Publications by authors named "Zeynab Izadi Najaf Abadi"
Conventional cancer vaccines based on soluble vaccines and traditional adjuvants have produced suboptimal therapeutic efficacy in clinical trials. Thus, there is an urgent need for vaccine technologies that can generate potent T cell responses with strong anti-tumor efficacy. We have previously reported the development of synthetic high-density protein (sHDL) nanodiscs for efficient lymph node (LN)-targeted co-delivery of antigen peptides and CpG oligonucleotides (a Toll-like receptor-9 agonist).
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- Cancer stem cells (CSCs) play a significant role in tumor growth, spread, and recurrence, but effective targeting methods remain unclear.
- Researchers have found that aldehyde dehydrogenase (ALDH) is a key marker for isolating CSCs and have developed a vaccination approach targeting ALDH.
- The study shows that using synthetic high-density lipoprotein nanodiscs for vaccination can enhance immune responses against ALDH CSCs, and when combined with anti-PD-L1 therapy, it leads to strong antitumor effects and longer survival in mouse models, opening new possibilities for cancer immunotherapy.