Studies on the alleviating effect of V9 on dextran sodium sulfate-induced colitis in mice.

Background: Inflammatory bowel disease (IBD) has become a global public health problem with complex pathogenesis and limited therapeutic options. We aimed to investigate the potential mechanisms by which V9 (V9) alleviated colitis in a dextran sodium sulfate-induced colitis model mice.

Methods: Mice were induced to develop colitis by drinking DSS solution to induce colitis.

The impact of cerebral small vessel disease burden on prognosis in patients with acute coronary syndrome.

Background: Acute coronary syndrome (ACS) presents with a variable prognosis, posing significant public health challenges. This study investigated the potential link between cerebral small vessel disease (CSVD) burden and outcomes in patients with ACS.

Methods: In this retrospective cohort study, ACS patients admitted to Beijing Friendship Hospital, Capital Medical University, Beijing, China from January 2020 to October 2021, were analyzed.

A Quantitative Arrott Analysis Methodology for Magnetic Susceptibility of Microscale Ferromagnetic Nanoflakes.

Probing magnetic susceptibility of a microsized ferromagnet is a long-standing problem in condensed matter physics. Among various measuring methods for magnetic susceptibility including vibrating sample magnetometry and superconducting quantum interference device magnetometry, almost all require large-scale bulk samples or thick films. However, the quantitative measurement for magnetic susceptibility on a microscale nanoflake is a great challenge.

CAR-Macrophage Therapy Alleviates Myocardial Ischemia-Reperfusion Injury.

Background: Given the growing acknowledgment of the detrimental effects of excessive myocardial fibrosis on pathological remodeling after myocardial ischemia-reperfusion injury (I/R), targeting the modulation of myocardial fibrosis may offer protective and therapeutic advantages. However, effective clinical interventions and therapies that target myocardial fibrosis remain limited. As a promising chimeric antigen receptor (CAR) cell therapy, whether CAR macrophages (CAR-Ms) can be used to treat I/R remains unclear.

Incorporation of Graphene Oxide Quantum Dots in Gradient Layers of Polyethersulphone Nanofiltration Membranes for Nitrate Rejection from Aqueous Solution.

Graphene oxide quantum dots (GOQDs) have been widely used to prepare nanofiltration membranes due to the merits of excellent dispersity, ultrasmall size, and unique properties related to graphene. In this study, we first prepared the polyethersulphone-based nanofiltration (PES-NF) membrane via an interfacial polymerization process using a piperazine and -phenylenediamine mixed solution as the aqueous phase. Then GOQDs were incorporated into the top-down gradient structured layers (i.

Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice.

The kidney is vulnerable to ischemia and reperfusion (I/R) injury that can be fatal after major surgery. Currently, there are no effective treatments for I/R-induced kidney injury. Trimethylamine N-oxide (TMAO) is a gut-derived metabolite linked to many diseases, but its role in I/R-induced kidney injury remains unclear.

Manipulation of Cooper-Pair Tunneling via Domain Structure in a van der Waals Ferromagnetic Josephson Junction.

Ferromagnetic Josephson junctions play a key role in understanding the interplay between superconductivity and ferromagnetism in condensed matter physics. The magnetic domain structures of the ferromagnet in such junctions can significantly affect the tunneling of the superconducting Cooper pairs due to the strong interactions between Cooper pairs and local magnetic moments in the ferromagnetic tunnel barrier. However, the underlying microscopic mechanism of relevant quasiparticle tunneling processes with magnetic domain structures remains largely unexplored.

M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction.

Background: Myocardial infarction (MI) is a major cause of mortality and morbidity worldwide. The intercellular communication in post-infarction angiogenesis remains unclear.

Methods: In this study, we explored the role and mechanism of action of M2 macrophage-derived exosomes (M2-exos) in angiogenesis after MI.

Superionic fluoride gate dielectrics with low diffusion barrier for two-dimensional electronics.

Exploration of new dielectrics with a large capacitive coupling is an essential topic in modern electronics when conventional dielectrics suffer from the leakage issue near the breakdown limit. Here, to address this looming challenge, we demonstrate that rare-earth metal fluorides with extremely low ion migration barriers can generally exhibit an excellent capacitive coupling over 20 μF cm (with an equivalent oxide thickness of ~0.15 nm and a large effective dielectric constant near 30) and great compatibility with scalable device manufacturing processes.

Metal coordination nanotheranostics mediated by nucleoside metabolic inhibitors potentiate STING pathway activation for cancer metalloimmunotherapy.

Activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is an effective way to initiate an immune response against tumors, and the research on agonists targeting STING has become a new hotspot in the development of antitumor drugs. However, as a novel STING agonist, the limited bioavailability and activation routes of manganese ions (Mn) significantly hinder its antitumor effects. To address these challenges, we have designed a metal-coordinated nucleoside metabolic inhibitor (gemcitabine, Gem)-induced metal nanotheranostic (MGP) with PEGylation.

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia.

Chronic pain emerges as a major global health issue, significantly impacting individuals' health and quality of life. In this study, we designed a bilayer microneedle loaded with lidocaine nanocomposites in the inner layer and adrenaline (Adr) in the outer layer (HCP MNs) for modulated sequential release to achieve prolonged local anesthesia. The obtained HCP MNs featured an intact structure with adequate mechanical strength for efficient skin penetration.

