cultured calculus bovis alleviates cerebral ischemia-reperfusion injury in rats through regulating microglial polarization and inhibiting NLRP3.

Objectives: To investigate the effect of cultured calculus bovis (ICCB) on cerebral ischemia/reperfusion injury (CIRI) and its mechanism.

Methods: The CIRI animal model and cell model were induced by middle cerebral artery occlusion (MCAO) in Sprague Dawley rats and oxygen glucose deprivation/reperfusion (OGD/R) in BV2 cells, respectively. The CIRI of rat model was evaluated using modified neurological severity score (mNSS), brain water content, and cerebral infarction volume after 1.

Protective Effect of Piceatannol Against Cerebral Ischaemia-Reperfusion Injury Via Regulating Nrf2/HO-1 Pathway In Vivo and Vitro.

Piceatannol is a natural plant-derived compound with protective effects against cardiovascular diseases. However, its effect on cerebral ischaemia-reperfusion injury (CIRI) induced by oxidative stress remains unclear. This study aimed to investigate piceatannol's antioxidation in CIRI.