RMCNet: A Liver Cancer Segmentation Network Based on 3D Multi-Scale Convolution, Attention, and Residual Path.

Abdominal CT images are important clues for diagnosing liver cancer lesions. However, liver cancer presents challenges such as significant differences in tumor size, shape, and location, which can affect segmentation accuracy. To address these challenges, we propose an end-to-end 3D segmentation algorithm, RMCNet.

SOX12 Facilitates Hepatocellular Carcinoma Progression and Metastasis through Promoting Regulatory T-Cells Infiltration and Immunosuppression.

Despite the success of immunotherapy in treating hepatocellular carcinoma (HCC), HCC remains a severe threat to health. Here, a crucial transcription factor, SOX12, is revealed that induces the immunosuppression of liver tumor microenvironment. Overexpressing SOX12 in HCC syngeneic models increases intratumoral regulatory T-cell (Treg) infiltration, decreases CD8T-cell infiltration, and hastens HCC metastasis.

Context-dependent T-BOX transcription factor family: from biology to targeted therapy.

T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in growth and development but are also involved in immunity, cancer initiation, and progression. Moreover, the same T-BOX molecule exhibits different or even opposite effects in various developmental processes and tumor microenvironments.

The switch triggering the invasion process: Lipid metabolism in the metastasis of hepatocellular carcinoma.

In humans, the liver is a central metabolic organ with a complex and unique histological microenvironment. Hepatocellular carcinoma (HCC), which is a highly aggressive disease with a poor prognosis, accounts for most cases of primary liver cancer. As an emerging hallmark of cancers, metabolic reprogramming acts as a runaway mechanism that disrupts homeostasis of the affected organs, including the liver.

Pooled and global burdens and trends of five common cancers attributable to diet in 204 countries and territories from 1990 to 2019: an analysis of the Global Burden of Disease Study.

Objective: Increasing evidence has shown that dietary behaviors are closely correlated with the carcinogenesis and progression of many types of cancer. However, few studies have assessed the global diet-related burden of cancer. This study aimed to estimate the pooled burdens and trends of five types of cancers attributable to dietary behaviors.

Various interventions for cancer-related fatigue in patients with breast cancer: a systematic review and network meta-analysis.

Purpose: To investigate the effects of various intervention approaches on cancer-related fatigue (CRF) in patients with breast cancer.

Method: Computer searches were conducted on PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and Wanfang databases from their establishment to June 2023. Selection was made using inclusion and exclusion criteria, and 77 articles were included to compare the effects of 12 interventions on patients with breast cancer.

SOX on tumors, a comfort or a constraint?

The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation of SOX family members is closely associated with tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research to investigate the mechanisms and functions of the SOX family, confusion remains regarding aspects such as the role of the SOX family in tumor immune microenvironment (TIME) and contradictory impacts the SOX family exerts on tumors.

Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy.

Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap 'n' Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates epigenetic modifications, heme homeostasis, and oxidative stress. Additionally, it is involved in immune system development.

Effect of yoga on cancer-related fatigue in patients with breast cancer: A systematic review and meta-analysis.

Background: Breast cancer is a common malignant tumor in women and most patients with breast cancer experience fatigue. Numerous studies have investigated the relationship between yoga and cancer-related fatigue (CRF) in patients with breast cancer. However, these studies drew their conclusions from small sample sizes and lacked sufficient evidence to demonstrate that yoga can effectively alleviate CRF.

SRSF10 facilitates HCC growth and metastasis by suppressing CD8T cell infiltration and targeting SRSF10 enhances anti-PD-L1 therapy.

Background And Aims: RNA splicing is an essential step in regulating the gene posttranscriptional expression. Serine/arginine-rich splicing factors (SRSFs) are splicing regulators with vital roles in various tumors. Nevertheless, the expression patterns and functions of SRSFs in hepatocellular carcinoma (HCC) are not fully understood.

