[Effect of clofelin and apressin on blood circulation and metabolic indices of the brain].

Experiments on cats were made to study the effects of clopheline (5-6 and 10 micrograms/kg) and apressin (1 mg/kg) on the time-course of changes in the cerebral circulation, total arterial and venous pressures, oxygen and glucose concentrations, pH in the arterial and venous blood. It was discovered that clopheline and apressin appreciably reduce the total blood pressure and minimize the volumetric velocity of the cerebral circulation. Brain oxygen and glucose consumption was found to be reduced under the effect of these drugs.

[Effect of clofelin and apressin on the autoregulation of cerebral blood flow].

Acute experiments on cats under mild sodium ethaminal anesthesia and local novocaine anesthesia were made to determine the autoregulative reactions (AR) of the cerebral vessels to different levels of arterial pressure (AP). After clofelin administration the autoregulation borders shifted to the right i. e.

[Effect of clofeline and apressin on systemic arterial pressure and the tone of cerebral and peripheral vessels].

Resistography was used to demonstrate in acute experiments on anesthetized cats that intravenous injection of clofelin (2,6 and 10 microgram/kg) and apressin (1, 2.5 and 5 microgram/kg) induced a dose-dependent decline in the arterial blood pressure which was not infrequently preceded by short-lived hypertension. Clofelin induced an increase in the tone of cerebral vessels while apressin reduced it.