Discovery of marine ent-eudesmane sesquiterpenoids as angiogenic inhibitors via suppressing VEGF-A/VEGFR2 signaling pathway.

Increasing evidence underscores the pivotal role of tumor angiogenesis for tumorigenesis and tumor metastasis. Inhibiting the tumor angiogenesis process is a promising therapeutic approach for cancer. In order to search for natural angiogenic inhibitors, the chemical constitutes of a marine-derived fungus Eutypella sp.

Gender differences in the association between the uric acid to high-density lipoprotein cholesterol ratio and diabetes risk: a mediation analysis of c-reactive protein, triglycerides, and insulin resistance.

Background: The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel metabolic marker and is proven to be associated with diabetes risk. However, there is still a lack of systematic research regarding its role in gender differences and underlying mechanisms. This study aims to assess the association of UHR with diabetes risk in the context of gender differences and to investigate its mediation effects through metabolic and inflammatory pathways.

Enhanced Stretchable 2D Metal-Graphene Membranes with Superior Mechanical Properties for Sieving Lithium from Brine.

Designing mechanically robust, 2D membranes with elastic properties is crucial for advancing separation technologies, particularly in demanding environments such as saline lakes. Here, an innovative approach, the synthesis of silver nanosheets within graphene oxide (GO) membranes to form a 2D silver-graphene heterojunction, is introduced. This membrane exhibits exceptional mechanical strength (stress tolerance of 4.

Rationally designed Cas9 enables efficient gene activation and base editing.

Compact and adaptable CRISPR-Cas systems enable genome engineering applications in various contexts via high-efficiency delivery. The adeno-associated virus (AAV) is a widely used delivery system. One of the most compact type II-C Cas9 orthologs-CjCas9, derived from is particularly appealing for AAV delivery.

Perioperative Pain Observation of Hip Fracture Surgery Patients with Cheek Acupuncture.

Background: The objective of this study is to investigate the impact of cheek acupuncture on perioperative pain in patients with hip fracture.

Methods: A random number table was utilized to allocate the patients into three distinct cohorts: Only spinal anesthesia was performed (group S), cheek acupuncture was performed before spinal anesthesia (group C), and ultrasound-guided fascia iliaca block was performed before spinal anesthesia (group F). The primary outcome measure was the Visual Analogue Scale (VAS) score within 24 hours post-surgery, as well as the level of beta-endorphin.

Experimental and simulation study on compressive failure of rock with pre-Y-shaped cracks.

A large number of joints and fissures are prevalent in the rock mass, which has an important influence on the mechanical properties of the rock mass. To study the failure mechanical characteristics of Y-cracked rocks, the paper analyzes the influence of different angles of prefabricated Y-cracked rocks on the mechanical strength characteristics of the rocks and the crack extension evolution through uniaxial compression indoor tests and discrete element PFC2D numerical simulation. The results indicate that the stress-strain curves of rocks containing prefabricated cracks exhibit five stages: the initial pore-fracture compaction stage, the elastic stage, the crack stable development stage, the crack unstable development stage, and the post-peak rupture.

Layered Bio-Inorganic MXene Membranes: A Green Approach for Uranium Extraction from Seawater Using Genetically Modified .

With the growing demand for clean energy, efficient uranium extraction technologies are needed, especially from seawater, where uranium reserves are huge. Here, we developed a composite membrane by inserting engineered with super uranyl-binding protein (SUP) within a two-dimensional (2D) MXene (TiCT) layer. SUP endowed the bioinorganic hybrid membrane with ultrahigh selectivity for uranyl ions, while the engineered improved the mechanical strength and economy of the membranes.

A Nomogram for the Prediction of Invasiveness in Invasive Pulmonary Adenocarcinoma on the Basis of Multimodal PET/CT Parameters.

Objective: We investigated the value of PET/CT-based multimodal parameters in predicting the degree of differentiation and epidermal growth factor receptor (EGFR) mutations in invasive lung adenocarcinoma (ILA) and assessed the correlation between PET/CT-based multimodal parameters and Ki67.

Methods: We retrospectively collected 113 patients with ILA who underwent PET/CT examination, and differences in PET/CT multimodal parameters between different differentiation groups were analyzed. Binary logistic regression was used to establish a multiparameter model for predicting EGFR mutation, and ROC curve was used to compare the diagnostic efficiency.

2D Membranes Interlayered with Bimetallic Metal-Organic Frameworks for Lithium Separation from Brines.

