ELAV-like RNA binding protein 1 regulates osteogenesis in diabetic osteoporosis: Involvement of divalent metal transporter 1.

Diabetic osteoporosis (DOP) is a complication of diabetes mellitus (DM) and occurs due to alterations in bone metabolism under hyperglycemic condition. ELAV-like RNA binding protein 1 (ELAVL1) is abnormally up-regulated in diabetes-related diseases. Bioinformatics prediction indicates that divalent metal transporter 1 (DMT1) is a potential target of ELAVL1.

Unraveling the Molecular Mechanism of Prion H2 C-Terminus Misfolding by Metadynamics Simulations.

Conformational transition from the normal cellular form of prion protein (PrP) to the pathogenic "scrapie" form (PrP) is considered to be a key event in the occurrence of prion disease. Additionally, the H2 C-terminus is widely considered to be a vital site for PrP conformational transition, which can be used as an important region to explore the potential mechanism of PrP misfolding. Therefore, to study the misfolding mechanism of PrP, 500 ns well-tempered metadynamics simulations were performed by focusing on the H2 C-terminus of PrP.

Molecular basis for RGD-containing peptides supporting adhesion and self-renewal of human pluripotent stem cells on synthetic surface.

The ability to obtain a large number of human pluripotent stem cells (hPSCs) under chemically defined conditions plays a key role in clinical application of hPSCs. Chemically defined, economical and effective synthetic peptide displaying surfaces should be the optimal choice for clinical applications involving hPSCs. However, synthetic peptide displaying surfaces are worse than Matrigel surface in supporting cell adhesion and self-renewal.