Steering the Absorption Configuration of Intermediates over Pd-Based Electrocatalysts toward Efficient and Stable CO Reduction.

Palladium (Pd) catalysts are promising for electrochemical reduction of CO to CO but often can be deactivated by poisoning owing to the strong affinity of *CO on Pd sites. Theoretical investigations reveal that different configurations of *CO endow specific adsorption energies, thereby dictating the final performances. Here, a regulatory strategy toward *CO absorption configurations is proposed to alleviate CO poisoning by simultaneously incorporating Cu and Zn atoms into ultrathin Pd nanosheets (NSs).

Towards Secure Internet of Things: A Coercion-Resistant Attribute-Based Encryption Scheme with Policy Revocation.

With the development and application of the Internet of Things (IoT), the volume of data generated daily by IoT devices is growing exponentially. These IoT devices, such as smart wearable devices, produce data containing sensitive personal information. However, since IoT devices and users often operate in untrusted external environments, their encrypted data remain vulnerable to potential privacy leaks and security threats from malicious coercion.

Relationship between emotional labor strategies and the quality of work life of operating room nurses.

Introduction: Emotional labor involves regulating one's emotional state at work to align with organizational expectations. For operating room (OR) nurses, emotional labor is an inherent part of their roles, with different strategies potentially impacting their work-related quality of life (WRQoL) in distinct ways. This study aimed to examine the relationship between emotional labor strategies and WRQoL among OR nurses.

[Short-term efficacy of rituximab in children with calcineurin inhibitor resistant steroid resistant nephrotic syndrome].

To investigate the short-term efficacy and safety of rituximab (RTX) in children with calcineurin inhibitor (CNI) resistant steroid resistant nephrotic syndrome (SRNS). A retrospective case analysis was conducted. Thirteen children with CNI resistant SRNS who were regularly treated with RTX (375 mg/m per dose (maximum dose 500 mg), 1 dose per week, a total of 4 doses) in Department of Nephrology, Children's Hospital of Fudan University from January 2016 to December 2023 were enrolled.

The Association Between Gestational Age and Type 1 Diabetes Mellitus in Children and Adolescents: A Systematic Review and Network Meta-Analysis.

Background: With genetics thought to explain a portion of the overall risk of type 1 diabetes mellitus (T1DM), environmental risk factors in early life have been proposed. Previous studies on the incidence of T1DM in children or adolescents by gestational age at birth have yielded inconsistent results.

Objectives: To clarify the association between gestational age at birth and T1DM in childhood/adolescence and to offer evidence-based support for the prevention or screening of T1DM.

Promoting in-situ stability of hydroxide exchange membranes by thermally conductive network for durable water electrolysis.

Hydroxide exchange membrane (HEM) water electrolysis is promising for green hydrogen production due to its low cost and excellent performance. However, HEM often has insufficient stability in strong alkaline solutions, particularly under in-situ electrolysis operation conditions, hindering its commercialization. In this study, we discover that the in-situ stability of HEM is primarily impaired by the locally accumulated heat in HEM due to its low thermal conductivity.

Comparison of upper airway volume and hyoid position after camouflage orthodontic or orthodontic-orthognathic treatment in patients with skeletal class Ⅲ malocclusion with normal-angle vertical pattern.

Objectives: This study aims to compare the effects of two orthodontic treatment modalities for skeletal class Ⅲ malocclusion on specific changes in airway volume, morphology, palatal angle, mandibular rotation, and bone displacement. Results provide scientific evidence for the selection of orthodontic treatment plans and reduce the risk of developing obstructive sleep apnea hypopnea syndrome (OSAHS).

Methods: Thirty-six patients diagnosed with skeletal class Ⅲ malocclusion at the Department of Orthodontics, the Affiliated Stomatological Hospital of Nanjing Medical University from September 2018 to December 2023 were divided into two groups: orthodontic-orthognathic treatment group (18 patients) and camouflage orthodontic treatment group (18 patients).

Association between weight-adjusted waist index and obstructive sleep apnea among adults in the United States: data from NHANES (2005-2008 and 2015-2018).

Objective: We aimed to examine the relationship between the weight-adjusted waist index (WWI) and obstructive sleep apnea (OSA), a condition often caused by obesity, which remains unclear.

Methods: In this cross-sectional study, we analyzed data from the National Health and Nutrition Examination Survey among adults in the United States (US) aged 20 to 65 years, covering the periods 2005 to 2008 and 2015 to 2018. The study included 8278 participants; we used multivariate logistic regression, restricted cubic splines, and subgroup analyses to explore the relationship between WWI and OSA.

