Publications by authors named "Zewei Chen"

Introduction: Systematic review and meta-analysis occupy the apex of the evidence pyramid, serving as the most comprehensive and reliable form of evidence-based assessment. Data extraction is a crucial juncture in meta-analysis, establishing the underpinnings for the outcomes and deductions drawn from systematic reviews (SRs). However, the frequency of data extraction errors in meta-analysis is quite significant.

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  • - The study focuses on melanoma treatment challenges, highlighting the need for a model that can predict prognosis and assess drug sensitivity using programmed cell death (PCD) modes.
  • - Researchers analyzed 13 PCD modes to create a Cell Death Index (CDI) based on gene signatures, which was validated with various data sources and showed distinct differences in patient outcomes.
  • - The CDI model effectively predicts melanoma prognosis and drug resistance, indicating that patients with higher CDI values have poorer postoperative outcomes.
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  • The study investigates the potential causal link between plasma metabolites and various types of cancer using a method called Mendelian randomization.
  • Researchers analyzed data from 1,400 plasma metabolites and 24 cancer types involving over 5 million individuals to identify significant associations.
  • Findings revealed 55 plasma metabolites linked to nine cancers, with implications for cancer detection and future research on how these metabolites might influence tumor growth and treatment.
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is a mangrove associate with high medicinal and ecological values. However, due to the dual-pressure of climate change and human activities, has become endangered in China. Moreover, misidentification between and its terrestrial relative poses further challenges to field protection and proper medicinal usage of .

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Sarcomatoid renal cell carcinoma typically signifies an exceptionally poor prognosis, with patients rarely surviving beyond one year. An 83-year-old male presented to our hospital with complaints of headache and left-sided limb weakness. Computed tomography (CT) scans of the head and lungs disclosed a mass within the right temporal lobe, accompanied by peritumoral edema in the right cerebral hemisphere.

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A zinc-catalyzed C(sp)-N dehydrative cross-coupling between carboxylic acids and NH-sulfoximines to afford N-aroylated sulfoximines under mild reaction conditions is described. Various NH-sulfoximines were coupled with readily available carboxylic acids to provide the corresponding N-aroylated sulfoximines in good to excellent yields.

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  • Chronic exposure to interferon-γ (IFN-γ) in cancers leads to tryptophan shortage via the IDO-kynurenine pathway, which results in abnormal peptides being produced through ribosomal frameshifting and codon reassignment.
  • In EBV-positive gastric cancer (GC), infiltrating lymphocytes secrete IFN-γ, increasing IDO1 expression and depleting tryptophan, which promotes the production of tryptophan-to-phenylalanine (W>F) substitutants.
  • The mTOR/eIF4E signaling pathway plays a crucial role in this process, as inhibiting it can reduce W>F substitutant production and improve antigen presentation,
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  • The study investigates the prevalence of Chlamydia trachomatis infection among high-risk groups in China, specifically female sex workers (FSWs) and men who have sex with men (MSM).
  • A total of 61 studies were analyzed, revealing a pooled prevalence of 19.5% among FSWs and varying rates in MSM, with 12.7% in the rectum, 6.4% in the urethra, and 1.3% in the oropharynx.
  • The analysis identified trends from 1998 to 2021, showing a decline in the prevalence of the infection among FSWs over the years, with different factors such as sample size and study region
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Gastric/gastroesophageal junction (G/GEJ) cancer represents a significant global health challenge. Radical surgery remains the cornerstone of treatment for resectable G/GEJ cancer. Supported by robust evidence from multiple clinical studies, therapeutic approaches, including adjuvant chemotherapy or chemoradiation, and perioperative chemotherapy, are generally recommended to reduce the risk of recurrence and enhance long-term survival outcomes post-surgery.

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Key Points: The severity of acute tubular necrosis was closely associated with renal survival. Crescent and arterial lesions are significantly associated with progression to ESKD and exerted superimposing effects together with acute tubular necrosis. Tubular atrophy/interstitial fibrosis and intracapillary lesions increase the risk of CKD stage 3–5.

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Atmospheric aerosol types and characteristics have regional and seasonal characteristics mainly due spatial and temporal differences in emission sources and diffuse transport conditions. We explored regional three-dimensional spatial and temporal distribution characteristics of aerosol types in Central Asia from daytime to nighttime by using long-term (2007-2021) CALIPSO lidar measurements. The three results are as follows: (1) Average aerosol optical depth (AOD) values during the 14 years were 0.

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Anti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. In a limited number of cases, the association of anti-GBM disease with other glomerulonephritis has been reported. Herein, we present the case of a 66-year-old female patient with progressive worsen kidney function and decreased urine output.

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Hazardous synthetic colorants have found widespread use in food production, and excessive consumption of these pigments can pose potential risks to human health. In this study, we propose an ultrasensitive fluorescence method for the analysis of Acid Red 18 (AR18) in food products. The method is based on the nitrogen-doped carbon dots (N-CDs) derived from tris and resorcinol through a hydrothermal way.

