LncRNA SNHG11 promotes the malignant transformation of human bronchial epithelial cells induced by beryllium sulfate.

Background: Beryllium and its compounds are carcinogenicity, but the mechanisms through which this occurs have yet to be clarified. Accumulating evidence exists that long noncoding RNAs (lncRNAs) play an important role in occurrence and development of cancer.

Aims And Methods: To explore the carcinogenic mechanism of beryllium, human bronchial epithelial cells (16HBE) were treated with 50 μM beryllium sulfate (BeSO) for 45 passages (~23 weeks).

METTL3 plays a crucial function in multiple biological processes.

The N6-methyladenosine (mA) refers to the methylation of the N6 position of adenosine of RNA adenine. The modification of mA is one of the most abundant epigenetic modifications in eukaryotic mRNA and non-coding RNA and is controlled by methyltransferases and demethylases. The biological mechanism and significance of mA have been discovered with the development of mA sequencing.

Whole transcriptome analysis of long noncoding RNA in beryllium sulfate-treated 16HBE cells.

Beryllium and its compounds can cause pulmonary interstitial fibrosis through mechanisms that are not yet clear. Long non-coding RNA (lncRNA) is implicated in various diseases. The molecular toxicity of beryllium sulfate (BeSO) was investigated through the RNA-seq analysis of the lncRNA and mRNA whole-transcriptome of BeSO-treated 16HBE cells.

Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats.

Context: Ellagic acid (EA) is a phenolic constituent in certain fruits and has largely been recognized for its role as an antioxidant compound.

Objective: To evaluate the effect of EA on beryllium sulphate-induced splenic toxicity in rats.

Materials And Methods: Male Sprague-Dawley rats were divided into four groups.

Serum-derived exosomes from SD rats induce inflammation in macrophages through the mTOR pathway.

Inhalation of beryllium and its compounds can cause lung injuries, resulting from inflammation and oxidative stress. Multivesicular bodies (MVB), such as exosomes, are membrane vesicles produced by early and late endosomes that mediate intercellular communications. However, the role of exosomes in beryllium toxicity has not been elucidated.

Proteomic characteristics of beryllium sulfate-induced differentially expressed proteins in rats.

Sprague Dawley rats were exposed to beryllium sulfate (BeSO), and proteomic and bioinformatic techniques were applied to screen for differentially expressed proteins in their lung tissue and serum. A total of 12 coexpression modules were constructed for 18 samples with 2333 proteins. Four modules were found to have significant differences in the regulation of protein coexpression modules in the serum following exposure to BeSO.

Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.

Beryllium and its compounds are systemic toxicants that are widely applied in many industries. Hydrogen sulfide has been found to protect cells. The present study aimed to determine the protective mechanisms involved in hydrogen sulfide treatment of 16HBE cells following beryllium sulfate-induced injury.