Multilocus Distance-Regulated Sensor Array for Recognition of Polyphenols via Machine Learning and Indicator Displacement Assay.

Developing new strategies to construct sensor arrays that can effectively distinguish multiple natural components with similar structures in mixtures is an exceptionally challenging task. Here, we propose a new multilocus distance-modulated indicator displacement assay (IDA) strategy for constructing a sensor array, incorporating machine learning optimization to identify polyphenols. An 8-element array, comprising two fluorophores and their six dynamic covalent complexes () formed by pairing two fluorophores with three distinct distance-regulated quenchers, has been constructed.

Lead-Free Textured Ceramics with Ultrahigh Piezoelectric Properties by Synergistic Design.

Lead-free ceramics with superior piezoelectric performance are highly desirable in various electromechanical applications. Unfortunately, it is still challenging to achieve significantly enhanced piezoelectricity without sacrificing the Curie temperature () in current BaTiO-based ceramics. To address this issue, a synergistic design strategy of integrating crystallographic texture, multiphase coexistence, and doping engineering is proposed here.

A simulation framework for reciprocal recurrent selection-based hybrid breeding under transparent and opaque simulators.

Hybrid breeding is an established and effective process to improve offspring performance, while it is resource-intensive and time-consuming for the recurrent process in reality. To enable breeders and researchers to evaluate the effectiveness of competing decision-making strategies, we present a modular simulation framework for reciprocal recurrent selection-based hybrid breeding. Consisting of multiple modules such as heterotic separation, genomic prediction, and genomic selection, this simulation framework allows breeders to efficiently simulate the hybrid breeding process with multiple options of simulators and decision-making strategies.

FGF19/FGFR4-mediated elevation of ETV4 facilitates hepatocellular carcinoma metastasis by upregulating PD-L1 and CCL2.

Background & Aims: Metastasis remains the major reason for the high mortality of patients with hepatocellular carcinoma (HCC). This study was designed to investigate the role of E-twenty-six-specific sequence variant 4 (ETV4) in promoting HCC metastasis and to explore a new combination therapy strategy for ETV4-mediated HCC metastasis.

Methods: PLC/PRF/5, MHCC97H, Hepa1-6, and H22 cells were used to establish orthotopic HCC models.

The pathophyiological role of aminoacyl-tRNA synthetases in digestive system diseases.

Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate transfer RNAs and are indispensable enzymes for protein biosynthesis in all the cells. Previously, ARSs were considered simply as housekeeping enzymes, however, they are now known to be involved in a variety of physiological and pathological processes, such as tumorigenesis, angiogenesis, and immune response. In this review, we summarize the role of ARSs in the digestive system, including the esophagus, stomach, small intestine, colon, as well as the auxiliary organs such as the pancreas, liver, and the gallbladder.

A look-ahead approach to maximizing present value of genetic gains in genomic selection.

Look-ahead selection is a sophisticated yet effective algorithm for genomic selection, which optimizes not only the selection of breeding parents but also mating strategy and resource allocation by anticipating the implications of crosses in a prespecified future target generation. Simulation results using maize datasets have suggested that look-ahead selection is able to significantly accelerate genetic gain in the target generation while maintaining genetic diversity. In this paper, we propose a new algorithm to address the limitations of look-ahead selection, including the difficulty in specifying a meaningful deadline in a continuous breeding process and slow growth of genetic gain in early generations.

Clinical outcomes of endoscopic treatment for gastric gastrointestinal stromal tumors: a single-center study of 240 cases in China.

Background And Aims: Endoscopic resection (ER) gradually becomes an important treatment method for gastrointestinal stromal tumors (GISTs). The aim of this study is to evaluate the efficacy and safety of ER of gastric GISTs.

Methods: This retrospective study included 240 patients with gastric GISTs who underwent ER at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2010 to December 2019.

CD93 Correlates With Immune Infiltration and Impacts Patient Immunotherapy Efficacy: A Pan-Cancer Analysis.

