Publications by authors named "Zesong Cheng"
Article Synopsis
- Colorectal cancer (CRC) has one of the highest mortality rates among cancers, and abnormal DNA methylation is a key factor in its progression.
- Researchers identified a 3-CpG methylation signature linked to CRC prognosis, focusing on the gene FAM3D, which has not been thoroughly studied before.
- Low expression and high methylation of FAM3D were found to be independent risk factors for CRC, as it promotes cancer cell growth and reduces sensitivity to common chemotherapy drugs by activating the mTORC1 pathway.
Colorectal cancer (CRC) remains one of the most common malignancies worldwide and its mechanism is unclear. Polymeric immunoglobulin receptor (PIGR) which plays an important role in mucosal immunity is widely expressed in the mucosal epithelium and is dysregulated in different tumors. However, the role and underlying mechanisms of PIGR in CRC remain unclear.
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