Publications by authors named "Zeyun Zhu"
Article Synopsis
- Amyloid fibrils of α-synuclein are linked to Parkinson's disease, with the C-terminal's intrinsically disordered region (IDR) playing a key role in receptor interactions that promote disease progression.
- Researchers identified a compound called Givinostat (GS) through high-throughput screening that effectively disrupts these interactions and developed a lead compound, GSD-16-24, by optimizing GS.
- GSD-16-24 binds to the C-terminal IDR of α-syn, blocking fibril-receptor binding, which reduces neuronal spread and inflammation linked to Parkinson's, suggesting a new therapeutic strategy.
The mitochondrial caseinolytic protease P (ClpP) is a target candidate for treating leukemia; however, the effects of ClpP modulation on solid tumors have not been adequately explored. Here, we report a potent activator of ClpP with the therapeutic potential for pancreatic ductal adenocarcinoma (PDAC). We first validated that aberrant ClpP activation leads to growth arrest of PDAC cells and tumors.
View Article and Find Full Text PDFMillions of people worldwide suffer from acute or chronic liver inflammation caused by the hepatitis C virus (HCV). Metal ion chelators have achieved widespread success in the development of antiviral drugs. Some inhibitors with metal ion chelating structures have been proven to have good inhibitory activities on non-structural protein 5B (NS5B) polymerase.
View Article and Find Full Text PDFArticle Synopsis
- Parkinson's disease (PD) is a common neurodegenerative disorder, and early diagnosis is crucial yet challenging.
- Researchers have created new compounds called styrylaniline derivatives that can bind to alpha-synuclein (α-syn) aggregates, which are linked to PD.
- One particular compound, 7-16, not only effectively detects these aggregates in cells and mouse models but also can cross the blood-brain barrier, indicating its potential for use in imaging agents for PD diagnosis.