Tislelizumab plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy for elderly patients with inoperable locally advanced esophageal squamous cell carcinoma: a multicenter, randomized, parallel-controlled, phase II clinical trial.

Background: The standard treatment for elderly patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) is definitive chemoradiotherapy with S-1. However, the 3-year overall survival (OS) is limited to approximately 40%. Tislelizumab is the first- and second-line standard treatment for advanced ESCC with tolerable toxicity.

Unraveling the relapse-associated landscape and individualized therapy in stage I lung adenocarcinoma based on immune and mitochondrial metabolism hallmarks via multi-omics analyses.

Lung adenocarcinoma (LUAD) is characterized by significant molecular heterogeneity and high recurrence rate even among stage I patients. There is an urgent quest for reliable biomarkers to recognize early-stage patients at high risk and guide potential treatment. Considering the pivotal role of immune and mitochondrial metabolic hallmarks in tumor initiation and progression, we rigorously included four independent cohorts of stage I LUAD patients with or without relapse.

Identification of immunogenic antigens and evaluation of vaccine candidates against Clostridium perfringens.

Necrotic enteritis (NE) caused by Clostridium perfringens (C. perfringens) has resulted in significant losses for the poultry industry worldwide. Currently, there is no widely promoted vaccine for NE.

Site Effect of Electron Acceptors on Ultralong Organic Room-Temperature Phosphorescence.

Herein, we successfully observe the site effect of electron acceptors on ultralong organic room-temperature phosphorescence (UORTP) in the case of 7-benzo[]carbazole (BCz) derivatives: cyanophenyl on the nitrogen site can promote intersystem crossing (ISC) efficiency and enhance phosphorescence intensity by facilitating -π* transitions but make a slight change to the phosphorescence wavelength; cyanophenyl on the naphthalene site can cause a remarkable red shift of phosphorescence wavelength by reducing the T energy level of BCz derivatives and also enhance phosphorescence intensity by promoting ISC but weaken phosphorescence intensity by lowering the molecular symmetry. Three BCz derivatives (1-BCzPhCN, 2-BCzPhCN, and 3-BCzPhCN) with the electron acceptor cyanophenyl at different sites (nitrogen site and naphthalene site) were synthesized through a combination of the nucleophilic substitution reaction and the Suzuki coupling reaction. The phosphorescence properties of 1-BCzPhCN, 2-BCzPhCN, and 3-BCzPhCN in toluene solution, in a copolymerized MMA film, and in a PVA film were measured and analyzed.

Enhancement of protective efficacy of recombinant attenuated Salmonella typhimurium delivering H9N2 avian influenza virus hemagglutinins(HA) antigen vaccine candidate strains by C-C motif chemokine ligand 5 in chickens(chCCL5).

The H9N2 inactivated avian influenza vaccine cannot induce cellular and mucosal immune responses, while the attenuated Salmonella vector as an intracellular bacterium can induce dominant cellular and mucosal immune responses. However, it provides low protection against the virus when delivering viral antigens and needs further optimization. Chicken C-C motif chemokine ligand 5 (chCCL5) is an important CC chemokine associated with immune cell chemotaxis, migration, and viral infection.

Designing semiconductor materials and devices in the post-Moore era by tackling computational challenges with data-driven strategies.

In the post-Moore's law era, the progress of electronics relies on discovering superior semiconductor materials and optimizing device fabrication. Computational methods, augmented by emerging data-driven strategies, offer a promising alternative to the traditional trial-and-error approach. In this Perspective, we highlight data-driven computational frameworks for enhancing semiconductor discovery and device development by elaborating on their advances in exploring the materials design space, predicting semiconductor properties and optimizing device fabrication, with a concluding discussion on the challenges and opportunities in these areas.

Photo- and Oxygen- Synergistically Controlled Selective Expression of Organic .

Dynamic control of ultralong organic room-temperature phosphorescence (UORTP) is a charming target. Herein, we report a stimuli-responsive phosphorescence unit 7-indolo[2,3-]quinoline (NBCz) and its derivatives (PCBNBCz, FSONBCz, and NBCzSONBCz) that show photo- and oxygen- synergistically induced afterglow activation and afterglow color change in the PMMA film. PCBNBCz and FSONBCz feature a donor-acceptor (D-A) structure, and NBCzSONBCz features acceptor-bridged two different phosphorescence units (NBCz and NBCz).

Biomimetic Multiscale Oriented PVA/NRL Hydrogel Enabled Multistimulus Responsive and Smart Shape Memory Actuator.

Shape memory hydrogels provide a worldwide scope for functional soft materials. However, most shape memory hydrogels exhibit poor mechanical properties, leading to low actuation strength, which severely limits their applications in smart biomimetic devices. Herein, a strategy for muscle-inspired shape memory-oriented polyvinyl alcohol (PVA)-natural rubber latex (NRL) hydrogel (OPNH) with multiscale oriented structure is demonstrated.

Vaccine Candidate Delivering Infectious Bronchitis Virus S1 Protein to Induce Protection.

Infectious bronchitis (IB) is a highly infectious viral disease of chickens which causes significant economic losses in the poultry industry worldwide. An effective vaccine against IB is urgently needed to provide both biosafety and high-efficiency immune protection. In this study, the S1 protein of the infectious bronchitis virus was delivered by a recombinant attenuated vector to form the vaccine candidate χ11246(pYA4545-S1).

