[Effect of cadmium chloride on the processes of learning and memory in rats].

Intraperitoneal injection of cadmium chloride (4 mg/kg) to rats before elaboration or reproduction of two-way avoidance conditioned reflex (TACR) disturbs both these processes. Deterioration of elaboration does not affect connections fixation and their subsequent reproduction. Injection of the substance before the elaboration of passive avoidance conditioned reflex (PACR) depresses elaboration and consolidation.

[Vitamin E and propolis as antioxidants after excessive administration of polyunsaturated fatty acids].

Polyunsaturated fatty acids included into animals' ration (10% of linethol) intensified lipid peroxidation and increased the activity of cathepsin D, an enzyme responsible for protein and lipid degradation in the cell. Vitamin E stabilized the impaired processes. Biologically active complex of propolis produced a similar effect, however, decreased protein synthesis and a tendency to animals' body mass increment have evidenced a more pronounced antioxidative action as compared to that of vitamin E.

[Disorders in the consolidation of temporary connections in the rat after chemical induction of lipid peroxidation and its prevention with the antioxidant ionol].

Injections to rats of antibiotic adriblastin activating lipids peroxide oxidation directly after elaboration of defensive conditioned reflexes, elicit retrograde amnesia. Administration of antioxidant ional before the administration of adriblastin prevents this effect. It is suggested that activation of lipids peroxide oxidation disturbs the process of consolidation.