Handheld volumetric photoacoustic/ultrasound imaging using an internal scanning mechanism.

Photoacoustic/ultrasound (PA/US) dual-modality imaging has been evolving rapidly for the last two decades. Handheld PA/US probes with different implementations have attracted particular attention due to their convenience and high applicability. However, developing a volumetric dual-modality PA/US imaging probe with a compact design remains a challenge.

Multi-modality photoacoustic/ultrasound imaging based on a commercial ultrasound platform.

Multimodal imaging takes advantage of each modality and has become a recent trend in the field of biomedical imaging. In this Letter, we develop and evaluate an integrated multi-modality imaging system combining photoacoustic computed tomography, optical resolution photoacoustic microscopy, brightness mode, and power Doppler ultrasound imaging on a commercial ultrasonographic platform. Using different imaging modalities enables the hybrid system to recover dense vascular networks and hemodynamic and morphological variations in both superficial and deep tissues.

Dynamic pricing and inventory management with demand learning: A bayesian approach.

We consider a retail firm selling a durable product in a volatile market where the demand is price-sensitive and random but its distribution is unknown. The firm dynamically replenishes inventory and adjusts prices over time and learns about the demand distribution. Assuming that the demand model is of the multiplicative form and unmet demand is partially backlogged, we take the empirical Bayesian approach to formulate the problem as a stochastic dynamic program.

Pericyte-mediated vasoconstriction underlies TBI-induced hypoperfusion.

Objectives: Endothelin-1 is a 21-amino acid peptide that together with specific receptors, A (ETrA) and B (ETrB) is induced following traumatic brain injury (TBI) and has been closely linked to regulation of cerebral vasospasm, oxidative stress, and hypoperfusion. Specific endothelin receptor antagonists have been shown to ameliorate early evidence of neuronal cell injury, activation of microglial cells, and hypoperfusion following TBI. The exact mechanism involved in TBI-induced hypoperfusion is still unclear; however, it is thought that endothelin-1 engagement of ETrA is primarily responsible for changes in blood flow.