Publications by authors named "Zetai Bai"
Article Synopsis
- The study used data from CHARLS to investigate how diabetes affects stroke risk in middle-aged and older East Asians, using advanced genetic methods to assess causality.
- Data showed that stroke incidence increased with diabetes, with a notable 1.35 times higher risk compared to those with normal blood sugar levels.
- The findings suggest effective blood glucose management in prediabetics may lower stroke risk, while managing diabetes alone may not yield the same benefits.
Article Synopsis
- Neuroinflammation and mitochondrial function are vital for neuron health, and SS-31 is a peptide that helps reduce cell stress and inflammation in mitochondria.
- Researchers synthesized 19 new derivatives of SS-31, finding that two specific peptides, 5f and 5g, significantly lower inflammatory markers and boost energy production in cells.
- The study suggests that 5f and 5g have protective benefits for neurons and hold potential for treating neurodegenerative diseases like Alzheimer's linked to inflammation and mitochondrial issues.
Article Synopsis
- Researchers developed a new biosensor that can accurately detect exosomes from gastric cancer cells, which could help in noninvasive cancer diagnosis through liquid biopsies.
- The sensor uses advanced materials, specifically nanocomposites, that exhibit photothermal and colorimetric properties, allowing for multiple detection methods based on exosome concentration.
- Testing the sensor with human serum samples showed its effectiveness in distinguishing between gastric cancer patients and healthy individuals.
Alzheimer's disease (AD) is a severe neurodegenerative condition characterized by inflammation, beta-amyloid (Aβ) plaques, and neurodegeneration, which currently lack effective treatments. Chiral nanomaterials have emerged as a promising option for treating neurodegenerative disorders due to their high biocompatibility, strong sustained release ability, and specific enantiomer selectivity. The development of a stimulus-responsive chiral nanomaterial, UiO-66-NH @l-MoS QDs@PA-Ni (MSP-U), for the treatment of AD is reported.
View Article and Find Full Text PDFRedox imbalance and abnormal amyloid protein (Aβ) buildup are key factors in the etiology of Alzheimer's disease (AD). As an antioxidant, the hydrogen molecule (H) has the potential to cure AD by specifically scavenging highly harmful reactive oxygen species (ROS) such as OH. However, due to the low solubility of H (1.
View Article and Find Full Text PDFActivities of catalase (CAT) and superoxide dismutase (SOD) of ceria nanoparticles (CeO NPs) provide the possibility for their application in nervous system oxidative stress diseases including Alzheimer's disease (AD). The addition of hot electrons produced by a plasma photothermal effect can expand the photocatalytic activity of CeO to the near-infrared region (NIR), significantly improving its redox performance. Therefore, we coated both ends of gold nanorods (Au NRs) with CeO NPs, and photocatalysis and photothermal therapy in the NIR are introduced into the treatment of AD.
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