Fabrication of a tough, long-lasting adhesive hydrogel patch the synergy of interfacial entanglement and adhesion group densification.

Adhesive hydrogels (AHs) are considered ideal materials for flexible sensors. However, the lack of effective energy dissipation networks and sparse surface polar groups in AHs lead to poor mechanical properties and interfacial adhesion, which limit their practical application. Herein, a tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated the synergy of interfacial entanglement and adhesion group densification.

Achieving Colorful Ultralong Organic Room-Temperature Phosphorescence by Precise Modification of Nitrogen Atoms on Phosphorescence Units.

We successfully tune ultralong organic room-temperature phosphorescence (UORTP) by a simple strategy of precisely modifying nitrogen atoms on , and colorful ultralong phosphorescence can be achieved. We for the first time investigate the structure-function relationship between phosphorescence properties and molecular structures of . With BCz and BCz-1 as comparison, eight new were synthesized by introducing one or two nitrogen atoms to the naphthalene moiety.

Screening of immunogenic proteins and evaluation of vaccine candidates against Mycoplasma synoviae.

Mycoplasma synoviae (M. synoviae) is a serious avian pathogen that causes significant economic losses to chicken and turkey producers worldwide. The currently available live attenuated and inactivated vaccines provide limited protection.

Preparation of Epoxy Resin with Disulfide-Containing Curing Agent and Its Application in Self-Healing Coating.

Intrinsic self-healing polymers via dynamic covalent bonds have been attracting extensive attention because of their repeatable self-healing property. Herein, a novel self-healing epoxy resin was synthesized with disulfide-containing curing agent via the condensation of dimethyl 3,3'-dithiodipropionate (DTPA) and polyether amine (PEA). Therefore, in the structure of cured resin, flexible molecular chains and disulfide bonds were imported into the cross-linked polymer networks for triggering self-healing performance.

Physiological analysis and transcriptome profiling reveals the impact of microplastic on melon (Cucumis melo L.) seed germination and seedling growth.

The wide application of agricultural plastics leads to microplastic (MP) accumulation in the soil and inevitably result in MP pollution. Melon is an economically important horticultural crop that is widely cultivated with plastic film mulching. However, the impact of MP pollution on plant growth remains largely unclear.

How Matrixes Influence Room Temperature Ultralong Organic Phosphorescence: 4-Dimethylaminopyridine vs Carbazole Derivative.

How matrixes influence room temperature ultralong organic phosphorescence (RTUOP) in the doping systems is a fundamental question. In this study, we construct guest-matrix doping phosphorescence systems by using the derivatives (ISO2N-2, ISO2BCz-1, and ISO2BCz-2) of three phosphorescence units (N-2, BCz-1, and BCz-2) and two matrixes (ISO2Cz and DMAP) and systematically investigate their RTUOP properties. Firstly, the intrinsic phosphorescence properties of three guest molecules were studied in solution, in the pure powder state, and in PMMA film.

A model-based quantitative analysis of efficacy and associated factors of platelet rich plasma treatment for osteoarthritis.

Objective: While platelet rich plasma (PRP) has been extensively studied in treating osteoarthritis (OA), there has been an ongoing debate regarding the efficacy of PRP and the optimal subpopulation for PRP treatment remains unknown. The authors hereby aim to establish a pharmacodynamic model-based meta-analysis to quantitatively evaluate PRP efficacy, comparing with hyaluronic acid (HA) and identify relevant factors that significantly affect the efficacy of PRP treatment for OA.

Methods: The authors searched for PubMed and the Cochrane Library Central Register of Controlled Trials of PRP randomized controlled trials (RCTs) for the treatment of symptomatic or radiographic OA from the inception dates to 15 July 2022.

Metagenomic Discovery of " Parvarchaeales"-Related Lineages Sheds Light on Adaptation and Diversification from Neutral-Thermal to Acidic-Mesothermal Environments.

" Parvarchaeales" microbes, representing a DPANN archaeal group with limited metabolic potential and reliance on hosts for their growth, were initially found in acid mine drainage (AMD). Due to the lack of representatives, however, their ecological roles and adaptation to extreme habitats such as AMD as well as how they diverge across the lineage remain largely unexplored. By applying genome-resolved metagenomics, 28 Parvarchaeales-associated metagenome-assembled genomes (MAGs) representing two orders and five genera were recovered.

A Class of Organic Units Featuring Matrix-Controlled Color-Tunable Ultralong Organic Room Temperature Phosphorescence.

A novel class of organic units (N-1 and N-2) and their derivatives (PNNA-1 and PNNA-2) with excellent property of ultralong organic room temperature phosphorescence (UORTP) is reported. In this work, N-1, N-2, and their derivatives function as the guests, while organic powders (PNCz, BBP, DBT) and polymethyl methacrylate (PMMA) serve as the host matrixes. Amazingly, the color of phosphorescence can be tuned in different states or by varying the host matrixes.

Enhanced Resistance to in by Activating Host Immunity through Exogenous Aspf2-like Protein (VDAL) Treatment.

Sclerotinia stem rot caused by is one of the most destructive diseases in . Aspf2-like protein (VDAL) is a secretory protein of . which has been shown to enhance the resistance against fungal infections in several plants.