Publications by authors named "Zezu Qin"
Background: Muscle-invasive bladder cancer (MIBC) is a prevalent cancer characterized by molecular and clinical heterogeneity. Assessing the spatial heterogeneity of the MIBC microenvironment is crucial to understand its clinical significance.
Methods: In this study, we used imaging mass cytometry (IMC) to assess the spatial heterogeneity of MIBC microenvironment across 185 regions of interest in 40 tissue samples.
Article Synopsis
- Muscle invasive bladder cancer (MIBC) is a serious condition associated with high rates of metastasis and limited treatment options, where immune checkpoint inhibitors (ICIs) show potential as a new therapy.
- A detailed analysis of tumor samples identified specific cancer stem cell-like populations, particularly those expressing IGF2BP3, which are linked to immune suppression and poorer survival outcomes in MIBC patients.
- Research on IGF2BP3 revealed its significant role in regulating key genes and pathways, suggesting that targeting this gene could be vital for developing more effective immunotherapy strategies against MIBC.