Adverse events associated with IL-23 and IL-12/23 inhibitors in the clinical management of psoriasis: a comprehensive pharmacovigilance analysis.

Background: Interleukin-23 (IL-23) inhibitors and the IL-12/23 inhibitor ustekinumab constitute a pivotal class of therapeutic agents employed in the clinical management of Psoriasis, a chronic immune-mediated skin disorder. Notwithstanding their therapeutic efficacy, concerns have arisen due to the emergence of multiple adverse events (AEs) associated with their usage. This study aims to provide a comprehensive examination of the distribution and characteristics of these AEs concerning IL-23 and IL-12/23 inhibitors, with a specific focus on guselkumab, tildrakizumab, risankizumab, and ustekinumab.

Gut microbial composition associated with risk of premature aging in women with Yin-deficiency constitution.

Background: Yin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body. In recent years, it has become apparent that the composition and structure of the gut microbiota play a significant role in the aging process. The imbalance of gut microbiota in YinDC may accelerate the aging process.

Hierarchical Interface Enabled by a Guest-Anionic Chemistry for High-Rate Aqueous Zinc-ion Batteries.

The poor reversibility of the zinc anode caused by interfacial side reactions and dendritic growth poses significant constraints on the practical application of aqueous zinc-ion batteries. Herein, a co-solute, acesulfame potassium, with strongly polar, zincophilic guest anions is introduced into a conventional low-concentration aqueous electrolyte. This regulation enhances the electrolyte's ionic conductivity and accelerates the desolvation process of zinc ions at the electrode/electrolyte interface.

The preparation of methacrylated oxidized konjac glucomannan hydrogel system and its treatment for diabetic wounds.

The management of diabetic wounds has become an important task for the public health system. Hydrogels are highly anticipated as modern wound dressings for the treatment of diabetic wounds, hence we have prepared a MOK-Gel using methacrylated oxidized konjac glucomannan (MOK) crosslinked with acrylamide (AM). On this basis, we have incorporated drugs such as UiO-66 loaded with sodium ferulate (SF) and deferoxamine (DFO) to develop the hydrogel wound dressing DUS@MOK-Gel (a hydrogel composed of methacrylated oxidized konjac glucomannan, loaded with DFO and UiO-66 loaded with sodium ferulate).

Layer-specific biomechanical and histological properties of normal and dissected human ascending aortas.

Recent studies have attempted to characterize the layer-specific mechanical and microstructural properties of the aortic tissues in either normal or pathological state to understand its structural-mechanical property relationships. However, layer-specific tissue mechanics and compositions of normal and dissected ascending aortas have not been thoroughly compared with a statistical conclusion obtained. Eighteen ascending aortic specimens were harvested from 13 patients with type A aortic dissection and 5 donors without aortic diseases, with each specimen further excised to obtain three tissue samples including an intact wall, an intima-media layer and an adventitia layer.

Photonic compressive sensing of microwave signals with enhanced compression ratio and frequency range via optical pulse random mixing.

We propose and demonstrate a photonic compressive sensing (PCS) scheme for microwave signals using optical pulse random mixing, significantly enhancing both the compression ratio and operating frequency range. Unlike continuous-wave laser-based PCS systems, our approach mitigates the non-ideal characteristics of the pseudo-random binary sequence (PRBS), such as sloped edges and amplitude jitters, resulting in a more ideal compression process. Additionally, the high harmonic components of the optical pulses further facilitate wideband downconversion, improving the system's operating frequency range.

Clinical features and factors associated with outcomes of antibody-negative autoimmune encephalitis in patients requiring intensive care.

Background And Objectives: Antibody-negative autoimmune encephalitis (AE) is a form of encephalitis characterized by the absence of detectable autoimmune antibodies, despite immunological evidence. However, data on management of patients with antibody-negative AE in the intensive care unit (ICU) are limited. This study aimed to explore the characteristics and subtypes of antibody-negative AE, assess the effects of immunotherapy, and identify factors independently associated with poor functional outcomes in patients requiring intensive care.

From Taxus to paclitaxel: Opportunities and challenges for urban agriculture to promote human health.