Association between novel inflammatory markers and non-alcoholic fatty liver disease: a cross-sectional study.

Objective: This study aimed to investigate the association between novel inflammatory markers (NIMs) and non-alcoholic fatty liver disease (NAFLD).

Methods: A total of 6306 subjects were enrolled in this cross-sectional study. NIMs, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein to albumin ratio (CAR), lymphocyte to monocyte ratio (LMR), systemic immune-inflammation index (SII) and prognostic nutritional index (PNI), were calculated.

Association of blood pressure variability with target organ damage in older patients with essential hypertension.

Background: Although multiple measures of blood pressure variability (BPV) have been proposed, whether they are better than mean blood pressure in predicting target organs is unclear. We aimed to determine the relationship between short term BPV and target organ injury.

Methods: This study was a retrospective study, and 635 inpatients in the Department of Cardiology from 2015 to 2020 were selected.

Robustness of Trion State in Gated Monolayer MoSe under Pressure.

Quasiparticles consisting of correlated electron(s) and hole(s), such as excitons and trions, play important roles in the optical phenomena of van der Waals semiconductors and serve as unique platforms for studies of many-body physics. Herein, we report a gate-tunable exciton-to-trion transition in pressurized monolayer MoSe, in which the electronic band structures are modulated continuously within a diamond anvil cell. The emission energies of both the exciton and trion undergo large blueshifts over 90 meV with increasing pressure.

An anisotropic van der Waals dielectric for symmetry engineering in functionalized heterointerfaces.

Van der Waals dielectrics are fundamental materials for condensed matter physics and advanced electronic applications. Most dielectrics host isotropic structures in crystalline or amorphous forms, and only a few studies have considered the role of anisotropic crystal symmetry in dielectrics as a delicate way to tune electronic properties of channel materials. Here, we demonstrate a layered anisotropic dielectric, SiP, with non-symmorphic twofold-rotational C symmetry as a gate medium which can break the original threefold-rotational C symmetry of MoS to achieve unexpected linearly-polarized photoluminescence and anisotropic second harmonic generation at SiP/MoS interfaces.

Valley-dimensionality locking of superconductivity in cubic phosphides.

Two-dimensional superconductivity is primarily realized in atomically thin layers through extreme exfoliation, epitaxial growth, or interfacial gating. Apart from their technical challenges, these approaches lack sufficient control over the Fermiology of superconducting systems. Here, we offer a Fermiology-engineering approach, allowing us to desirably tune the coherence length of Cooper pairs and the dimensionality of superconducting states in arsenic phosphides AsP under hydrostatic pressure.

Global and national burden of atherosclerosis from 1990 to 2019: trend analysis based on the Global Burden of Disease Study 2019.

Background: Atherosclerosis-related diseases represent significant health issues among adults globally. Despite their widespread impact, comprehensive data concerning the global and national burden and trends of these diseases remain sparse. Our objective is to examine the trends in the burden of atherosclerosis among adults from 1990 to 2019 at both global and national levels.

Berry curvature dipole generation and helicity-to-spin conversion at symmetry-mismatched heterointerfaces.

The Berry curvature dipole (BCD) is a key parameter that describes the geometric nature of energy bands in solids. It defines the dipole-like distribution of Berry curvature in the band structure and plays a key role in emergent nonlinear phenomena. The theoretical rationale is that the BCD can be generated at certain symmetry-mismatched van der Waals heterointerfaces even though each material has no BCD in its band structure.

Optimal antiplatelet therapy for patients after antiplatelet therapy induced gastrointestinal bleeding: timing.

Adjusting antiplatelet strategies after antiplatelet-associated gastrointestinal bleeding (GIB) is a complex clinical challenge. To assess the risk of outcomes at different times of resumption of antiplatelet therapy in an attempt to find the optimal time to resume therapy. The study analyzed consecutive patients with antiplatelet-associated GIB from Beijing Friendship Hospital Information System between October 2019 and June 2022.

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants.

The pandemic of COVID-19 caused by SARS-CoV-2 continues to spread around the world. Mutant strains of SARS-CoV-2 are constantly emerging. At present, Omicron variants have become mainstream.

Effect of complete percutaneous revascularization on improving long-term outcomes of patients with chronic total occlusion and multi-vessel disease.

Background: Limited data are available on the comparison of clinical outcomes of complete vs. incomplete percutaneous coronary intervention (PCI) for patients with chronic total occlusion (CTO) and multi-vessel disease (MVD). The study aimed to compare their clinical outcomes.

Fabrication of PbO/PVDF/CC Composite and Employment for the Removal of Methyl Orange.

The in situ electrochemical oxidation process has received considerable attention for the removal of dye molecules and ammonium from textile dyeing and finishing wastewater. Nevertheless, the cost and durability of the catalytic anode have seriously limited industrial applications of this technique. In this work, the lab-based waste polyvinylidene fluoride membrane was employed to fabricate a novel lead dioxide/polyvinylidene fluoride/carbon cloth composite (PbO/PVDF/CC) via integrated surface coating and electrodeposition processes.