Predictive accuracy of machine learning for radiation-induced temporal lobe injury in nasopharyngeal carcinoma patients: a systematic review and meta-analysis.

Background: Radiotherapy is a common treatment for nasopharyngeal carcinoma (NPC) but can cause radiation-induced temporal lobe injury (RTLI), resulting in irreversible damage. Predicting RTLI at the early stage may help with that issue by personalized adjustment of radiation dose based on the predicted risk. Machine learning (ML) models have recently been used to predict RTLI but their predictive accuracy remains unclear because the reported concordance index (C-index) varied widely from around 0.

Qualification of Pilots with Aero-Otitis Media After Balloon Eustachian Tuboplasty.

Aero-otitis media (AOM), also known as aural barotrauma or barotitis media, is categorized into primary AOM and secondary AOM. Because conservative treatment was ineffective, primary AOM was one of the main reasons for grounding. In 2014, the team successfully treated a pilot with primary AOM using balloon Eustachian tuboplasty (BET).

The effect of vascular risk factors on the efficacy of endolymphatic sac decompression surgery for Meniere's disease: a retrospective cohort study.

Objectives: This study aimed to investigate the effect of vascular risk factors on the outcomes of endolymphatic sac decompression (ESD) surgery in patients with Meniere's disease.

Methods: The study included 56 patients with Meniere's disease, who had undergone unilateral ESD surgery. The patients' vascular risk factors were assessed based on the preoperative 10-year atherosclerotic cardiovascular diseases risk classification.

Pilots' Spatial Visualization Ability Assessment Based on Virtual Reality.

The aim of this study was to investigate the effectiveness of the mental rotation test (MRT) based on virtual reality (VR) in predicting pilots' spatial visualization ability (SVA). Based on VR, 118 healthy pilots' SVA were evaluated by MRT. The pilot flight ability evaluation scale was used as the criterion of test validity.

Identification of a novel DFNA5 mutation, IVS7-2 a > G, in a Chinese family with non-syndromic sensorineural hearing loss.

Background: To date, seven mutations have been reported in families with autosomal dominant non-syndromic hearing loss worldwide. All the mutations cause exon 8 skipping at the mRNA level, that led to the protein truncated and the protein could exert a gain of ototoxic function.

Objective: In this study, we found an autosomal-dominant non-syndromic hearing loss Chinese pedigree which spanned four generations and comprised 43 members.

[Comparative study on the clinical features of familial clustered and sporadic vestibular migraine].

To compare and analyze the clinical features of family clustered vestibular migraine（FCVM） and sporadic vestibular migraine（SVM）. A total of 118 patients with vestibular migraine were selected and divided into FCVM group（66 cases） and SVM group（52 cases）, and the clinical features such as age, the form of symptoms, provoking and relieving factors, audiological manifestations, sequelae and complications, were compared and analyzed. The onset of headache in FCVM group was earlier than that in SVM group （[23.

Carotid imaging changes and serum IL-1β, sICAM-1, and sVAP-1 levels in benign paroxysmal positional vertigo.

Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo. This study was performed to evaluate serum levels of inflammatory factors and changes in B-mode carotid ultrasound findings in patients with BPPV. The study population consisted of 90 BPPV patients and 90 age- and sex-matched controls.

[Analysis of clinical features of vestibular migraine].

To analyze the clinical features of Vestibular migraine（VM） and provide evidence for its accurate diagnosis and medical identification of flight personnel. A total of 490 samples of VM patients were collected. Among them, 88 samples were secondary to benign paroxysmal positional vertigo（BPPV）, and 11 samples were co-occurring with Meniere's disease（MD）.

Dynamic Rabbit Model of Ear Barotrauma.

Establishing animal models of ear barotrauma (EB) to provide evaluation criteria for Eustachian tube dysfunction. Using expansive sponges, 70 rabbits' right pharyngeal openings of the auditory tubes were blocked to cause dysfunction in the right Eustachian tubes. The right tympanic cavities of 65 rabbits were the Model Group (Subgroups 1-13) and these rabbits' left tympanic cavities were the Nonblockage Group.

The epigenetically-regulated miR-34a targeting c-SRC suppresses RAF/MEK/ERK signaling pathway in K-562 cells.

Previous reports show that miR-34a suppressed K-562 cell proliferation and contributed to megakaryocytic differentiation of K-562 cells. Here, we reported that miR-34a, a tumor suppressor gene, is down-regulated in the K-562 cells and chronic myeloid leukemia (CML) patients due to aberrant DNA hypermethylation. c-SRC is a target of miR-34a.

A Dynamic Rabbit Model of Sinus Barotrauma and Its Related Pathology.

Background: This study was undertaken to establish a dynamic animal model of sinus barotrauma (SB).

Methods: The right nasal cavities of 65 rabbits were filled with sponges to obstruct the right ostiomeatal complex (OMC), while in the left nasal cavities, the left OMC was kept clear. The rabbits were exposed to hypobaric chamber simulation.

Variants in the KCNE1 or KCNE3 gene and risk of Ménière's disease: A meta-analysis.

Background: Ménière's disease (MD) is defined as an idiopathic disorder of the inner ear characterized by the triad of tinnitus, vertigo, and sensorineural hearing loss. Although many studies have evaluated the association between variants in the KCNE1 or KCNE3 gene and MD risk, debates still exist.