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Fabry disease (FD) is an uncommon, X-linked, lysosomal storage disease that causes defects in the glycosphingolipid metabolic pathway due to deficient or absent lysosomal α-galactosidase (α-Gal A) activity. This leads to the accumulation of globotriaosylceramide (GL-3) within lysosomes in a wide range of cells, including endothelial, cardiac, renal, and corneal cells, and consequently, the progressive appearance of clinical symptoms in target organs. Enzyme replacement therapy (ERT), which involves the exogenous supplementation of α-Gal A enzyme and has been successfully administered for treating FD.

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Introduction: Patient-reported outcomes (PROs) are health reports that come directly from the patients themselves and represented the experience and insights of the patient's perspective on the impact of the intervention. PROs were increasingly emphasised in acupuncture randomised controlled trials (RCTs). However, the reporting quality of PROs in acupuncture RCTs has not been investigated to date.

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Giant femoral arteriovenous fistulas are comparatively uncommon, typically treated through covered stents, coil embolization, and open surgical repair. Nevertheless, these options may not be appropriate for all patients. Herein, we describe a case of traumatic femoral arteriovenous fistulas that led to drastic dilatation of the femoral arteriovenous system and considerable heart failure symptoms due to prolonged lack of treatment.

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  • This study assessed how liver cirrhosis (LC) influences the challenges of minimally invasive liver resection (MILR), specifically for minor surgeries involving primary liver tumors in anterolateral segments.
  • Conducted from 2004 to 2021 across 60 centers, the research involved 3,675 patients, with varying degrees of cirrhosis classified as Child A and Child B.
  • Results indicated that patients with Child A cirrhosis faced higher risks of complications, such as increased blood loss and rates of open conversion, while those with Child B cirrhosis had longer hospital stays and more significant morbidity; overall, the severity of LC complicates the surgical process, highlighting the need for better difficulty
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  • Tumor size (TS) impacts intraoperative outcomes in laparoscopic major hepatectomy (L-MH), with this study aiming to clarify its effects and find optimal TS cutoffs for assessing surgical difficulty.
  • The analysis, which included 1396 patients from a larger pool of 3008 undergoing L-MH, identified two critical TS cutoffs at 50 mm and 100 mm that segmented patients into three distinct groups.
  • Results showed that larger TS correlated with increased open conversion rates, longer operation times, higher blood loss, and more intraoperative blood transfusions, while postoperative complications remained similar across the groups.
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  • This study aimed to compare outcomes of robotic limited liver resections (RLLR) and laparoscopic limited liver resections (LLLR) for tumors in the posterosuperior liver segments, noting that previous research had not thoroughly examined the differences in performance and safety between the two approaches.
  • An analysis of data from 3510 patients showed that RLLR had significant advantages over LLLR, including a lower rate of open conversions, reduced blood loss, and shorter operative times, even in patients with cirrhosis.
  • Despite the improved perioperative outcomes for RLLR, postoperative metrics like readmission, morbidity, and mortality rates were similar between both surgical techniques.
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Introduction: Randomised controlled trials (RCTs) play an important role in evidence-based medicine. However, an article with low reporting quality may mislead both experts and the general public into an erroneous decision. Data sharing can contribute to the truthfulness and transparency of trials.

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By doping Ni into m-CoSeO, the structure of the catalyst was modified to improve the Ethanol Oxidation Reaction (EOR) catalytic performance. The catalyst exhibited excellent EOR catalytic activity ( = 1.35 V) and high stability.

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Background: Data on the effect of body mass index on laparoscopic liver resections are conflicting. We performed this study to investigate the association between body mass index and postoperative outcomes after laparoscopic major hepatectomies.

Methods: This is a retrospective review of 4,348 laparoscopic major hepatectomies at 58 centers between 2005 and 2021, of which 3,383 met the study inclusion criteria.

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Background: This network meta-analysis investigated the effect of various combined regimens of sodium-glucose cotransporter-2 inhibitors (SGLT2is) and renin-angiotensin-aldosterone system inhibitors (RAASis) on the occurrence of hyperkalemia in diabetic kidney disease.

Methods: The risk of hyperkalemia was compared using the random-effects model of network meta-analysis, with results expressed as odds ratios (ORs) with 95% confidence intervals (CIs). The comparative effects of all medications and their combinations with placebo were ranked using the surface under the cumulative ranking probabilities.

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  • - The study investigates how body mass index (BMI) affects outcomes after laparoscopic left lateral sectionectomy (L-LLS), revealing that higher BMI levels (greater than 27kg/m²) lead to increased blood loss, longer operative times, and more open conversions during surgery.
  • - A large sample of 2,183 patients from 59 centers worldwide was analyzed, showing that as BMI increases, so do certain negative surgical outcomes, but patient complications also exhibited a "U" shaped relationship—higher rates were seen in both underweight and obese individuals.
  • - The findings suggest that BMI should be considered in evaluating the difficulty of L-LLS procedures and in future assessments of surgical risk and outcomes.
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