Hyaluronic acid-cyclodextrin encapsulating paeonol for treatment of atopic dermatitis.

The cyclodextrin (CD) was grafted onto hyaluronic acid (HA) to form a topical delivery carrier (HACD) in which Paeonol was loaded in its CD cavity and self-assemble into the polymeric micelles (HACD-PAE) for the treatment of atopic dermatitis. Fluorescence microscope observed that HACD could fast penetrate into the skin and remain stable within 12 h. In vitro penetration test (IVPT) results showed the PAE retentions of HACD-PAE group in the stratum corneum and dermis were 3.

Satellite observations and modeling of oil spill trajectories in the Bohai Sea.

On June 4 and 17, 2011, separate oil spill accidents occurred at two oil platforms in the Bohai Sea, China. The oil spills were subsequently observed on different types of satellite images including SAR (Synthetic Aperture Radar), Chinese HJ-1-B CCD and NASA MODIS. To illustrate the fate of the oil spills, we performed two numerical simulations to simulate the trajectories of the oil spills with the GNOME (General NOAA Operational Modeling Environment) model.