Publications by authors named "Zewen Chang"
Objective: To examine the causal association between 15 dietary factors and the incidence of colorectal cancer through the application of Mendelian randomization methodology.
Methods: The data associated with 15 dietary factors were derived from the IEU OPEN GWAS database, and the colorectal cancer data were sourced from the FinnGen database. The Inverse Variance Weighting method was the principal research method.
The purpose of this study was to investigate the causal association between unhealthy lifestyle style factors and the risk of colorectal cancer, with the aim of preventing the occurrence of colorectal cancer by modifying unhealthy lifestyles. A two-sample Mendelian randomization (MR) approach was employed in this study, utilizing the inverse-variance weighted method as the primary research method. This MR analysis analyzed data of 3022 colorectal cancer cases and 174,006 controls from the FinnGen database.
View Article and Find Full Text PDFColorectal cancer (CRC) is a highly prevalent and lethal malignancy worldwide. Although immunotherapy has substantially improved CRC outcomes, intolerance remains a major concern among most patients. Considering the pivotal role of the tumor microenvironment (TME) in tumor progression and treatment outcomes, profiling the TME at the transcriptomic level can provide novel insights for developing CRC treatment strategies.
View Article and Find Full Text PDFCircular RNAs (circRNAs) play crucial roles in malignancies. We aimed to delineate the functions and clinical importance of dysregulated circRNAs in colorectal cancer (CRC). We determined the circRNA expression profile from five CRC and paired adjacent normal tissues using circRNA microarray.
View Article and Find Full Text PDFGut microbiota display alternative profiles in patients with early-onset colorectal cancer.
Front Cell Infect Microbiol
November 2022
Article Synopsis
- More young people around the world are getting colorectal cancer early (EOCRC), so researchers wanted to study the gut bacteria of these patients.
- They compared the gut bacteria of 24 patients with EOCRC, 43 patients with late-onset colorectal cancer (LOCRC), and 31 healthy young volunteers.
- The study found that the gut bacteria in EOCRC patients was less diverse and different from the other groups, which might help explain why they get cancer at a younger age.
Article Synopsis
- The study aimed to create and validate a nomogram to predict anxiety and depression after surgery in colorectal cancer patients.
- A total of 602 patients were analyzed using logistic regression to identify key factors linked to postoperative mental health issues, resulting in the development of the predictive nomogram.
- Findings showed that factors like gender, income, and complications were significant predictors, and the nomogram demonstrated good accuracy in assessing anxiety and depression risk.