Publications by authors named "Zexing Lin"
There is growing evidence that the protein family of Gasdermins (GSDMs) play an essential role during the progression of colorectal cancer (CRC). However, it is not completely clear that how GSDMB, abundantly expressed in epithelial cells of gastrointestinal tract, regulates the tumorigenesis of CRC. A wealth of evidence linking GSDMB to the pathogenesis of cancer has come from genome-wide association studies.
View Article and Find Full Text PDFFASN regulates STING palmitoylation via malonyl-CoA in macrophages to alleviate sepsis-induced liver injury.
Biochim Biophys Acta Mol Basis Dis
October 2024
Article Synopsis
- STING is an important protein that helps regulate immune responses during sepsis and is influenced by a process called palmitoylation, which involves adding palmitic acid to proteins.
- FASN is the enzyme responsible for producing palmitic acid and is crucial for the palmitoylation of proteins, but how it interacts with STING is not fully understood until now.
- This study used STING-knockout mice to demonstrate STING's key role in liver injury caused by sepsis and found that inhibiting FASN significantly affected the STING pathway, highlighting a new link between immune regulation and metabolism.