Publications by authors named "Zeshan Haider"
Background: Sonographic placental elastography has recently been employed as a non-invasive tool to investigate the structural alterations associated with various conditions such as pre-eclampsia, gestational diabetes and fetal growth restriction (FGR). The study was conducted based on the hypothesis that the placental elasticity might differ with varying severity of FGR and with that of appropriate for gestational age (AGA) pregnancies.
Methods: This study involved 121 pregnant women, with 54 in the normal group and 67 in the FGR group, which was defined as the fetal weight below the 10th percentile for gestational age.
Article Synopsis
- Chili pepper cultivation in the Indian subcontinent faces challenges from viral diseases, highlighting the need for eco-friendly control methods and a better understanding of viral resistance mechanisms.
- The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) genes play a key role in providing resistance to various pathogens by activating systemic acquired resistance (SAR), but limited knowledge about these genes in chili restricts breeding for disease resistance.
- Analysis using bioinformatics identified five crucial genes in chili that are linked to biotic stress responses, with findings showing that the resistant variety (V1) has enhanced defense mechanisms against begomovirus infection compared to the susceptible variety (V2).
Premature leaf senescence negatively influences the physiology and yield of cotton plants. The conserved IDLNL sequence in the C-terminal region of AGL42 MADS-box determines its repressor potential for the down regulation of senescence-related genes. To determine the delay in premature leaf senescence, Arabidopsis AGL42 gene was overexpressed in cotton plants.
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- - COVID-19 is caused by the SARS-CoV-2 virus, and there is currently no effective vaccine, prompting researchers to explore drug-like compounds to inhibit the virus's main protease (M).
- - Using a Computer-Aided Drug Design approach and the "ZINC pharmer" tool, researchers identified around 1500 compounds, applying Lipinski’s rule for drug-likeness, and performing molecular docking to select promising candidates.
- - Ultimately, three compounds (ZINC20291569, ZINC90403206, ZINC95480156) were found to demonstrate strong binding energy and inhibition effects against SARS-CoV-2, indicating they may have significant potential for treating COVID-19.
Background: The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the pandemic has now been reported on all inhabited continents. Hitherto, no antiviral drug is available to combat this viral outbreak.
Methods: Keeping in mind the urgency of the situation, the current study was designed to devise new strategies for drug discovery and/or repositioning against SARS-CoV-2.