Efficient lithium extraction from salt lakes is essential for a sustainable resource supply. This study tackles the challenge of separating Li from Mg in complex brines by innovatively integrating two-dimensional (2D) graphene oxide (GO) with bimetallic metal-organic frameworks (MOFs). Zn and Co ions are confined within GO interlayers through an in situ synthesis, forming a 2D Zn-Co MOFs/GO membrane (Zn-Co-GOM).

Diversity, Distribution and Structural Prediction of the Pathogenic Bacterial Effectors EspN and EspS.

Background: Many Gram-negative enterobacteria translocate virulence proteins (effectors) into intestinal epithelial cells using a type III secretion system (T3SS) to subvert the activity of various cell functions possess. Many T3SS effectors have been extensively characterized, but there are still some effector proteins whose functional information is completely unknown.

Methods: In this study, two predicted effectors of unknown function, EspN and EspS ( secreted protein N and S), were selected for analysis of translocation, distribution and structure prediction.

Coupling Disturbance Modeling and Compensation for Aerial Manipulator in Highly Dynamic Motion.

When a manipulator moves in a highly dynamic scenario with a large range of rapid motion, the coupling disturbances between the manipulator and the UAV in the aerial manipulator system (AMS) become very strong, which directly affects the ability of the AMS to perform aerial manipulation and even poses a threat to the safety of the system. The aim of this article is to address the strong coupling disturbance problem in the AMS through precise coupling disturbance modeling and compensation. First, considering the rapid changes in the center of mass (CoM) and the moment of inertia (MoI) of the system under a highly dynamic scenario, this article delves into the generation mechanism of the coupling disturbances and models them based on the variable inertia parameters.

Multiplexed quantum frequency conversion.

We study multiplexed quantum frequency conversion (m-QFC) on a single waveguide, where a single pump beam simultaneously converts multiple signal beams at distinct wavelengths. Using a three-peak periodically poled lithium niobate (PPLN) waveguide, we demonstrate the multiplexed upconversion in the telecom band with internal efficiencies up to 73.6.

PRN: progressive reasoning network and its image completion applications.

Ancient murals embody profound historical, cultural, scientific, and artistic values, yet many are afflicted with challenges such as pigment shedding or missing parts. While deep learning-based completion techniques have yielded remarkable results in restoring natural images, their application to damaged murals has been unsatisfactory due to data shifts and limited modeling efficacy. This paper proposes a novel progressive reasoning network designed specifically for mural image completion, inspired by the mural painting process.

Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single-Cell Level.

Heterotopic ossification (HO), often arising in response to traumatic challenges, results from the aberrant osteochondral differentiation of mesenchymal stem cells (MSCs). Nevertheless, the impact of trauma-induced inflammatory exposure on MSC fate determination remains ambiguous. In this study, the cellular diversity within inflammatory lesions is elucidated, comprising MSCs and several innate and adaptive immune cells.

Resolving tumor evolution: a phylogenetic approach.

The evolutionary dynamics of cancer, characterized by its profound heterogeneity, demand sophisticated tools for a holistic understanding. This review delves into tumor phylogenetics, an essential approach bridging evolutionary biology with oncology, offering unparalleled insights into cancer's evolutionary trajectory. We provide an overview of the workflow, encompassing study design, data acquisition, and phylogeny reconstruction.

Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis.

Joint pain and osteoarthritis can occur as coronavirus disease 2019 (COVID-19) sequelae after infection. However, little is known about the damage to articular cartilage. Here we illustrate knee joint damage after wild-type, Delta and Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vivo.

Fine-Tuning 2D Heterogeneous Channels for Charge-Lock Enhanced Lithium Separation from Brine.

The extraction of lithium (Li) from complex brines presents significant challenges due to the interference of competing ions, particularly magnesium (Mg⁺), which complicates the selective separation process. Herein, a strategy is introduced employing charge-lock enhanced 2D heterogeneous channels for the rapid and selective uptake of Li⁺. This approach integrates porous ZnFeO/ZnO nanosheets into Ag-modulated sub-nanometer interlayer channels, forming channels optimized for Li⁺ extraction.

Label-Free Microfluidic Apheresis of Circulating Tumor Cell Clusters.

Screening liters of blood (i.e., apheresis) represents a generalized approach to promote the reliable access to circulating tumor cell clusters (CTCCs), which are known to be highly metastasis-competent, yet ultrarare.

Corrigendum to: B2M is a Biomarker Associated With Immune Infiltration In High Altitude Pulmonary Edema.

The funding details have been incorporated upon author's request in the funding section of this article titled "B2M is a Biomarker Associated With Immune Infiltration In High Altitude Pulmonary Edema ," 2024, 27(1), 168-185 [1]. Details of the error and a correction are provided here. Original: This work was supported by grants from the Chongqing Natural Science Gene General Project (No.