Multi-watt picosecond 1.7 µm Tm-doped fiber laser amplification system.

We report on a multi-watt, high-repetition-rate picosecond 1.7 µm Tm-doped fiber (TDF) laser amplification system. The seed oscillator is a figure-9 passively mode-locked TDF laser, which delivers a pulse train with a center wavelength of 1738nm and a fundamental repetition rate of ∼85 MHz.

Metformin acts on miR-181a-5p/PAI-1 axis in stem cells providing new strategies for improving age-related osteogenic differentiation decline.

A general decline in the osteogenic differentiation capacity of human bone marrow mesenchymal stem cells (hBMSCs) in the elderly is a clinical consensus, with diverse opinions on the mechanisms. Many studies have demonstrated that metformin (MF) significantly protects against osteoporosis and reduces fracture risk. However, the exact mechanism of this effect remains unclear.

Identification and expression analysis of dmc1 in Chinese soft-shell turtle (Pelodiscus sinensis) during gametogenesis.

DNA meiotic recombinase 1 (disrupted meiotic cDNA, Dmc1) protein is homologous to the Escherichia coli RecA protein, was first identified in Saccharomyces cerevisiae. This gene has been well studied as an essential role in meiosis in many species. However, studies on the dmc1 gene in reptiles are limited.

Exploration of anti‑osteosarcoma activity of asiatic acid based on network pharmacology and experiments.

Osteosarcomas are malignant bone tumors that typically originate in the epiphyses of the long bones of the extremities in adolescents. Asiatic acid has been reported to possess anti‑inflammatory, neuroprotective, antidiabetic, antitumor and antimicrobial activities. The present study used a combination of network pharmacological prediction and experimental validation to explore the potential pharmacological mechanism of asiatic acid against osteosarcoma.

Anti-phase pulsation of counter-propagating dissipative solitons in a bidirectional fiber laser.

Due to its unique geometric structure, the bidirectional ultrafast fiber laser is an excellent light source for dual-comb applications. However, sharing the same gain between the counter-propagating solitons also gives rise to complex dynamics. Herein, we report the anti-phase pulsation of counter-propagating dissipative solitons in a bidirectional fiber laser.

1.7 µm figure-9 Tm-doped ultrafast fiber laser.

The evolution of multiphoton microscopy is critically dependent on the development of ultrafast laser technologies. The ultrashort pulse laser source at 1.7 µm waveband is attractive for in-depth three-photon imaging owing to the reduced scattering and absorption effects in biological tissues.

Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways.

Baicalin, a flavonoid derivative, exerts antitumor activity in a variety of neoplasms. However, whether baicalin exerts antitumor effects on osteosarcoma cells remains to be elucidated. In this study, treatment with baicalin reduced the proliferation and invasive potential of osteosarcoma cells and reduced the mitochondrial membrane potential, which eventually caused mitochondrial apoptosis.

1.7 µm Tm-fiber chirped pulse amplification system with dissipative soliton seed laser.

We report on a 1.7 µm Tm-fiber chirped pulse amplification (CPA) system by virtue of a broadband dissipative soliton seed laser. The seed oscillator delivers the dissipative soliton with 10 dB spectral bandwidth of 23 nm and an average power of 4 mW.