Conifers of the genus Taxus are environmentally friendly plants with significant medicinal and ecological value, contributing to the enhancement of urban living environments. Paclitaxel, a compound found in Taxus, has garnered particular research interest owing to its potent anti-cancer effects. However, traditional methods of extracting paclitaxel from Taxus are not only inefficient, but also destructive and unsustainable, posing the major risk of Taxus extinction.

Precision Medicine Proof-of-Concept Study of a TNF Inhibitor in FSGS and Treatment-Resistant Minimal Change Disease.

Background: Focal segmental glomerulosclerosis (FSGS) and treatment-resistant minimal change disease (TR-MCD) are heterogeneous disorders with subgroups defined by distinct underlying mechanisms of glomerular and tubulointerstitial injury. A non-invasive urinary biomarker profile has been generated to identify patients with intra-kidney tumor necrosis factor (TNF)-activation and to predict response to anti-TNF treatment. We conducted this proof-of-concept, multi-center, open-label clinical trial to test the hypothesis that in patients with FSGS or TR-MCD and evidence of intra-renal TNF activation based on their biomarker profile, short-term treatment with adalimumab would reverse the elevated urinary excretion of MCP-1 and TIMP-1.

Rational Design of Prussian Blue Analogues for Ultralong and Wide-Temperature-Range Sodium-Ion Batteries.

Architecting Prussian blue analogue (PBA) cathodes with optimized synergistic bimetallic reaction centers is a paradigmatic strategy for devising high-energy sodium-ion batteries (SIBs); however, these cathodes usually suffer from fast capacity fading and sluggish reaction kinetics. To alleviate the above problems, herein, a series of early transition metal (ETM)-late transition metal (LTM)-based PBA (Fe-VO, Fe-TiO, Fe-ZrO, Co-VO, and Fe-Co-VO) cathode materials have been conveniently fabricated via an "acid-assisted synthesis" strategy. As a paradigm, the FeVO-PBA (FV) delivers a superb rate capability (148.

Nanozymes with Modulable Inhibition Transfer Pathways for Thiol and Cell Identification.

The elementary mechanism and site studies of nanozyme-based inhibition reactions are ambiguous and urgently require advanced nanozymes as mediators to elucidate the inhibition effect. To this end, we develop a class of nanozymes featuring single Cu-N catalytic configurations and B-O sites as binding configurations on a porous nitrogen-doped carbon substrate (B/Cu) for inducing modulable inhibition transfer at the atomic level. The full redistribution of electrons across the Cu-N sites, induced by B-O sites incorporation, yields B/Cu with enhanced peroxidase-like activity versus Cu.

Efficacy of adalimumab in pediatric non-infectious uveitis with and without anterior segment inflammation.

Background: This study aimed to identify the clinical characteristics of cases that is related to the response rate of adalimumab (ADA) treatment.

Methods: A retrospective review of medical records was conducted for pediatric patients with non-infectious uveitis undergoing ADA treatment for a minimum of six months. The patients were stratified into two groups: those with anterior segment inflammation (ASI+) and those without anterior segment inflammation (ASI-).

Differential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair.

The cranial mesenchyme, originating from both neural crest and mesoderm, imparts remarkable regional specificity and complexity to postnatal calvarial tissue. While the distinct embryonic origins of the superior and dura periosteum of the cranial parietal bone have been described, the extent of their respective contributions to bone and vessel formation during adult bone defect repair remains superficially explored. Utilizing transgenic mouse models in conjunction with high-resolution multiphoton laser scanning microscopy (MPLSM), we have separately evaluated bone and vessel formation in the superior and dura periosteum before and after injury, as well as following intermittent treatment of recombinant peptide of human parathyroid hormone (rhPTH), Teriparatide.

Myeloid cells meet CD8 T cell exhaustion in cancer: What, why and how.

Exhausted T cell (Tex) is a specific state of T cell dysfunction, in which these T cells gradually lose their effector function and change their phenotype during chronic antigen stimulation. The enrichment of exhausted CD8 T cell (CD8 Tex) in the tumor microenvironment is one of the important reasons leading to the poor efficacy of immunotherapy. Recent studies have reported many reasons leading to the CD8 T cell exhaustion.

Network pharmacology: a crucial approach in traditional Chinese medicine research.

Network pharmacology plays a pivotal role in systems biology, bridging the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research. Network pharmacology enables researchers to construct multilayered networks that systematically elucidate TCM's multi-component, multi-target mechanisms of action. This review summarizes key databases commonly used in network pharmacology, including those focused on herbs, components, diseases, and dedicated platforms for network pharmacology analysis.