The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumours of the digestive tract and poses a serious threat to human life. This study first analysed two GEO datasets (GSE166705 and GSE115018) to screen for differentially expressed lncRNAs between HCC and adjacent tissues. The lncRNA lnc-POTEM-4:14 was determined via a series of methods to be closely related to liver cancer.

The source-specific health risk and biological effect assessment of PAHs in Mactra veneriformis from the Bohai Sea and Yellow Sea.

Source-specific risk assessment has been widely used to analyze the source of pollution risk instead of pollutant content for more accurate control of pollution. However, due to limitations in data type, assessment of source-specific biological effect has not been reported, which is highly significant for organism protection. This study conducted a comprehensive assessment of the health risk and biological effect of polycyclic aromatic hydrocarbons (PAHs) bioaccumulated in the clam Mactra veneriformis from two typical bays in China.

Nanomaterials for Zinc Batteries-Aerogels.

Aqueous zinc batteries, mainly including Zn-ion batteries (ZIBs) and Zn-air batteries (ZABs), are promising energy storage systems, but challenges exist at their current stage. For instance, the zinc anode in aqueous electrolyte is impacted by anodic dendrites, hydrogen and oxygen precipitation, and some other harmful side reactions, which severely affect the battery's lifespan. As for traditional cathode materials in ZIBs, low electrical conductivity, slow Zn ion migration, and easy collapse of the crystal structure during ion embedding and migration bring challenges.

A structural equation model for assessing toxic effects of polycyclic aromatic hydrocarbons on scallop Chlamys farreri and the establishment of a novel integrated biomarker index.

Persistent organic pollutants (POP) occur in coastal areas worldwide and seriously affect marine ecosystems, especially aquatic organisms. Here, we assessed the bioaccumulation, biological effects, and health risks of polycyclic aromatic hydrocarbons (PAHs), one typical kind of global POPs, in the scallop Chlamys farreri from typical bays of the Yellow Sea and the Bohai Sea, China. Results revealed higher PAH bioaccumulation in scallops from Laizhou Bay and Jiaozhou Bay compared to Rushan Bay and Haizhou Bay.

Community social capital and depressive symptoms among older adults relocated for poverty alleviation in Shanxi, China: a cross-sectional study.

Background: Depression is one of the most common mental health problems in older adults. Community social capital and depressive symptoms in older adults have been discussed in previous studies but remain limited. This study aims to explore the association between community social capital and depressive symptoms among older adults relocated for poverty alleviation in China.

Study on the detoxification and toxic effects of clam Ruditapes philippinarum exposed to 2,6-ditert-butyl-4-methylphenol (BHT): Oxidative stress, neurotoxicity, respiratory toxicity, and immunotoxicity.

The bioaccumulation and toxic effects of synthetic phenolic antioxidants (SPAs) in aquatic ecosystems are of growing concern due to their widespread use and potential environmental persistence. This study investigated the detoxification and toxicological impacts of 2,6-ditert-butyl-4-methylphenol (BHT), a representative SPAs, on clams Ruditapes philippinarum using environmentally relevant exposure concentrations. BHT bioaccumulation was observed in both gills and digestive glands, with higher levels in the latter.

The application of multi-scale simulation in advanced electronic packaging.

Electronic packaging is an essential branch of electronic engineering that aims to protect electronic, microelectronic, and nanoelectronic systems from environmental conditions. The design of electronic packaging is highly complex and requires the consideration of multi-physics phenomena, such as thermal transport, electromagnetic fields, and mechanical stress. This review presents a comprehensive overview of the multiphysics coupling of electric, magnetic, thermal, mechanical, and fluid fields, which are crucial for assessing the performance and reliability of electronic devices.

Zfp260 choreographs the early stage osteo-lineage commitment of skeletal stem cells.

The initial fine-tuning processes are crucial for successful bone regeneration, as they guide skeletal stem cells through progenitor differentiation toward osteo- or chondrogenic fate. While fate determination processes are well-documented, the mechanisms preceding progenitor commitment remain poorly understood. Here, we identified a transcription factor, Zfp260, as pivotal for stem cell maturation into progenitors and directing osteogenic differentiation.

PICH, A protein that maintains genomic stability, can promote tumor growth.

Genomic instability is regardedas a hallmark of cancer cells. It can be presented in many ways, among which chromosome instability has received attention. Ultrafine anaphase bridges are a typeof chromatin bridges, the untimely resolution of which can also lead to chromosome instability.

A Review of Carbon Anode Materials for Sodium-Ion Batteries: Key Materials, Sodium-Storage Mechanisms, Applications, and Large-Scale Design Principles.

Sodium-ion batteries (SIBs) have been proposed as a potential substitute for commercial lithium-ion batteries due to their excellent storage performance and cost-effectiveness. However, due to the substantial radius of sodium ions, there is an urgent need to develop anode materials with exemplary electrochemical characteristics, thereby enabling the fabrication of sodium-ion batteries with high energy density and rapid dynamics. Carbon materials are highly valued in the energy-storage field due to their diverse structures, low cost, and high reliability.

Studies on the characteristics of polycyclic aromatic hydrocarbons accumulation in lipids and the disturbance of lipid metabolism of Ruditapes philippinarum.

