Publications by authors named "Zeynep Arzu Yegin"
Background: Hematopoietic stem cell transplantation (HSCT) is a critical treatment for various hematologic malignancies but can lead to complications, including ototoxicity.
Aim/objectives: This study aims to explore the relationship between patient-specific factors and ototoxicity in adult HSCT patients.
Material And Methods: We conducted a retrospective analysis of 129 adult patients who underwent HSCT between 2003 and 2020.
Background: The coexistence of sepsis and hematological malignancies increases patient vulnerability, revealing the need for precise prognostic markers. This study explores the prognostic significance of lactate levels and clearance in septic patients with hematological malignancies.
Materials And Methods: A retrospective cohort study from January 2016 to December 2019 in a tertiary hematological intensive care unit (ICU) included 167 adults with hematological malignancies and sepsis.
Background: Magnesium (Mg) is an essential element that is required as a cofactor for many cellular reactions, including immunologic pathways. The aim of this study was to investigate the potential impact of serum Mg levels on allogeneic hematopoietic stem cell transplantation (alloHSCT) outcomes.
Methods: Medical records of 340 alloHSCT recipients (median age: 45 [18-71] years; M/F: 210/130) were reviewed for this retrospective study.
Article Synopsis
- * A study involving 1439 acute leukemia patients showed that 6% had a prior history of IA before receiving alloSCT, resulting in higher non-relapse mortality (17.3% for those with IA compared to 11.2% for those without), and poorer outcomes in terms of relapse-free and overall survival rates.
- * Despite the challenges linked to pre-SCT IA, over two-thirds of patients with this condition were alive one
Autologous stem cell transplantation (ASCT) remains the mainstay of the treatment in newly diagnosed transplant-eligible multiple myeloma (MM) patients. This retrospective study was performed to investigate the potential prognostic markers which may modify transplant course in a total of 256 ASCT recipients [median age: 58 (30-74) years; male/female: 138/118], including pretransplant (PET) and day + 60 (PET) PET/CT assessments and comparative analysis of melphalan (Mel) dose. Better responses with significantly higher complete response/very good partial response rates were achieved in patients who proceeded to transplant within 301 days from diagnosis (p < 0.
View Article and Find Full Text PDFAllogeneic hematopoietic stem cell transplantation (alloHCT) is associated with severe complications, most of which share a common physiopathological background characterized by endothelial dysfunction. A novel risk assessment model, endothelial activation and stress index (EASIX), has been introduced as a predictor of endothelial activation. This retrospective study was performed to evaluate the predictive impact of EASIX/modified-EASIX (mEASIX) on transplant outcome.
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- * In a study of 90 patients, flow cytometry (FCM) showed higher sensitivity (94.2%) compared to cytology (68.5%) for diagnosing CNS involvement, although cytology remains the gold standard.
- * The findings suggest that FCM could be a valuable routine diagnostic tool alongside cytology, as it can detect smaller numbers of malignant cells more effectively and offers quicker results.
Article Synopsis
- Opportunistic fungal infections like invasive aspergillosis (IA) are a significant health threat for immunocompromised patients, with around 250,000 cases yearly, and early diagnosis and treatment can help lower mortality rates.
- This study aimed to evaluate the effectiveness of two diagnostic tests—galactomannan and beta-glucan—for diagnosing invasive pulmonary aspergillosis (IPA) in 60 patients at Gazi University Hospital.
- Results showed that the galactomannan test had a sensitivity of 77.8% and specificity of 96.7%, while the beta-glucan test had a lower sensitivity of 61.1%, highlighting the relevance of risk factors like steroid use in IPA development.
Introduction: COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients.
Methods: This study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic.
Results: The median age was 50.
Background: Patients with hematological malignancies (HM) often require admission to the intensive care unit (ICU) due to organ failure, disease progression or treatment-related complications, and they generally have a poor prognosis. Therefore, understanding the factors affecting ICU mortality in HM patients is important. In this study, we aimed to identify the risk factors for ICU mortality in our critically ill HM patients.
View Article and Find Full Text PDFFollowing the introduction of tyrosine kinase inhibitors (TKI), the number of patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) for chronic phase (CP) chronic myeloid leukemia (CML) has dramatically decreased. Imatinib was the first TKI introduced to the clinical arena, predominantly utilized in the first line setting. In cases of insufficient response, resistance, or intolerance, CML patients can subsequently be treated with either a second or third generation TKI.
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- Multiple myeloma (MM) is a cancer primarily affecting older adults, and this study focused on assessing the health and functionality of newly diagnosed patients before and after treatment.
- The study involved 37 patients aged 50 and older, measuring their performance status and conducting a comprehensive geriatric assessment (CGA) at diagnosis and after 4 cycles of induction chemotherapy.
- Findings indicated that 40.7% of patients showed improvement in performance status post-treatment, with frail patients and those with more health issues experiencing less improvement, suggesting CGA can help predict potential recovery and suitability for future treatments like transplants.
