Glycosylation gene expression profiles enable prognosis prediction for colorectal cancer.

This study developed a prognostic model for patients with colon adenocarcinoma (COAD) based on glycosylation-associated genes. By analyzing TCGA-COAD data, 110 key genes were identified, and a prognostic model incorporating five glycosylation-related genes was constructed. The model exhibits good predictive performance and is significantly associated with clinical features such as age, N stage, M stage, and lymph node count.

Excellent thermoelectric performance in alkali metal phosphides MP (M = Na and K) with phonon-glass electron-crystal like behaviour.

Identifying ideal thermoelectric materials presents a formidable challenge due to the intricate coupling relationship between thermal conductivity and power factor. Here, based on first-principles calculations, along with self-consistent phonon theory and the Boltzmann transport equation, we theoretically investigate the thermoelectric properties of alkali metal phosphides MP (M = Na and K). The evident 'avoided crossing' phenomenon indicates the phonon glass behavior of MP (M = Na and K).

The synthesis of triacylglycerol by diacylglycerol acyltransferases (CsDGAT1A and CsDGAT2D) is essential for tolerance of cucumber's resistance to low-temperature stress.

CsDGAT1A and CsDGAT2D play a positive regulatory role in cucumber's response to low-temperature stress and positively regulate the synthesis of triacylglycerol (TAG). Triacylglycerol (TAG), a highly abundant and significant organic compound in plants, plays crucial roles in plant growth, development, and stress responses. The final acetylation step of TAG synthesis is catalyzed by diacylglycerol acyltransferases (DGATs).

Perianal fistulizing lesions of Crohn's disease are associated with long-term behavior and its transition: a Chinese cohort study.

Background/aims: Crohn's disease (CD) has a progressive nature and commonly perianal involvement. The aim of this study is to assess the prevalence, surgical treatment, and outcome of perianal fistulizing CD with associated risk factors in a large Chinese cohort.

Methods: Hospitalized patients diagnosed with CD in our center were consecutively enrolled between January 2000 and December 2018.

Comparison between Endoscopic Ultrasound-Guided Antegrade and Transluminal Stent Implantation in Distal Malignant Biliary Obstruction after Failed ERCP.

Background: Distal malignant biliary obstruction (DMBO) can result in obstructive jaundice. Endoscopic ultrasound- (EUS-) guided biliary drainage (EUS-BD) has been an alternative for DMBO after failed ERCP.

Aim: To compare the efficacy and safety between antegrade and transluminal approaches in patients with unresectable DMBO when ERCP failed.

Accurate object localization facilitates automatic esophagus segmentation in deep learning.

Background: Currently, automatic esophagus segmentation remains a challenging task due to its small size, low contrast, and large shape variation. We aimed to improve the performance of esophagus segmentation in deep learning by applying a strategy that involves locating the object first and then performing the segmentation task.

Methods: A total of 100 cases with thoracic computed tomography scans from two publicly available datasets were used in this study.

Sodium citrate targeting Ca/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.

Introduction: Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear.

Objectives: To analyze the inhibitory effect of sodium citrate on ovarian cancer cells and the underlying mechanism.

Activating peroxymonosulfate with Fe-doped biochar for efficient removal of tetracycline: Dual action of reactive oxygen species and electron transfer.

If pharmaceutical wastewater is not managed effectively, the presence of residual antibiotics will result in significant environmental contamination. In addition, inadequate utilization of agricultural waste represents a squandering of resources. The objective of this research was to assess the efficacy of iron-doped biochar (Fe-BC) derived from peanut shells in degrading high concentrations of Tetracycline (TC) wastewater through activated peroxymonosulfate.

Adeno-associated virus as a delivery vector for gene therapy of human diseases.

Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues. Recombinant AAV (rAAV) has been engineered for enhanced specificity and developed as a tool for treating various diseases. However, as rAAV is being more widely used as a therapy, the increased demand has created challenges for the existing manufacturing methods.

Mesoporous carbon nanoparticles embedded with iron in hydrogen-photothermal synergistic therapy.

We developed a new method to synthesize polyethylene glycol modified ultra small iron embedded in mesoporous carbon nanoparticle (C/Fe-PEG NP) for hydrogen (H) assisted photothermal synergistic therapy. Herein, we use a simple in-situ reduction method to obtain the C/Fe NP in one-step carbonizing process, which is further modified by the biocompatible polyethylene glycol (PEG) on the surface of C/Fe NP to acquire high stability in physiological solutions. Utilizing the excellent photothermal property from the mesoporous carbon and the controllable H release property in the weakly acidic tumor microenvironment by the ultra-small Fe, the obtained C/Fe-PEG NPs can effective kill the cancer cells, meanwhile, protect normal cells without drugs.

Bioinformatics analysis of markers based on m6A related to prognosis combined with immune invasion of rectal adenocarcinoma.

Background: Colorectal cancer (CRC) is a common form of cancer, with rectal cancer accounting for approximately one-third of all cases. Among rectal cancers, 95% are classified as rectal adenocarcinoma (READ). Emerging evidence suggests that long noncoding RNAs (lncRNAs) play a significant role in the development and progression of various cancers.

The light and hypoxia induced gene ZmPORB1 determines tocopherol content in the maize kernel.

