Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axis.

Cancer cells with RAS mutations exhibit enhanced autophagy, essential for their proliferation and survival, making it a potential target for therapeutic intervention. However, the regulatory differences between RAS-induced autophagy and physiological autophagy remain poorly understood, complicating the development of cancer-specific anti-autophagy treatments. In this study, we identified a form of non-canonical autophagy induced by oncogenic KRAS expression, termed RAS-induced non-canonical autophagy via ATG8ylation (RINCAA).

NEAT-Net: An Unsupervised Cross-View Prior Inpainting Network for CBCT Metal Artifact Reduction.

Intraoperative Cone-Beam Computed Tomography (CBCT) facilitates intraoperative navigation for Minimally Invasive Spine Surgery (MISS). However, high-attenuation metal implants used in MISS often cause metal artifacts in the reconstructed CBCT images. Current algorithms do not consider the cross-view information in the projection-domain for metal artifact reduction (MAR).

Implications of oral streptococcal bacteriophages in autism spectrum disorder.

Growing evidence suggests altered oral and gut microbiota in autism spectrum disorder (ASD), but little is known about the alterations and roles of phages, especially within the oral microbiota in ASD subjects. We enrolled ASD (n = 26) and neurotypical subjects (n = 26) with their oral hygiene controlled, and the metagenomes of both oral and fecal samples (n = 104) are shotgun-sequenced and compared. We observe extensive and diverse oral phageome comparable to that of the gut, and clear signals of mouth-to-gut phage strain transfer within individuals.

Quantitative reconstruction of the complex-valued object based on complementary phase modulations.

In the coherent diffraction imaging (CDI) techniques, a key point is to reconstruct the complex-valued object from the far-field intensity measurements, i.e., solving the phase retrieval problem.

Identification and Functional Analysis of Long Non-coding RNAs in Autism Spectrum Disorders.

Genetic and environmental factors, alone or in combination, contribute to the pathogenesis of autism spectrum disorder (ASD). Although many protein-coding genes have now been identified as disease risk genes for ASD, a detailed illustration of long non-coding RNAs (lncRNAs) associated with ASD remains elusive. In this study, we first identified ASD-related lncRNAs based on genomic variant data of individuals with ASD from a twin study.

Identifying potential drug targets in hepatocellular carcinoma based on network analysis and one-class support vector machine.

Hepatocellular carcinoma (HCC) is one major cause of cancer-related death worldwide. But now, the systematic therapy for the advanced stages of HCC is rather limited. Thus, the discovery of novel drug targets and thereafter targeted drugs against HCC is continuously needed.

Selective oxidation of glycerol to tartronic acid over Pt/N-doped mesoporous carbon with extra framework magnesium catalysts under base-free conditions.

N-Doped mesoporous carbons (NMCs) with extra framework magnesium were prepared by a one-pot method and used as supports for Pt catalysts. The surface basicity of NMC improved in the presence of extra framework magnesium (e.g.

TransmiR v2.0: an updated transcription factor-microRNA regulation database.

MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and play vital roles in various biological processes. It has been reported that aberrant regulation of miRNAs was associated with the development and progression of various diseases, but the underlying mechanisms are not fully deciphered. Here, we described our updated TransmiR v2.

Production of cellulase by from pretreated straw and furfural residues.

In this study, furfural residues were used as a substrate for cellulase production by the fungi . The results indicated that a low pH and the presence of lignin in the furfural residues have an obvious impact on cellulase production by . After pH adjustment, furfural residues could be used for cellulase production by , with a higher filter paper activity (FPA) and a higher activity of CMCase compared to that yielded from furfural residues with pH unadjusted.

Osmotically driven membrane process for the management of urban runoff in coastal regions.

An osmotic detention pond was proposed for the management of urban runoff in coastal regions. Forward osmosis was employed as a bridge to utilize natural osmotic energy from seawater for concentrating and reusing urban runoff water, and as a barrier to reject runoff-derived contaminants. The process was demonstrated by a lab scale testing using synthetic urban runoff (as the feed solution) and synthetic seawater (as the draw solution).

Flux patterns and membrane fouling propensity during desalination of seawater by forward osmosis.

The membrane fouling propensity of natural seawater during forward osmosis was studied. Seawater from the Red Sea was used as the feed in a forward osmosis process while a 2M sodium chloride solution was used as the draw solution. The process was conducted in a semi-batch mode under two crossflow velocities, 16.

Direct functionalization of the hydroxyl group of the 6-mercapto-1-hexanol (MCH) ligand attached to gold nanoclusters.

Au-MCH nanoclusters of (1.5 +/- 0.3) nm diameter (MCH = 6-mercapto-1-hexanol, HS-(CH2)6-OH) have been prepared and characterized by Transmission Electron Microscopy (TEM), UV-visible, Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared (FTIR) absorption spectroscopies, X-ray Powder Diffraction (XRD), and Thermogravimetric Analysis (TGA).

[Influence of raising oxygen content on function of platelet concentrate during preservation].

To explore the influence of raising oxygen (dissolved oxygen) content on function of platelet concentrate, the platelet concentrate was prepared by a CS-3000 plus blood cell separator. Experiments were divided into 2 groups: test group and control group. After raising oxygen content in platelet plasma under sterile operation, the platelet samples of two groups were preserved in oscillator with horizontal oscillation at 22 +/- 2 degrees C.

Determination of nitrite in foods by single-sweep polarography.

In an acid medium, nitrite diazotized with p-rosaniline and then coupled with 8-hydroxyquinoline in a weak alkaline medium produces azo compounds. The azo compounds produce a very sensitive polarographic wave at -0.70 V (versus the saturated calomel electrode).