Publications by authors named "Zhan'ao Meng"
To construct a urine extracellular vesicle long non-coding RNA (lncRNA) classifier that can detect high-grade prostate cancer (PCa) of grade group 2 or greater and estimate the risk of progression during active surveillance, we identify high-grade PCa-specific lncRNAs by combined analyses of cohorts from TAHSY, TCGA, and the GEO database. We develop and validate a 3-lncRNA diagnostic model (C, being made of AC015987.1, CTD-2589M5.
View Article and Find Full Text PDFBackground: We aimed to develop and validate a plasma extracellular vesicle circular RNA (circRNA)-based signature that can predict overall survival (OS) in first-line abiraterone therapy for metastatic castration-resistant prostate cancer (mCRPC) patients.
Methods: In total, 582 mCRPC patients undergoing first-line abiraterone therapy from four institutions were sorted by three phases. In the discovery phase, 30 plasma samples from 30 case-matched patients with or without early progression were obtained to generate circRNA expression profiles using RNA sequencing.
Objectives: Investigate the biomechanical characteristics in tracheostomized patients with aspiration following acquired brain injury (ABI) and further explore the relationship between the biomechanical characteristics and aspiration. Methods: This is a single-center cross-sectional study. The tracheostomized patients with aspiration following ABI and age-matched healthy controls were recruited.
View Article and Find Full Text PDFArticle Synopsis
- Diffuse midline glioma (DMG) is a type of aggressive brain tumor (GBM) without effective treatments, but a new therapy called tumor treating fields (TTFields) shows promise in extending patient survival.
- The case study describes an adult patient diagnosed with thalamus GBM after a car accident, who showed some improvement with standard treatment combined with TTFields, yet experienced growth in other tumor areas (metastases).
- The findings suggest that while TTFields can enhance survival for DMG patients, it may be insufficient for metastases in lower brain areas, highlighting the need for further research in this aspect.