Reduction in the time of surgical procedures via a safe one-step disinfection modification to the minimally invasive McKeown esophagectomy.

The standard technique for McKeown's minimally invasive esophagectomy (MIE) involves a three-stage procedure that requires repositioning and secondary skin disinfection within the transition. Prolonged surgical times such as lobectomy and hysterectomy may be associated with an increased incidence of post-surgical complications. We introduced a one-step disinfection technique designed to facilitate esophageal cancer resection of oesophageal cancer by retrospectively analyzing 63 patients with oesophageal cancer who underwent MIE by the same surgeon.

Poor serum uric acid control increases risk for developing hypertension: a retrospective cohort study in China.

Background: Serum uric acid (SUA) has been suggested as a contributor of hypertension. However, reports on the relationship between changes in SUA and hypertension are limited. Hence, we aimed to investigate the potential impact of SUA, especially its change over time, on hypertension incidence.

Electrochemically Driven C4-Selective Decyanoalkylation of Cyanopyridines with Unactivated Alkyl Bromides Enabling C(sp)-C(sp) Coupling.

With cyanopyridines and alkyl bromides as coupling partners, an electrochemically driven C4-selective decyanoalkylation has been established to access diverse 4-alkylpyridines in one step. The reaction proceeds through the single electron reduction/radical-radical coupling tandem process under mild electrolytic conditions, achieving the cleavage of the C(sp)-CN bond and the formation of C(sp)-C(sp). The practicality of this protocol is illustrated by no sacrificial anodes, a broad substrate scope, and gram-scale synthesis.

A fluorescent screening method for optimization of conotoxin expression in Pichia pastoris.

Conotoxins are small cysteine-rich peptides secreted by the Conus venom glands, which act on ion channels or membrane receptors with high specificity and potency. Conotoxins are invaluable sources for neuroscience research and drug leads, but their application is hindered by the limited successes in quantitative engineering using either chemical or biotechnological approaches. Here, we explore the Pichia pastoris to express 23 selected conopeptides using a GFP-based fluorescence screen.

Diagnostic performance of circulating exosomes in human cancer: A meta-analysis.

Background: Cancer has become a public health problem with high morbidity and mortality. Recent publications have shown that exosomes can be used as potential diagnostic biomarkers of cancer. However, the diagnostic accuracy and reliability of circulating exosomes remain unclear.

A nomogram for predicting 5-year incidence of type 2 diabetes in a Chinese population.

Purpose: To develop a nomogram for predicting 5-year incidence of type 2 diabetes (T2D) in Chinese adults.

Methods: This is a retrospective cohort study from a prospectively collected database. We included a total 32,766 adults free of T2D at baseline with a median follow-up of 3 years.