Antibody-free ultra-high performance liquid chromatography/tandem mass spectrometry measurement of angiotensin I and II using magnetic epitope-imprinted polymers.

The major challenges in measuring plasma renin activity (PRA) stem from the complexity of biological matrix, as well as from the instability and low circulating concentration of angiotensin. In this study, an ultra-high performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) based technique has been developed for the measurement of angiotensin using magnetically imprinted polymers for simultaneous enrichment of the precursor peptide angiotensin II (Ang II) and the upstream peptide precursor angiotensin I (Ang I). This technique involved surface graft imprinting in aqueous solutions using vinyl-modified nano-iron oxide as solid supports, the specificity determinant of Ang I and Ang II as the epitope, and methacrylic acid and N-t-butylacrylamide as functional monomers.

Recognition and neutralization of angiotensins I and II using an artificial nanogel receptor fabricated by ligand specificity determinant imprinting.

A nanogel combined with a molecularly imprinted polymer (MIP-nanogel) receptor was prepared using the specificity determinant as a template in aqueous media. The artificial receptor can serve as the selective recognition element for angiotensins I and II and a novel way to control hypertension was investigated.

Methyl parathion imprinted polymer nanoshell coated on the magnetic nanocore for selective recognition and fast adsorption and separation in soils.

Core-shell magnetic methyl parathion (MP) imprinted polymers (Fe3O4@MPIPs) were fabricated by a layer-by-layer self-assembly process. In order to take full advantage of the synergistic effect of hydrogen-binding interactions and π-π accumulation between host and guest for molecular recognition, methacrylic acid and 4-vinyl pyridine were chosen as co-functional monomers and their optimal proportion were investigated. The core-shell and crystalline structure, morphology and magnetic properties of Fe3O4@MPIPs were characterized.

Room temperature phosphorescence sensor for Hg2+ based on Mn-doped ZnS quantum dots.

Mercury pollution is one of the most serious concerns to human health and the environment. The development of highly sensitive and selective sensors to detect toxic mercury ions has been the focus of scientific research. In this study, L-cysteine-capped Mn-doped ZnS quantum dots (QDs) have been synthesized and used for the room temperature phosphorescence detection of Hg2+.