The clinical implementation of immune-checkpoint inhibitors (ICIs) targeting CTLA4, PD-1, and PD-L1 has revolutionized the treatment of cancer. However, the majority of patients do not derive clinical benefit. Further development is needed to optimize the approach of ICI therapy.

MIG/CXCL9 exacerbates the progression of metabolic-associated fatty liver disease by disrupting Treg/Th17 balance.

CD4CD25 regulatory T (Treg) cells and Th17 cells play important roles in the progression of metabolic-associated fatty liver disease (MAFLD). However, the contribution of monokine induced by interferon-gamma (MIG)/CXCL9 to the Treg/Th17 imbalance in MAFLD is only partially understood. In the present study, we detected increased levels of MIG/CXCL9 and a Treg/Th17 imbalance in the setting of metabolic-associated steatohepatitis (MASH).

[Investigation on reproductive characteristics of Polygonatum cyrtonema].

The study is aimed to investigate the reproductive biology characteristics of Polygonatum cyrtonema, especially including phenology, flower bud differentiation, flowering timing, floral traits, pollen vigor and stigma receptivity. The results showed that P. cyrtonema forms inflorescence before the leaves spread.

A New Type of Ecological Floating Bed Based on Ornamental Plants Experimented in an Artificially Made Eutrophic Water Body in the Laboratory for Nutrient Removal.

In this study, a new type of ecological floating bed (NT-EFB) employing ornamental plants (either Spathiphyllum floribundum, Hydrocotyle sibthorpioids, Chlorophytum comosum or Peperomia obtusifolia) was designed to purify confected eutrophic water for 39 days. The growth characteristics of the plants and the effect of water treatment were analyzed and compared. The results showed that: (1) all the four ornamental plants examined survived well in the eutrophic water and an increase of plant biomass was observed; (2) the degradation efficiency of TOC by adding plants was about 85.

Effects of temporary external voltage on the performance and community of microbial fuel cells.

This study evaluated the effects of temporary external voltage on the performance of two-chambered microbial fuel cells (MFC) that use nitrate wastewater as a substrate. Results indicate that the external voltage affected the performance of the MFC during their operation, and this effect remained even after the voltage was removed. The degradation efficiency of the chemical oxygen demand increased in the MFC under external voltages of 0.

[Main nutrients and functional ingredients in flowers of Polygonatum cyrtonema and P. filipes].

To reveal the main nutrients and functional ingredients in the flowers of Polygonatum cyrtonema and P. filipes, the content of the polysaccharides, saponins, amino acids, total phenols, mineral elements, and the DPPH free radical scavenging rates were determined. The flowers and rhizomes of P.

A novel method of combining generalized frequency response function and convolutional neural network for complex system fault diagnosis.

To solve the problem of low accuracy in traditional fault diagnosis methods, a novel method of combining generalized frequency response function(GFRF) and convolutional neural network(CNN) is proposed. In order to accurately characterize system state information, this paper proposed a variable step size least mean square (VSSLMS) adaptive algorithm to calculate the second-order GFRF spectrum values under normal and fault states; In order to improve the ability of fault feature extraction, a convolution neural network (CNN) with gradient descent learning rate and alternate convolution layer and pooling layer is designed to extract the fault features from GFRF spectrum. In the proposed method, the second-order GFRF spectrum of each state of Permanent Magnet Synchronous Motor (PMSM) is obtained by VSSLMS; Then, the two-dimension GFRF spectrum, which is regarded as the gray value of the image,will be further transformed into image.

Intrinsic apoptosis and proinflammatory cytokines regulated in human astrocytes infected with enterovirus 71.

Enterovirus 71 (EV71) has emerged as a clinically important neurotropic virus following poliovirus eradication. However, the mechanism of EV71-induced neurological manifestation remains largely unclear. In this study, we showed that human astrocytes were susceptible to EV71 and viral RNA was first detected at 12 h post-infection (p.