Publications by authors named "Zhanar Akhmetova"
Objective: The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on the development of rheumatoid arthritis.
Methods: This study was performed in Astana, Kazakhstan, and included 77 Kazakh female patients older than 18 years, who met the American College of Rheumatology 2010 classification criteria for rheumatoid arthritis (RA), and 113 healthy controls. The DNA was extracted from fecal samples obtained from all study participants for subsequent sequencing at the 16S rRNA gene V1-V3 locus, facilitating the analysis of the gut microbiome.
This study aimed to identify the oral microbial signature of Kazakh female rheumatoid arthritis (RA) patients. A total of 75 female patients who met the American College of Rheumatology 2010 classification criteria for RA and 114 healthy volunteers were included in the study. Amplicons of the 16S rRNA gene were sequenced to analyze the microbial composition.
View Article and Find Full Text PDFIntroduction: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology that leads to disability due to articular and extra-articular damage. RA prevalence is variable. The disease is most common among females with a 3 : 1 ratio.
View Article and Find Full Text PDFDeleterious effect of cold on overall mortality is well-established. We studied associations between the air temperature and the number f ambulance calls for asthma in Nur-Sultan, Kazakhstan - the second coldest capital in the world. Daily counts of ambulance calls for asthma in Nur-Sultan for the cold seasons (October-March) 2006-2010 were obtained from the Municipal Ambulance Station.
View Article and Find Full Text PDFCost-effectiveness of Oral Protease Inhibitors Co-administration versus Pegylated Interferon-Α2b and Ribavirin Only for the Patients with Hepatitis C Genotype 1 in Kazakhstan Health Care Settings.
Iran J Public Health
December 2018
Article Synopsis
- The study compares the effectiveness and cost-effectiveness of a triple therapy (peginterferon, ribavirin, and protease inhibitors) against a dual therapy (peginterferon and ribavirin) for treating chronic HCV in Kazakhstan.
- A Markov model was utilized to evaluate long-term outcomes and costs, revealing that patients on triple therapy had better health outcomes and quality-adjusted life years (QALYs) than those on standard treatment.
- The findings suggest that adding protease inhibitors to the standard treatment is cost-effective, with cost per QALY falling within acceptable thresholds based on Kazakhstan's economic standards.