Publications by authors named "Zhan-Zhong Ma"
Objectives: Shaokwan is one of the inhabitant regions of Hakka population in Guangdong province of southern China. Previous survey has reported that a higher prevalence of abnormal hemoglobin (Hb) in this region. However, large-scale survey on the molecular characteristics of abnormal hemoglobin in this south-north junctional region has not been reported.
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- Bisalbuminemia is a hereditary or acquired condition marked by an abnormal double albumin band in blood tests, but there has been limited research on its variants in Chinese populations.
- A study involving 71,963 subjects from southern China used electrophoresis and DNA sequencing to identify ALB variants, revealing an incidence of 0.0264% for inherited bisalbuminemia.
- Four specific ALB variants were discovered, with a significantly higher frequency found in the Wuxi region, especially for proalbumin Lille, highlighting regional differences in prevalence and mutation patterns.
[Selecting and affinity analysis of DNA aptamers to MPT64 protein from Mycobacterium tuberculosis].
Zhonghua Jie He He Hu Xi Za Zhi
June 2008
Objective: To obtain DNA oligonucleotide aptamers which can specifically bind to MPT64 protein from Mycobacterium tuberculosis by SELEX technology.
Methods: An in vitro synthesized 78 per random DNA library was subjected to 12 rounds of selection by SELEX (Systematic evolution of ligands by exponential enrichment) method against MPT64 protein. Binding of the aptamers to the protein was examined by biotin-streptavidin-horseradish peroxidase system.