Polycyclic aromatic hydrocarbons (PAHs) constitute a class of persistent organic pollutants with strong lipophilicity, which readily accumulate within organisms and have the effect to induce disorders in lipid metabolism. The present study aimed to investigate the accumulation localization and pattern of PAHs in Ruditapes philippinarum, and to reveal the association between PAHs and lipids metabolism. The 21-day exposure experiment was conducted using a mixture of phenanthrene, chrysene, and benzo[a]pyrene (the proportion is 1:1:1) at concentrations of 0.

Antifungal Activity and Mechanisms of 2-Ethylhexanol, a Volatile Organic Compound Produced by sp. NAU1697, against f. sp. .

Researchers often consider microorganisms from sp. to be beneficial for plants. In this study, the biocidal effects and action mechanisms of volatile organic compounds (VOCs) produced by sp.

Rotenone activates the LKB1-AMPK-ULK1 signaling pathway to induce autophagy and apoptosis in rat thoracic aortic endothelial cells.

Background: The specific mechanism by which rotenone impacts thoracic aortic autophagy and apoptosis is unknown. We aimed to investigate the regulatory effects of rotenone on autophagy and apoptosis in rat thoracic aortic endothelial cells (RTAEC) via activation of the LKB1-AMPK-ULK1 signaling pathway and to elucidate the molecular mechanisms of rotenone on autophagy and apoptosis in vascular endothelial cells.

Methods: In vivo, 60 male SD rats were randomly selected and divided into 5 groups: control (Con), DMSO, 1, 2, and 4 mg/kg groups, respectively.

Synthesis of Ultrathin High-Entropy Oxides with Phase Controllability.

High-entropy oxides (HEOs) with an ultrathin geometric structure are especially expected to exhibit extraordinary performance in different fields. The phase structure is deemed as a key factor in determining the properties of HEOs, rendering their phase control synthesis tempting. However, the disparity in intrinsic phase structures and physicochemical properties of multiple components makes it challenging to form single-phase HEOs with the target phase.

Interference mechanism of benzo[a]pyrene exposure on the taste substance metabolisms in Ruditapes philippinarum.

Aquatic animals are popular for their unique umami and high-quality protein. However, under the realistic background of increasing marine pollution, whether it affects the aquatic animal tastes, and what the interference mechanism is still remains unknown. Benzo[a]pyrene (B[a]P) is a typical Polycyclic aromatic hydrocarbons (PAHs) with high toxicity.

Association of Life's Essential 8 with osteoarthritis in United States adults: mediating effects of dietary intake of live microbes.

Objective: Osteoarthritis (OA) is associated with cardiovascular disease and represents a persistent economic and physical burden on patients in the United States. This study evaluated the mediating effect of dietary live microbe intake on the association between cardiovascular health [based on Life's Essential 8 (LE8) scores] and osteoarthritis (OA) in adults.

Methods: This cross-sectional study included data from the National Health and Nutrition Examination Survey, 1999-2019 (from patients aged ≥20 years).

Study on epigenotoxicity, sex hormone synthesis, and DNA damage of benzo[a]pyrene in the testis of male Ruditapes philippinarum.

Research on the mechanisms of reproductive toxicity caused by persistent organic pollutants (POPs) in marine animals has received significant attention. One group of typical POPs, called polycyclic aromatic hydrocarbons (PAHs), has been found to cause various reproductive toxicities in aquatic organisms, including epigenotoxicity, reproductive endocrine disruption, DNA damage effects and other reproductive toxicity, thereby affecting gonadal development. Interestingly, male aquatic animals are more susceptible to the disturbance and toxicity of environmental pollutants.

The assessment of bioavailability and environmental risk of dissolved and particulate polycyclic aromatic hydrocarbons in the seawater of typical bays.

The pollution of dissolved and particulate polycyclic aromatic hydrocarbons (PAHs) in coastal waters has been increasing in recent decades. However, limited research has been conducted on the characteristics of dissolved and particulate PAHs in seawater and their associated risk assessment. Here, we focused on the bioavailability and environmental risk of PAHs in four typical bays of Shandong Province, China, and used scallop Chlamys farreri and clam Mactra veneriformis as sentinel species.

FBXL19 promotes malignant behaviours by activating MAPK signalling and negatively correlates with prognosis in hepatocellular carcinoma.

FBXL19 is a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases and is linked to a variety of vital biological processes, such as cell proliferation, migration, and differentiation. Previous studies have identified it as an oncogene in breast cancer and glioma. However, its role in hepatocellular carcinoma (HCC) remains unclear.

Source-specific ecological and health risks of polycyclic aromatic hydrocarbons in the adjacent coastal area of the Yellow River Estuary, China.

Industrialization and urbanization have led to increasing levels of PAH pollution in highly urbanized estuaries and their adjacent coastal areas globally. This study focused on the adjacent coastal area of the Yellow River Estuary (YRE) and collected surface seawater, surface sediment, and clams and at four sites (S1 to S4) in May, August, and October 2021 to analyze the source-specific ecological and health risks and bioeffects. The findings revealed that the main sources of PAHs were traffic emission (25.

Study on reproductive endocrine disturbance and DNA damage mechanism of female Ruditapes philippinarum under Benzo[a]pyrene stress.

The reproductive toxicity of polycyclic aromatic hydrocarbons (PAHs) in aquatic organisms has attracted increasing attention from scholars. Currently, research in this field primarily focuses on vertebrates such as zebrafish and other model species. However, there is still a significant knowledge gap in the toxicity of PAHs to invertebrates and its potential mechanisms.