[Study of volatile fatty acids in the blood of patients with periodic disease].

Microecological "failures" are an important pathogenetic factor of different diseases and, in the authors' opinion, periodic disease (PD) is one of them. PD is a recessive disease characterized by fever attacks and neutrophil-mediated serous inflammation. A genetic factor has been established to be responsible for half the cases of PD, the influence of non-hereditary factors, particularly a role of the host automicroflora in the genesis of an inflammatory process, has been little studied.

[Conjugative plasmids of Salmonella strains resistant to antibiotics].

Plasmid DNA profile and conjugative R-plasmids were detected in Salmonella clinical isolates. The study revealed that drug resistance of Salmonella clinical strains of different serovars was determined by R-plasmids with a mol. wt.

[The spectrum and level of low-weight molecular compounds of microbial origin in familial Mediterranean fever].

Familial Mediterranean fever (FMF) is a disease whose etiopathogenesis is not clarified yet. The infectious theory of FMF has not been confirmed either. Nevertheless, the involvement of microbes in the trigger of an inflammatory process cannot be excluded since today's well-known pathogenetic processes in FMF are to be directly related to the key cells of an inflammatory response.

[Effect of R plasmid on cell membrane structure in Salmonella derby].

The structure of membranes of Salmonella derby cells both containing R-plasmid and free of plasmid was studied by small- and large-angle X-ray diffraction. Reflections with interplane distances of 8 and 11 A were detected, which are typical of plasmid-carrying S. derby cells.

[The role of phospholipids and their fatty acids in the structural organization of membranes of plasmid-containing and plasmid-less Salmonella derby cells].

The effect of R-plasmid on the qualitative and quantitative compositions of phospholipids and their fatty acids in bacterial (S. derby) cells has been studied. It has been found that the lack of R-plasmid in bacterial cells leads to a sharp decrease in the phospholipid content, in the phosphatidylcholine content in particular, and causes an increase in the per cent content of lysophosphatidylcholines.

[The ultrastructure of plasmid-containing and plasmid-free Salmonella derby cells].

The comparative electron-microscopic study of S. derby plasmid-containing and plasmid-free cells has revealed certain differences in their structures: These structural differences are always accompanied by changes in the form and size of the cells, the form of the cell wall with the appearance of fimbria-like processes, depending on the presence or absence of S. derby R-plasmid in the cells.

[Mechanisms of resistance of Salmonella derby cells to streptomycin].

Mechanisms of high streptomycin resistance (8000 micrograms/ml) in S. derby cells carrying R plasmids were studied. The cells were isolated from clinical materials.

[Interrelation of the sensitivity of Salmonella derby cells to phage dp8 with the R plasmid of Salmonella derby].

In the process of studying phage--Salmonella derby plasmid interaction effect, it has been found that the absence of the plasmid blocks the adsorption step and the step of phage penetration into the cell. However, the lytic functions and those responsible in maintenance of the lysogenic state are independent of plasmid. Probably, resistance of plasmidless cells of S.

[R-factor from the natural strain of Salmonella derby carrying a DNA-polymerase gene].

A R-factor which determines multiple stability to antibiotics (Cm, Pn, Sm) was found in a Salmonella derby strain isolated from the clinical material. The plasmid was eliminated by treatment with ethidium bromide; the DNA-polymerase activity in the antibiotic-sensitive derivatives measured under conditions optimal for DNA-polymerase I from E. coli was found to be decreased 10-50-fold.