Gender and Age Differences in Corpus Callosum Morphology: High-Altitude Adaptations in Native Tibetan Populations.

Background And Aims: The corpus callosum is recognized as the largest interhemispheric white matter structure, coordinating distinct functions of the brain. High-altitude environments may influence the structure of the corpus callosum. This study aims to evaluate the morphologic characteristics of the corpus callosum in Tibetans residing on the Qinghai-Tibet Plateau while investigating the effects of sex, age, and high-altitude exposure on its morphology.

Alveolar macrophages from septic mice promote polymorphonuclear leukocyte transendothelial migration via an endothelial cell Src kinase/NADPH oxidase pathway.

Alveolar macrophages (AMphi) have been implicated in the polymorphonuclear leukocyte (PMN) recruitment to the lungs during sepsis. Using an in vivo murine model of sepsis (feces in the peritoneum), we show that peritonitis leads to increased activation of AMphi and PMN migration into pulmonary alveoli. To assess cellular mechanisms, an in vitro construct of the pulmonary vascular-interstitial interface (murine AMphi, pulmonary endothelial cells, and PMN) and a chimera approach were used.