Tocopherol is an important lipid-soluble antioxidant beneficial for both human health and plant growth. Here, we fine mapped a major QTL-qVE1 affecting γ-tocopherol content in maize kernel, positionally cloned and confirmed the underlying gene ZmPORB1 (por1), as a protochlorophyllide oxidoreductase. A 13.

A series of methods incorporating deep learning and computer vision techniques in the study of fruit fly (Diptera: Tephritidae) regurgitation.

In this study, we explored the potential of fruit fly regurgitation as a window to understand complex behaviors, such as predation and defense mechanisms, with implications for species-specific control measures that can enhance fruit quality and yield. We leverage deep learning and computer vision technologies to propose three distinct methodologies that advance the recognition, extraction, and trajectory tracking of fruit fly regurgitation. These methods show promise for broader applications in insect behavioral studies.

Telomere-to-telomere and gap-free genome assembly of a susceptible grapevine species (Thompson Seedless) to facilitate grape functional genomics.

Grapes are globally recognized as economically significant fruit trees. Among grape varieties, Thompson Seedless holds paramount influence for fresh consumption and for extensive applications in winemaking, drying, and juicing. This variety is one of the most efficient genotypes for grape genetic modification.

Decoding China's anthropogenic typical pollutant discharge patterns: Long-term dynamics and hotspot transitions driven by population, diet, and sanitation.

Human activities have led to an alarming increase in pollution, resulting in widespread water contamination. A comprehensive understanding of the quantitative relationship between anthropogenic pollutant discharges and the escalating anthropogenic disturbances and environmental efforts is crucial for effective water quality management. Here we establish a Model for Estimating Anthropogenic pollutaNts diScharges (MEANS) and simulate the long-term dynamics of various types of anthropogenic discharges in China based on an unprecedented spatio-temporal dynamic parameter dataset.

Efficient Carrier Transport in 2D BiOSe/CsBiI Perovskite Heterojunction Enables Highly-Sensitive Broadband Photodetection.

2D BiOSe has recently garnered significant attention in the electronics and optoelectronics fields due to its remarkable photosensitivity, broad spectral absorption, and excellent long-term environmental stability. However, the development of integrated BiOSe photodetector with high performance and low-power consumption is limited by material synthesis method and the inherent high carrier concentration of BiOSe. Here, a type-I heterojunction is presented, comprising 2D BiOSe and lead-free bismuth perovskite CsBiI, for fast response and broadband detection.

Remarkable adsorption of As(V) by Fe and Mg modified alginate porous beads (Fe/Mg-SA) via a facile method.

Although sodium alginate (SA) is frequently utilized because of its good gelling properties, the substance's dearth of adsorption active sites prevents it from effectively removing heavy metals. Herein, SA was used as the base material to form a cross-linked structure with Fe and Mg, and gel beads with a diameter of 2.0 ± 0.

Estimating Yangtze River basin's riverine NO emissions through hybrid modeling of land-river-atmosphere nitrogen flows.

Riverine ecosystems are a significant source of nitrous oxide (NO) worldwide, but how they respond to human and natural changes remains unknown. In this study, we developed a compound model chain that integrates mechanism-based modeling and machine learning to understand NO transfer patterns within land, rivers, and the atmosphere. The findings reveal a decrease in NO emissions in the Yangtze River basin from 4.

Machine learning parallel system for integrated process-model calibration and accuracy enhancement in sewer-river system.

The process-based water system models have been transitioning from single-functional to integrated multi-objective and multi-functional since the worldwide digital upgrade of urban water system management. The proliferation of model complexity results in more significant uncertainty and computational requirements. However, conventional model calibration methods are insufficient in dealing with extensive computational time and limited monitoring samples.

Removal of sulfonamide antibiotics by a sonocatalytic Fenton-like reaction: Efficiency and mechanisms.

With the widespread use of sulfonamide antibiotics (SAs), SAs are detected as residues in aquatic environments, posing a serious threat to human life and safety. Because of their high water solubility, fast transmission rate, and strong antibacterial properties, the safe disposal of SAs has become a key constraint for water quality assurance. Therefore, an ultrasound (US)-assisted zero-valent iron (ZVI)/persulfate (PS) system was proposed to explore the rapid and effective degradation of SAs.

Unraveling spatial patterns and source attribution of nutrient transport: Towards optimal best management practices in complex river basin.

A comprehensive understanding of nutrient transport patterns and clarification of pollutant sources' load contributions are critical prerequisites for developing scientific pollution control strategies in complex river basins. Here, we focused on the Minjiang River Basin (MRB) and employed the Soil and Water Assessment Tool (SWAT) model to systematically investigate the nitrogen (N) and phosphorus (P) loads from both point and non-point sources. Results revealed that the key source areas of N and P pollution in the MRB were predominantly located along the riverbanks, influenced by a combination of sediment, precipitation, agricultural activities such as fertilization.

Hsa_circRNA_102051 regulates colorectal cancer proliferation and metastasis by mediating Notch pathway.

Background: The purpose of this study was to investigate the role of hsa_circRNA_102051 in colorectal cancer (CRC) and its effect on the stemness of tumor cells.

Methods: CircRNA microarray was under analysis to screen differentially expressed novel circRNAs in the pathology of CRC. Quantitative real-time PCR was used to detect the relative RNA expression in CRC cells and samples.