Poor graft function (PGF) and secondary failure of platelet recovery (SFPR) are significant causes of transplant related morbidity and mortality. Although thrombopoietin receptor agonists (TPO-RA), particularly Eltrombopag (EPAG), have been reported to be efficacious in the treatment of prolonged thrombocytopenia, potential long term adverse effects remain to be elucidated. This retrospective study was performed to determine the efficacy and toxicity profile of TPO-RAs in allogeneic hematopoietic stem cell transplant (alloHCT) recipients.
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- * A study compared daily versus every other day oral iron supplementation in premenopausal women with IDA, finding significant improvements in hemoglobin and other iron-related measurements in both groups after 2 months.
- * Although hepcidin levels were slightly higher in the every other day group, there was no significant difference, suggesting that less frequent dosing can improve patient compliance while maintaining similar effectiveness.
Graft cellular composition is considered as a significant determinant of transplant outcome. Donor CD3 cells were shown to have a significant association with the development of graft vs host disease (GvHD). The aim of this study was to investigate the impact of graft CD3 cell content on transplant outcome, particularly in terms of GvHD and relapse.
View Article and Find Full Text PDFObjective: Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in patients with hematological malignancies, is a point of interest. We aimed to analyze the symptoms, complications, intensive care unit admissions, and mortality rates of patients with hematological malignancies infected with SARS-CoV-2 in Turkey.
View Article and Find Full Text PDFBackground: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a curable treatment modality for hematologic disorders. Transplant-related mortality remains high despite prominent scientific and technologic improvements. In consideration with the potential impact of patient- and disease-related factors on transplant outcome, this retrospective study was performed to investigate the predictive role of pretransplant HCT-composite risk (HCT-CR) score in allo-HCT recipients.
View Article and Find Full Text PDFJAK1/2 inhibitor ruxolitinib (RUX) is approved in patients with myelofibrosis but the impact of pretreatment with RUX on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) remains to be determined. We evaluated the impact of RUX on outcome in 551 myelofibrosis patients who received HSCT without (n = 274) or with (n = 277) RUX pretreatment. The overall leukocyte engraftment on day 45 was 92% and significantly higher in RUX responsive patients than those who had no or lost response to RUX (94% vs.
View Article and Find Full Text PDFBackground/aim: The aim of the study was to investigate whether treating haematological malignancy (HM) patients in a separate intensive care unit (ICU) would reduce ICU mortality.
Materials And Methods: HM patients treated by the same ICU team in a general medical ICU (GM-ICU) and a separate haematology ICU (H-ICU) were included in this study. Patients’ demographic characteristics and ICU data were recorded retrospectively.
Article Synopsis
- The study aimed to analyze the characteristics and outcomes of hematopoietic stem cell transplant (HSCT) patients admitted to the Hematology ICU due to infections from 2014 to 2017.
- Out of 62 patients, the major reasons for ICU admission included sepsis and acute respiratory failure, with a high overall mortality rate of 45.2%, primarily influenced by APACHE II scores.
- The research found that both pre-existing and new infections played a significant role in ICU morbidity and mortality, with pneumonia being the most common new infection and no significant differences in outcomes between autologous and allogeneic HSCT patients.
Introduction: Epstein-Barr virus (EBV) is associated with different types of human malignancies, including Burkitt lymphoma, nasopharyngeal carcinoma, and lymphomas. We retrospectively investigated the presence of EBV-DNA by real-time PCR in clinical samples of patients diagnosed as having hematologic malignancies while investigating the cause of lymphoproliferative disorders, and investigated its relationship to clinical manifestations.
Patients And Methods: Fifty clinical samples sent to Gazi University's hematology clinics between November 2013 and March 2018 were included.
Autologous Hematopoietic Stem Cell Transplantation (auto-HSCT) has become a therapeutic option for first-line consolidation in Acute Myeloid Leukemia (AML) patients with favorable and intermediate risk features. A total of 101 AML patients in first complete remission, who were not eligible for allogeneic HSCT, were randomized to receive intensive cytarabine-based chemotherapy or to undergo auto-HSCT. The probability of LFS was significantly better in auto-HSCT recipients compared to chemotherapy arm (43% 4.
View Article and Find Full Text PDFBackground: Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).
Methods: This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019.
Results: We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes.
Objectives: Several studies described single nucleotide polymorphisms (SNPs) on pattern recognition receptor (PRR) such as toll-like receptors (TLRs), dendritic cell-associated C-type lectin-1 (Dectin-1/CLEC7A) genes of patients with invasive fungal infections (IFIs) caused by Candida and Aspergillus. We screened TLR4, Dectin-1 and PTX3 polymorphisms in a Turkish population with invasive aspergillosis (IA) underlying haematological malignancies.
Methods: In this case-control study, a cohort of 59 patients with haematological malignancies were included.