Objective: Our aim is to evaluate the association between KCNE gene variants, including KCNE1 rs1805127 and KCNE3 rs2270676, and the risk of MD by a systematic review.

Radiotherapeutic treatment of a fighter pilot with nasopharyngeal carcinoma.

Background: Radiotherapy is the standard and most effective treatment for nasopharyngeal carcinoma (NPC) in its early stages. However, its application in fighter pilots returning to flying duties with NPC has not been previously reported, presumably due to post-radiotherapeutic complications.

Case Report: A 36-yr-old male fighter pilot had a painless mass in the left neck for 5 mo.

Resolving the genetic heterogeneity of prelingual hearing loss within one family: Performance comparison and application of two targeted next generation sequencing approaches.

Here, we report an unconventional Chinese pedigree consisting of three branches all segregating prelingual hearing loss (HL) with unclear inheritance pattern. After identifying the cause of one branch as maternally inherited aminoglycoside-induced HL, targeted next generation sequencing (NGS) was applied to identify the genetic causes for the other two branches. One affected subject from each branch was subject to targeted NGS whose genomic DNA was enriched either by whole-exome capture (Agilent SureSelect All Exon 50 Mb) or by candidate genes capture (Agilent SureSelect custom kit).

Preimplantation genetic diagnosis for a Chinese family with autosomal recessive Meckel-Gruber syndrome type 3 (MKS3).

Meckel-Gruber syndrome type 3 is an autosomal recessive genetic defect caused by mutations in TMEM67 gene. In our previous study, we have identified a homozygous TMEM67 mutation in a Chinese family exhibiting clinical characteristics of MKS3, which provided a ground for further PGD procedure. Here we report the development and the first clinical application of the PGD for this MKS3 family.

Identification of a Novel TECTA mutation in a Chinese DFNA8/12 family with prelingual progressive sensorineural hearing impairment.

Tectorial membrane, an extracellular matrix of the cochlea, plays a crucial role in the transmission of sound to the sensory hair cells. Alpha-tectorin is the most important noncollagenous component of the tectorial membrane and the otolith membrane in the maculae of the vestibular system. Defects in TECTA, the gene encodes alpha-tectorin, are cause of both dominant (DFNA8/12) and recessive (DFNB21) forms of deafness.

[Characteristics of audiology and clinical genetics of a Chinese family with the DFNA5 genetic hearing loss].

Objective: To analysis the characteristics of audiology and clinical genetics of a Chinese family with the DFNA5 genetic hearing loss in detail.

Method: A detailed family history and clinical data were collected. The Chinese pedigree is an autosomal-dominant inherited hearing loss.

[Diagnosis, treatment and medical evaluation of head and neck tumors in aircrew].

Objective: To sum up the experiences of diagnosis, treatment and medical evaluation of head and neck tumors in aircrew.

Method: Sixty-seven cases of pilot patients with head and neck tumors in our hospital since September in 1979 to July in 2009 were retrospective analyzed in the study.

Result: Among 44 aircrew with benign head and neck tumors there were 37 cases continued their flying jobs and 7 cases were permanently grounded; whereas in 23 aircrew with malignant tumors there were 6 cases qualified for flight and 17 patients unqualified.

[Genetic and audiological characters of a Chinese family with non-syndromic hereditary hearing loss].

Objective: To investigate the phenotype and genetic characters of a Chinese family with an autosomal-dominant inherited high-frequency sensorineural hearing loss.

Method: A Chinese pedigree associated with an autosomal-dominant inherited high-frequency sensorineural hearing loss was investigated. After obtaining informed consent from all study participants medical and audiological examination to rule out any syndromic hearing impairment.

Identification of two novel missense WFS1 mutations, H696Y and R703H, in patients with non-syndromic low-frequency sensorineural hearing loss.

Non-syndromic low-frequency sensorineural hearing loss (LFSNHL) is an unusual type of hearing loss in which frequencies ≤2000 Hz predominantly are affected. To date, different mutations in two genes, DIAPH1 and WFS1, have been found to be associated with LFSNHL. Here, we report a five-generation Chinese family with postlingual and progressive LFSNHL.

Novel missense mutations in MYO7A underlying postlingual high- or low-frequency non-syndromic hearing impairment in two large families from China.

The myosin VIIA (MYO7A) gene encodes a protein classified as an unconventional myosin. Mutations within MYO7A can lead to both syndromic and non-syndromic hearing impairment in humans. Among different mutations reported in MYO7A, only five led to non-syndromic sensorineural deafness autosomal dominant type 11 (DFNA11).

[Preliminary study on diplopore puncture of tympanum and intratympanic administration for management of acute secretory otitis media].

Objective: To evaluate the therapeutical effects of diplopore puncture of tympanum and intratympanic administration (DPTIA) on patients with acute secretory otitis media (ASOM).

Method: One hundred and forty-one cases with ASOM were divided into two groups randomly, with 69 cases (80 ears) in group A (experimental group) and 72 cases (84 ears) in group B (control group). Group A was treated with DPTIA combined with medication, group B was treated with haplopore puncture of tympanum combined with medication.