Publications by authors named "Zexiao Fan"
Pickering emulsion has great potential as a vaccine adjuvant due to its unique advantages such as its high antigen loading efficiency, great stability, etc. Among several adjuvants on the market, aluminum adjuvant (Alum) is the most widely used at present. However, problems such as the inability to effectively induce cellular immunity and the poor effect on subunit vaccines limit the application of Alum.
View Article and Find Full Text PDFPickering emulsion stabilized by Chinese Yam polysaccharides PLGA for enhanced humoral and cellular immune responses.
Colloids Surf B Biointerfaces
October 2022
Article Synopsis
- Chinese yam polysaccharides (CYP) demonstrate significant adjuvant activity, enhancing immune responses when used in vaccine formulations, particularly in a PLGA-stabilized Pickering emulsion.
- Research shows that CYP-PPAS boosts the efficiency of antigen uptake by dendritic cells (DCs) and promotes the recruitment and maturation of DCs and macrophages in vivo.
- The use of CYP-PPAS leads to increased activation of various immune cells, fostering robust humoral and cellular responses, making it a promising candidate for vaccine delivery systems.