomly divided to either receive Ludangshen oral liquid or placebo for 2 weeks. The severity of clinical symptoms including fatigue, anorexia, abdominal distension, loose stools, and shortness of breath were assessed by visual analogue scale and observed at before and after treatment.
Background: Curcumin is a major active ingredient extracted from powdered dry rhizome of Curcuma longa. In Ayurveda and traditional Chinese medicine, it has been used as a hepatoprotective agent for centuries. However, the underlying mechanisms are not clear.
View Article and Find Full Text PDFObjective: This study aimed to investigate the protective effect of curcumin on chronic ethanol-induced liver injury in mice and to explore its underlying mechanisms.
Materials And Methods: Ethanol-exposed Balb/c mice were simultaneously treated with curcumin for 6 weeks. Liver injury was evaluated by biochemical and histopathological examination.