[Medico-biological evaluation of sodium salt of nitrofurylacrylic acid as a food additive].

Nitrofurylacrylic acid sodium salt is a substance of moderate toxicity. Its LD50 for male rats after oral administration comprises 1220 mg/kg, for female rats--1400 mg/kg. The minimal toxic dose, in case of long-term administration comprises 14 mg/kg.

[Hygienic substantiation of using new antibiotic preparations, tylosin phosphate and vitagrin as food additives].

Hygienic regulation of the use of the agents studied in animal experiments as food additives has been validated with respect to the dose level, regimen of addition and the period of waiting for slaughter. It is recommended that tylosin-phosphate should be included into the animals' ration as a food additive in a dose of 60 mg/kg for a short time (2-3 days), the period of waiting for slaughter being not less than 6-7 days. Addition of vitagrin has been recommended for young growing animals in a dose of 400-500 g/ton of feed.

[Hygienic significance of the use of feed antibiotics in animal husbandry].

Introduction of kormogrisein-10 and fradizin-10 into feeds of farm animals did not lead to accumulation in the animals' meat of grisin and tilozin residues or to an adverse effect of such meat on the body of experimental rats. In the course of oral administration of the preparations to the animals the authors determined the period of detectability of antibiotic residues in muscles and organs and the minimal toxic doses of the preparations.