[Ethyl alcohol-combined and concomitant poisonings by psychotropic agents].

The paper provides the results of examining 474 patients with acute poisonings by psychotropic agents due to their combined use or in combination with ethanol. It shows the frequency of different combinations of psuchotropic drugs and denotes the poorest of them to the outcome of disease. Concomitant poisonings are demonstrated to show a severe course and high death rates whereas poisonings combined with ethanol, if at low blood concentrations, take their better course.

[Effect of sodium hypochlorite on the biotransformation of toxicants in acute poisoning by psychotropic agents].

In acute poisoning by amitriptyline, carbazepine, barbiturates, and ethanol, the effect of sodium hypochlorite on the metabolism of toxicants is manifested as a considerable reduction in their high blood concentrations through oxidative transformation to inactive water-soluble derivatives and as the enhanced urinary elimination of the latter. The rate of the above process depends on the used dose of sodium hypochlorite.

[Laboratory changes in exo- and endotoxemia in toxicohypoxic encephalopathy occurring with acute poisoning by psychopharmacological agents].

Examinations of patients with acute oral poisoning by psychotropic agents have indicated that toxicohypoxic encephalopathy develops, when the high concentrations of toxicants and their active metabolites specifically affect brain structures, resulting in oxidative stress and impaired natural detoxification mechanisms.

[Current methods of laboratory diagnosis in acute chemical poisoning].

Physicochemical methods of analysis are used in analytical toxicology for the differential diagnosis of chemicals and drugs in acute chemical poisonings. Chromatography in its different variants (thin-layer, gas-liquid, high-pressure liquid chromatography) is the principal diagnostic method permitting identification and measurement of chemicals and drugs belonging to different classes of chemical compounds.