Publications by authors named "Zhan-Yin Dong"
Intervertebral disc degeneration (IDD) is the most common degenerative disease all over the word. Our previous study confirmed that the downregulated circ-GRB10 directly interacts with miR-328-5p, which modulate ERBB2 and leads to the degeneration of intervertebral disc; however, the underpinning mechanism of circ-GRB10 dysregulation remains unclear. We identified that FUS and demonstrated that circ-GBR10 biosynthesis in nucleus pulposus (NP) cells was promoted by FUS, whose expression was controlled by miR-141-3p.
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- Intervertebral disc degeneration (IDD) is a key cause of lower back pain, and this study explores the role of a circular RNA (circ-TIMP2) in the degeneration of nucleus pulposus (NP) tissues.
- The research found that overexpressing miR-185-5p in NP cells reduced the catabolism of the extracellular matrix (ECM) triggered by inflammatory factors TNF-α and IL-1β, with MMP2 identified as a target.
- The study concludes that circ-TIMP2 may worsen ECM degradation during IDD by binding to miR-185-5p, thus affecting ECM balance, which could open up new treatment avenues for IDD.
Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, although the underlying mechanisms remain poorly understood. In this study we examined the role of circular RNA FAM169A (circ-FAM169A) in degenerative nucleus pulposus (NP) tissues, and validated its function in cultured human NP cells. Overexpression of circ-FAM169A in NP cells markedly enhanced extracellular matrix (ECM) catabolism and suppressed ECM anabolism in NP cells.
View Article and Find Full Text PDFIntervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis.
View Article and Find Full Text PDFStudy Design: A microRNA (miRNA) study.
Objective: The purpose of this study was to identify intervertebral disc degeneration (IDD)-specific miRNAs, followed by functional validation of results.
Summary Of Background Data: IDD is the major contributor to back radicular pain, and the molecular mechanisms underlying this disease are not completely understood.