Activated PARP1/FAK/COL5A1 signaling facilitates the tumorigenesis of cholesterol-resistant ovarian cancer cells through promoting EMT.

Cancer cells require plentiful cholesterol for membrane biogenesis and other functional needs due to fast proliferating, leading to the interaction of cholesterol or its metabolites with cancer-related pathways. However, the impact of long-lasting high cholesterol concentrations on tumorigenesis and its underlying mechanisms remains largely unexplored. To the best of our knowledge, this study is the first to establish a cholesterol-resistant ovarian cancer cells, whose intracellular total cholesterol level up to 6-8 mmol/L.

RADIOACTIVE AEROSOL SEPARATION CHARACTERISTICS STUDY OF A NOVEL SUBMICRON VIRTUAL IMPACTOR.

With the intention of man-made radioactive aerosol separating and monitoring in a high radon environment, in this paper, a novel submicron virtual impactor was developed, and a numerical simulation model was established. Then, the rationality of the numerical method was validated by comparison to experimental data. Afterward, the variations of separation characteristics under different operating conditions of sample flow rate, minor flow ratio and clean air velocity ratio were discussed and analyzed in detail.

Two-dimensional SnO anchored biomass-derived carbon nanosheet anode for high-performance Li-ion capacitors.

Lithium-ion capacitors (LICs) combine the advantages of both batteries and supercapacitors; they have attracted intensive attention among energy conversion and storage fields, and one of the key points of their research is the exploration of suitable battery-type electrode materials. Herein, a simple and low-cost strategy is proposed, in which SnO particles are anchored on the conductive porous carbon nano-sheets (PCN) derived from coffee grounds. This method can inhibit the grain coarsening of Sn and the volume change of SnO effectively, thus improving the electrochemical reversibility of the materials.

PPy coated nanoflower like CuCoObased ongrowth of nanoporous copper for high-performance supercapacitor electrodes.

General CuCoOelectrodes suffer a very low reversible capacity and poor cycling stability because of easily fading phenomena and volume change during cycling. To optimize the electrode, a facile method is conducted to fabricate a novel electrode of Cu@CuCoO@polypyrrole nanoflowers. Due to larger specific surface area and more electrochemical reactive areas of CuCoO@polypyrrole nanoflowers, the pseudocapacitance of thegrown CuCoO@polypyrrole (912 F gat 2 A g) is much higher than the pristine CuCoO(618 F gat 2 A g).

MicroRNA-451a attenuates angiotensin II-induced cardiac fibrosis and inflammation by directly targeting T-box1.

Hypertension or angiotensin II (Ang II) induces cardiac inflammation and fibrosis, thus contributing to cardiac remodeling. MicroRNAs (miRNAs) are considered crucial regulators of cardiac homeostasis and remodeling in response to various types of stress. It has been reported that miR-451a is involved in regulating ischemic heart injury.